Abstract
Tissue metabolism was studied in the corpus, antral, duodenal and jejunal mucosa and musculature in patients with decreased, normal and increased gastric acid output, with and without the presence of a ‘genuine’ ulcer. The term ‘genuine’ means that no clinically detectable reason was found for ulcer development in the antrum, duodenum and jejunum.
The tissue levels of ATP, ADP, AMP, RNA and DNA were measured and Mg2+-Na+-K+-dependent ATPase prepared and its activity measured in vitro, with and without the administration of various drugs.
It has been found that:
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1.
Energy and biochemical gradients exist between corpus vs. antral, antral vs. duodenal (jejunal) and corpus vs. duodenal (jejunal) mucosa in patients, dependent on their gastric acid secretions;
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2.
Energy and biochemical gradients exist between non-ulcerated and ulcerated mucosal tissues of the antrum, duodenum and jejunum (with ‘genuine’ ulcers);
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3.
The membrane ATPase activity is proportional to the amount of ATP—ADP transformation.
It has been concluded that:
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1.
Energy turnover is much higher in human gastric corpus mucosa than in antral or duodenal (jejunal) mucosa, and its extent depends on gastric acid secretion;
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2.
Energy turnover is 2–3 times higher in ulcerated antral, duodenal and jejunal mucosa than in non-ulcerated specimens;
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3.
The appearance of ‘genuine’ ulcers in the antral, duodenal and jejunal mucosa is a consequence of exhaustion of metabolic adaptation.
A uniform biochemical explanation can be found for the development of ‘genuine’ gastric, duodenal and jejunal ulcers and their location in patients.
Correspondence
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Mózsik, G., Bódis, B., Juricskay, I., Karádi, O., Kövesdy, C., Nagy, L. (1997). A New Uniform Biochemical Explanation for the Development and Location of ‘Genuine’ Gastric, Duodenal and Jejunal Ulcers in Patients. In: Gaginella, T.S., Mózsik, G., Rainsford, K.D. (eds) Biochemical Pharmacology as an Approach to Gastrointestinal Disorders. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5390-4_26
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DOI: https://doi.org/10.1007/978-94-011-5390-4_26
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