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Intracellular Signalling Mechanisms in Myocardial Adaptation to Ischaemia

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Delayed Preconditioning and Adaptive Cardioprotection

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 207))

Abstract

Living organisms exhibit specific responses when confronted with sudden environmental changes. The ability of cells to acclimatise to a new environment is the basis of adaptive modification. Adaptation involves a number of cellular and biochemical alterations including (i) changes in metabolic homeostasis and (ii) reprogramming of gene expression. Changes in metabolic pathways are generally short-lived and reversible; the consequences of reprogrammed gene expression are long-term and may lead to permanent alteration.

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  1. D. K. Das
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Editors and Affiliations

  1. The Hatter Institute for Cardiovascular Studies, University College London Medical School, London, UK

    G. F. Baxter

  2. The Hatter Institute for Cardiovascular Studies, University College London Medical School, London, UK

    D. M. Yellon

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Das, D.K. (1998). Intracellular Signalling Mechanisms in Myocardial Adaptation to Ischaemia. In: Baxter, G.F., Yellon, D.M. (eds) Delayed Preconditioning and Adaptive Cardioprotection. Developments in Cardiovascular Medicine, vol 207. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5312-6_5

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  • DOI: https://doi.org/10.1007/978-94-011-5312-6_5

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