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Delayed Preconditioning and Adaptive Cardioprotection pp 135–153Cite as

The Heat Shock Response and Tissue Protection

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 207))

Abstract

The name of heat shock proteins (HSPs) comes from their initial discovery following heat shock treatment. In the early 1960s, Ferruccio Ritossa made the first observation that elevated temperature could trigger rapid and specific changes in chromosomal and metabolic activity of living organisms; new mRNA was synthesised within 2–3 minutes [1, 2]. During the 1970s several laboratories discovered that novel (heat shock) proteins were expressed in cells after brief elevation of temperature [3–5]. At about the same time it was also recognised that these changes in gene expression, induced by mild heat shock, were associated with a subsequent tolerance of cells [6] and organisms [7] to severe thermal injury. These pioneering studies in Drosophila cells [1–7] lead to discoveries of HSPs in all cells from bacteria to man [8], and of inducible and transient cellular protection in cells and organs as varied as heart, brain, kidney and retina, the subject of this chapter.

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  1. R. W. Currie
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  2. J.-C. L. Plumier
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Editors and Affiliations

  1. The Hatter Institute for Cardiovascular Studies, University College London Medical School, London, UK

    G. F. Baxter

  2. The Hatter Institute for Cardiovascular Studies, University College London Medical School, London, UK

    D. M. Yellon

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Currie, R.W., Plumier, JC.L. (1998). The Heat Shock Response and Tissue Protection. In: Baxter, G.F., Yellon, D.M. (eds) Delayed Preconditioning and Adaptive Cardioprotection. Developments in Cardiovascular Medicine, vol 207. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5312-6_7

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