Skip to main content

Floppy Mitral Valve/Mitral Valve Prolapse: Cardiac Arrhythmias

  • Chapter
Cardiac Arrhythmias, Pacing & Electrophysiology

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 201))

Abstract

Multiple clinical investigators contributed to our understanding of the floppy mitral valve/mitral valve prolapse (FMV/MVP), an important clinical entity in valvular heart disease1–8. FMV/MVP postural auscultatory phenomena (posturally mediated changes in timing and intensity of the systolic click-apical systolic murmur) were explained in haemodynamic terms in the 1970s as changes in timing and extent of MVP and the time of onset and duration of mitral regurgitation were related to postural changes in left ventricular volume and contractility1–8. Thus, by the late 1970s, clinical auscultatory, postural auscultatory dynamics and angiographic definition of FMV/MVP characteristics, with established pathological correlates, provided a reasonable clinical diagnostic profile of the FMV/MVP, mitral regurgitation triad. When M-mode echocardiography was introduced as the diagnostic standard for MVP, the auscultatory-phonocardiographic and angiographic diagnostic criteria and correlates that existed for FMV/ MVP, mitral regurgitation, were relegated to a minority position1–3. Patients or individuals with small, hyperdynamic left ventricles had false-positive echocardiograms and were placed into the same category as patients with the FMV/MVP. As the MVP pendulum moves away from the exaggerated prevalence figures of the past two decades, it is apparent that the FMV occupies the high ground and is the central issue in the FMV/MVP, mitral regurgitation triad (Fig. 1).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Boudoulas H, Wooley CF. Mitral Valve Prolapse and the Mitral Valve Prolapse Syndrome. Mount Kisco, NY: Futura; 1988.

    Google Scholar 

  2. Wooley CF, Sparks EH, Boudoulas H. The floppy mitral valve-mitral valve prolapse-mitral valvular regurgitation triad. ACC Curr J Rev 1994; July/August: 23–6.

    Google Scholar 

  3. Boudoulas H, Kolibash AJ, Baker P, King BD, Wooley CF. Mitral valve prolapse and the mitral valve prolapse syndrome: a diagnostic classification and pathogenesis of symptoms. Am Heart J 1989; 118: 796–818.

    Article  PubMed  CAS  Google Scholar 

  4. Davies MJ, Moore BP, Braimbridge MV. The floppy mitral valve. Study of incidence, pathology, and complications in surgical, necropsy and forensic material. Br Heart J 1978; 40: 468–81.

    Article  PubMed  CAS  Google Scholar 

  5. Barlow JB, Pocock WA, Marchand P et al. The significance of late systolic murmurs. Am Heart J 1963; 66: 443–52.

    Article  Google Scholar 

  6. Criley JM, Lewis KB, Humphries JO’N et al. Prolapse of the mitral valve: clinical and cineangiographic findings. Br Heart J 1966; 18: 488–96.

    Article  Google Scholar 

  7. Pyeritz RE. Heritable disorders of connective tissue. In: Boudoulas H, Wooley CF, editors. Mitral Valve Prolapse and the Mitral Valve Prolapse Syndrome. Mount Kisco, NY: Futura; 1988: 129–46.

    Google Scholar 

  8. Devereux RB, Kramer-Fox R. Inheritance and phenotypic features of mitral valve prolapse. In: Boudoulas H, Wooley CF, editors. Mitral Valve Prolapse and the Mitral Valve Prolapse Syndrome. Mount Kisco, NY: Futura; 1988: 109–27.

    Google Scholar 

  9. Marks AR, Choong CY, Chir MBB, Sanfilippo AJ, Ferre M, Weyman AE. Identification of high-risk and low-risk subgroups of patients with mitral valve prolapse. N Engl J Med 1989; 320: 1031–6.

    Article  PubMed  CAS  Google Scholar 

  10. Schaal SF. Mitral valve prolapse: Cardiac arrhythmias and electrophysiological correlates. In: Boudoulas H, Wooley CF, editors. Mitral Valve Prolapse and the Mitral Valve Prolapse Syndrome. Mount Kisco, NY: Futura; 1988: 567–90.

    Google Scholar 

  11. Schaal SF. Ventricular arrhythmias in patients with mitral valve prolapse. In: Greenspon AJ, Waxman HL, editors. Contemporary Management of Ventricular Arrhythmias. Philadelphia, PA: FA Davis; 1992: 307–16.

    Google Scholar 

  12. Zuppiroli A, Mori F, Favilli S, Barchielli A, Corti G, Montereggi A, Dolara A. Arrhythmias in mitral valve prolapse: relation to anterior mitral leaflet thickening, clinical variables, and color Doppler echocardiographic parameters. Am Heart J 1994; 128: 919–27.

    Article  PubMed  CAS  Google Scholar 

  13. Sniezek-Maciejewska M, Dubiel JP, Piwowarska W et al. Ventricular arrhythmias and the autonomic tone in patients with mitral valve prolapse. Clin Cardiol 1992; 15: 720–4.

    Article  PubMed  CAS  Google Scholar 

  14. Banasiak W, Pajak I, Ponikowski P et al. P-wave signal-averaged electrocardiogram in patients with idiopathic mitral valve prolapse syndrome and supraventricular arrhythmias. Int J Cardiol 1995; 50: 175–80.

    Article  PubMed  CAS  Google Scholar 

  15. Negi PC, Kaul U, Dev V, Bahl VK, Bajaj R. Arrhythmias and conduction defects in patients with mitral valve prolapse: a study based on ambulatory monitoring and electrophysiologic studies. J Assoc Phys India 1992; 40: 367–70.

    CAS  Google Scholar 

  16. Babuty D, Cosnay P, Breuillac JC et al. Ventricular arrhythmia factors in mitral valve prolapse. PACE 1994; 17: 1090–9.

    Article  PubMed  CAS  Google Scholar 

  17. Vohra J, Sathe S, Warren R, Tatoulis J, Hunt D. Malignant ventricular arrhythmias in patients with mitral valve prolapse and mild mitral regurgitation. PACE 1993; 16: 387–93.

    Article  PubMed  CAS  Google Scholar 

  18. Lemery R, Brugada P, Bella PD, Dugernier T, Dool AVD, Wellens HJJ. Nonischemic ventricular tachycardia. Clinical course and long-term follow-up in patients without clinically overt heart disease. Circulation 1989; 79: 990–9.

    Article  PubMed  CAS  Google Scholar 

  19. Boudoulas H, Schaal SF, Stang JM, Fontana ME, Kolibash AJ, Wooley CF. Mitral valve prolapse: cardiac arrest with long-term survival. Int J Cardiol 1990; 26: 37–44.

    Article  PubMed  CAS  Google Scholar 

  20. Boudoulas H, Reynolds FC, Mazzaferri E, Wooley CF. Metabolic studies in mitral valve prolapse syndrome. Circulation 1980; 61: 1200–5.

    Article  PubMed  CAS  Google Scholar 

  21. Boudoulas H, Reynolds FC, Mazzaferri E, Wooley CF. Mitral valve prolapse syndrome: the effect of adrenergic stimulation. J Am Coll Cardiol 1983; 2: 638–44.

    Article  PubMed  CAS  Google Scholar 

  22. Kligfield P, Boudoulas H, Wooley CF. Mitral valve prolapse: Sudden death. In: Boudoulas H, Wooley CF, editors. Mitral Valve Prolapse and the Mitral Valve Prolapse Syndrome. Mount Kisco, NY: Futura; 1988: 591–631.

    Google Scholar 

  23. Sniezek-Maciejewska M, Dubiel JP, Piwowarska W et al. Ventricular arrhythmias and the autonomic tone in patients with mitral valve prolapse. Clin Cardiol 1992; 15: 720–4.

    Article  PubMed  CAS  Google Scholar 

  24. Hansen DE, Craig CS, Hondeghem LM. Stretch-induced arrhythmias in the isolated canine ventricle. Evidence for the importance of mechanoelectrical feedback. Circulation 1990; 81: 1094–105.

    Article  PubMed  CAS  Google Scholar 

  25. Rosen S, Lahorra M, Cohen MV, Buttrick P. Ventricular fibrillation threshold is influenced by left ventricular stretch and mass in the absence of ischaemia. Cardiovasc Res 1991; 25: 458–62.

    Article  PubMed  CAS  Google Scholar 

  26. Calkins H, Levine JH, Kass DA. Electrophysiological effect of varied rate and extent of acute in vivo left–ventricular load increase. Cardiovasc Res 1991; 25: 637–44.

    Article  PubMed  CAS  Google Scholar 

  27. Morris CE. Mechanosensitive ion channels. J Membrane Biol 1990; 113: 93–107.

    Article  CAS  Google Scholar 

  28. Franz MR, Cima R, Wang D, Profitt D, Kurz R. Electrophysiological effects of myocardial stretch and mechanical determinants of stretch-activated arrhythmias. Circulation 1992; 86: 968–78.

    Article  PubMed  CAS  Google Scholar 

  29. Sanfilippo AJ, Harrigan P, Popovic AD, Weyman AE, Levine RA. Papillary muscle traction in mitral valve prolapse: quantitation by two-dimensional echocardiography. J Am Coll Cardiol 1992; 19: 564–71.

    Article  PubMed  CAS  Google Scholar 

  30. Lee TM, Sheng-Fang S, Huang TY, Chen MF, Liau CS, Lee YT. Excessive papillary muscle traction and dilated mitral annulus in mitral valve prolapse without mitral regurgitation. Am J Cardiol 1996; 78: 482–5.

    Article  PubMed  CAS  Google Scholar 

  31. Marron K, Yacoub MH, Polak JM et al. Innervation of human atrioventricular and arterial valves. Circulation 1996; 94: 368–75.

    Article  PubMed  CAS  Google Scholar 

  32. Oki T, Fukuda N, Kawano T et al. Histopathologic studies of innervation of normal and prolapsed human mitral valves. J Heart Valve Dis 1995; 4: 496–502.

    PubMed  CAS  Google Scholar 

  33. Farb A, Tang AL, Atkinson JB, McCarthy WF, Virmani R. Comparison of cardiac findings in patients with mitral valve prolapse who die suddenly to those who have congestive heart failure from mitral regurgitation and to those with fatal noncardiac conditions. Am J Cardiol 1992; 70: 234–9.

    Article  PubMed  CAS  Google Scholar 

  34. Dollar AL, Roberts WC. Morphologic comparison of patients with mitral valve prolapse who died suddenly with patients who died from severe valvular dysfunction or other conditions. J Am Coll Cardiol 1991; 17: 921–31.

    Article  PubMed  CAS  Google Scholar 

  35. Anwar A, Kohn SR, Dunn JF et al. Altered ß adrenergic receptor function in subjects with symptomatic mitral valve prolapse. Am J Med Sci 1991; 302: 89–97.

    Article  PubMed  CAS  Google Scholar 

  36. Davies AO, Jian C, Balasubramanyam A, Codina J, Birnbaumer L. Abnormal guanine nucleotide regulatory protein in MVP dysautonomia: evidence from reconstitution of Gs*. J Clin Endocrinol Metab 1991; 72: 867–75.

    Article  PubMed  CAS  Google Scholar 

  37. Marangoni S, Scalvini S, Mai R, Quadri A, Levi GF. Heart rate variability assessment in patients with mitral valve prolapse syndrome. Am J Noninvas Cardiol 1993; 7: 210–14.

    Google Scholar 

  38. Tieleman RG, Crijns HJGM, Wiesfeld ACP, Posma J, Hamer HPM, Lie KI. Increased dispersion of refractoriness in the absence of QT prolongation in patients with mitral valve prolapse and ventricular arrhythmias. Br Heart J 1995; 73: 37–40.

    Article  PubMed  CAS  Google Scholar 

  39. Sadaniantz A, Garber CE, Carleton RA, Levinson PD, Miklozek-McNulty C. Circulatory and catecholamine responses to mental stress test in subjects with mitral valve prolapse. Am J Noninvas Cardiol 1992; 6: 313–17.

    Google Scholar 

  40. Lichodziejewska B, Klos J, Rezler J, Grudzka K, Dluzniewska M, Budaj A, Ceremuzynski L. Clinical symptoms of mitral valve prolapse are related to hypomagnesemia and attenuated by magnesium supplementation. Am J Cardiol 1997; 79: 768–72.

    Article  PubMed  CAS  Google Scholar 

  41. Zdrojewski TR, Wyrzykowski B, Krupa-Wojciechowska B. Renin-aldosterone regulation during upright posture in young men with mitral valve prolapse syndrome. J Heart Valve Dis 1995; 4: 236–41.

    PubMed  CAS  Google Scholar 

  42. Zdrojewski TR, Purzycki Z, Rynkiewicz A, Kubasik A, Wyrzykowski B, Krupa-Wojciechowska B. QT/QS2 ratio in mitral valve prolapse syndrome, hyperthyroidism and borderline hypertension: possible indication of dysautonomia. Am J Noninvas Cardiol 1993; 7: 19–22.

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Boudoulas, H., Schaal, S.F., Wooley, C.F. (1998). Floppy Mitral Valve/Mitral Valve Prolapse: Cardiac Arrhythmias. In: Vardas, P.E. (eds) Cardiac Arrhythmias, Pacing & Electrophysiology. Developments in Cardiovascular Medicine, vol 201. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5254-9_12

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-5254-9_12

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6210-7

  • Online ISBN: 978-94-011-5254-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics