Abstract
Possible problems stemming from hydrostatic pressure effects in electrokinetically driven, chip-based analysis systems have been alluded to in the literature, but to date, no detailed study has appeared. This paper discusses the dependence of electroosmotic flow (EOF) on hydrostatic pressure (PH) in etched microchannels of constant cross-sectional area. In addition, video studies show that under certain EOF/PH conditions, bi-directional flow can be observed in microchannels. In a channel whose cross-sectional area varies over its length, this can lead to the establishment of circulatory flow patterns. This type of effect and the conditions needed to generate it are also described.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
A. Manz et al., Electroosmotic pumping and electrophoretic separations for miniaturized chemical analysis systems, J. Micromech. Microeng. 4 (1994) 257–65.
C.L. Rice and R. Whitehead, Electrokinetic flow in a narrow cylindrical capillary, J. Phys. Chem. 69 (1965) 4017–4024.
H. Li and R.J. Gale, Hydraulic and electroosmotic flow through silica capillaries, Langmuir 9 (1993) 1150–1155.
R. Datta and V.R. Kotamarthi, Electrokinetic dispersion in capillary electrophoresis, AIChE J. 36 (1990) 916–926.
E. Grushka, Effect of hydrostatic flow on the efficiency in capillary electrophoresis, J. Chromatog. 559 (1991) 81–93.
R.K. Shah and A.L. London, Laminar flow forced convection in ducts, Academic Press, 1978, 267–8.
X. Huang et al., Current-monitoring method for measuring the electroosmotic flow rate in capillary zone electrophoresis, Anal. Chem. 60 (1988) 1837–1838.
D.E. Raymond et al., Continuous sample pretreatment using a free-flow electrophoresis device integrated onto a silicon chip, Anal. Chem. 66 (1994) 2858–2865.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer Science+Business Media Dordrecht
About this paper
Cite this paper
Boer, G., Dodge, A., Fluri, K., van der Schoot, B.H., Verpoorte, E., de Rooij, N.F. (1998). Studies of Hydrostatic Pressure Effects in Electrokinetically Driven μTAS. In: Harrison, D.J., van den Berg, A. (eds) Micro Total Analysis Systems ’98. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5286-0_12
Download citation
DOI: https://doi.org/10.1007/978-94-011-5286-0_12
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6225-1
Online ISBN: 978-94-011-5286-0
eBook Packages: Springer Book Archive