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Changes of Sensory Neuropeptides in Experimental Gastrointestinal Diseases

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Biochemical Pharmacology as an Approach to Gastrointestinal Disorders

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Abstract

Calcitonin gene-related peptide (CGRP) is a marker of afferent fibres in the upper gastrointestinal tract, being almost completely depleted following treatment with selective neurotoxin capsaicin. Decreased levels of gastric CGRP-like immunoreactivity (li) were observed during acetic acid-, cysteamine-, concentrated ethanol- and water immersion stress-ulcers. The ulcerogens did not affect tissue content of other peptides, suggesting that reduction in gastric CGRP-li cannot be attributed only to the tissue damage and, moreover, restoration of CGRP-li was observed in animals with ulcers in healing status. These findings, together with the observation that CGRP could be released during increased acid-back diffusion, suggest the involvement of CGRP during gastric ulcer formation.

Similar results were obtained in duodenal ulcers produced by cysteamine, dulcerozine or mepirizole. Decrease in duodenal CGRP-li and substance P (SP)-li was associated with the development of gastroduodenal ulcers. In a rat model of colitis, such as that induced by trinitrobenzenesulphonic acid (TNB), decreased levels of colonic CGRP-li were observed during both acute and late phases of colitis.

These findings show that sensory neuropeptides are involved in several experimental diseases and may play a significant role in their pathogenesis.

Correspondence

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Author information

Authors and Affiliations

  1. Menarini Research, Via Sette Santi 1, 50131, Florence, Italy

    S. Evangelista

  2. Gastroenterology Unit, Clinical Pathophysiology Department, University of Florence, Florence, Italy

    D. Renzi

Authors
  1. S. Evangelista
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  2. D. Renzi
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Editors and Affiliations

  1. School of Pharmacy, University of Wisconsin, Madison, WI, USA

    Timothy S. Gaginella

  2. First Department of Medicine, University Medical School of Pécs, Pécs, Hungary

    Gyula Mózsik

  3. Department of Biomedical Sciences, Sheffield Hallam University, Sheffield, UK

    K. D. Rainsford

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© 1997 Springer Science+Business Media Dordrecht

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Evangelista, S., Renzi, D. (1997). Changes of Sensory Neuropeptides in Experimental Gastrointestinal Diseases. In: Gaginella, T.S., Mózsik, G., Rainsford, K.D. (eds) Biochemical Pharmacology as an Approach to Gastrointestinal Disorders. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5390-4_16

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  • DOI: https://doi.org/10.1007/978-94-011-5390-4_16

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6267-1

  • Online ISBN: 978-94-011-5390-4

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