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Mutation and Evolution pp 157–169Cite as

Selection, convergence, and intragenic recombination in HLA diversity

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Part of the book series: Contemporary Issues in Genetics and Evolution ((CIGE,volume 7))

Abstract

To account for high degrees of human leukocyte antigen (HLA) diversity, a method is proposed for detecting intragenic recombination or gene conversion separately from parallel substitutions or convergent evolution. An application of the method to HLA protein sequences suggests that intragenic recombination played important roles in HLA-B and DPB1, some in HLA-A and DRB1, and least in HLA-C and DQB1 diversity. However, the extent of diversity of these molecules does not necessarily correlate with the frequency of intragenic recombination, supporting the view that (balancing) selection is a primary agent of HLA diversity and often leads to convergent evolution. Computer simulation is carried out to examine two models of balancing selection under the coupled effect with mutation, intragenic recombination, and random drift in a diploid population. It is emphasized that break points by intragenic recombination need be specified to account for HLA diversity. Implications of HLA diversity in human evolution are briefly discussed.

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Author information

Authors and Affiliations

  1. Department of Biosystems Science, The Graduate University for Advanced Studies, Hayama, Kanagawa, 240-0193, Japan

    Naoyuki Takahata & Yoko Satta

Authors
  1. Naoyuki Takahata
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  2. Yoko Satta
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Editor information

Editors and Affiliations

  1. Bowling Green State University, Bowling Green, Ohio, USA

    Ronny C. Woodruff

  2. University of Oklahoma, Norman, Oklahoma, USA

    James N. Thompson Jr.

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© 1998 Springer Science+Business Media Dordrecht

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Takahata, N., Satta, Y. (1998). Selection, convergence, and intragenic recombination in HLA diversity. In: Woodruff, R.C., Thompson, J.N. (eds) Mutation and Evolution. Contemporary Issues in Genetics and Evolution, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5210-5_14

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  • DOI: https://doi.org/10.1007/978-94-011-5210-5_14

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6193-3

  • Online ISBN: 978-94-011-5210-5

  • eBook Packages: Springer Book Archive

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