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MALDI Mass Analysis of Oligonucleotides

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Selected Topics in Mass Spectrometry in the Biomolecular Sciences

Part of the book series: NATO ASI Series ((ASIC,volume 504))

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Abstract

Whereas MALDI-MS is almost universally applicable for the analysis of proteins and glycoproteins with detection limits of some fmol and upper mass limits of several hundred kDa the MALDI analysis of RNA or DNA has found to be more difficult in terms of sensitivity and accessible mass range. Progress in MALDI analysis of this class of compounds in the last years is mainly due to the development of new matrices and preparation techniques.

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Author information

Authors and Affiliations

  1. Institute of Physical and Theoretical Physics, Dep. of Instrumental Analytical Chemistry, University of Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany

    U. Bahr & M. Karas

Authors
  1. U. Bahr
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  2. M. Karas
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Editors and Affiliations

  1. Medical School, University of Texas, Houston, Texas, USA

    Richard M. Caprioli

  2. SESMA-C.N.R., Napoli, Italy

    Antonio Malorni

  3. Dipartimento di Chimica, Arcavacata di Rende, Università della Calabria, Italy

    Giovanni Sindona

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© 1997 Springer Science+Business Media Dordrecht

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Bahr, U., Karas, M. (1997). MALDI Mass Analysis of Oligonucleotides. In: Caprioli, R.M., Malorni, A., Sindona, G. (eds) Selected Topics in Mass Spectrometry in the Biomolecular Sciences. NATO ASI Series, vol 504. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5165-8_23

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  • DOI: https://doi.org/10.1007/978-94-011-5165-8_23

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6171-1

  • Online ISBN: 978-94-011-5165-8

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