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Changes in Cardiac Gene Expression After Ischaemia and Reperfusion

  • Chapter
Delayed Preconditioning and Adaptive Cardioprotection

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 207))

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Abstract

Physiological stress leads to the induction of new proteins that are important in mediating damage repair, affording protection from further insults or promoting cell injury and death. Identifying these proteins is an important first step towards understanding the molecular mechanisms underlying the stress response. As new or elevated protein synthesis can result from increased gene expression, studies of gene transcription provide a key to identifying proteins with important functions. In this chapter, the published data on genes that are transcriptionally up-regulated in cardiac tissue in response to ischaemia and reperfusion will be reviewed along with the transcription factors responsible for mediating the response and the known target genes. Ultimately, our interest is to understand the response of human myocardium to ischaemia and reperfusion, resulting from pathological conditions or surgery, and to understand the adaptive processes that may protect myocardial function. Few studies of gene transcription have, however, been conducted using human tissue, due to the limitations of working with living subjects. As a result, our understanding of the transcriptional response of myocardium to stress has been gained largely from animal and in vitro models. While these models have provided detailed biochemical and molecular data, the results must be interpreted with some caution.

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  1. L. V. Mayne
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Editors and Affiliations

  1. The Hatter Institute for Cardiovascular Studies, University College London Medical School, London, UK

    G. F. Baxter

  2. The Hatter Institute for Cardiovascular Studies, University College London Medical School, London, UK

    D. M. Yellon

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Mayne, L.V. (1998). Changes in Cardiac Gene Expression After Ischaemia and Reperfusion. In: Baxter, G.F., Yellon, D.M. (eds) Delayed Preconditioning and Adaptive Cardioprotection. Developments in Cardiovascular Medicine, vol 207. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5312-6_6

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