Abstract
The aryl(hetaryl)piperazine derivatives form numerous group of anxiolytics of novel generation. They influence on the neuromediator processes of CNS through the binding with the serotonin and dopamine brain receptors. The analysis of buspiron (I) and of some its analogs influence on neuronal and behavioural reactions of animals allow to conclude that at least two components: serotoninomimetic and dopaminolytic are responsible for the demonstration of anxiolytic activity [1,2]. More over, analogs of buspiron: hepiron (II) and ipsapiron (III), which do not interact with dopaminergic brain systems, demonstrate more low anxiolytic activity in comparison with buspiron [2,3].
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Andronati, S.A., Voronina, T.A., Sava, V.M., Molodavkin, G.M., Makan, S.Y., Soboleva, S.G. (1998). Affinity for Both 5-HT1A- and D1-Receptors and Anxiolytic Activity of N-(Arylpiperazinylalkyl) Phthalimides. In: Coleman, A.W. (eds) Molecular Recognition and Inclusion. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5288-4_32
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DOI: https://doi.org/10.1007/978-94-011-5288-4_32
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