Abstract
The introduction of biosensors in an industrial environment is only possible if they present a well adapted solution to an important analytical problem. In the past few years, this has been demonstrated with enzyme sensors for glucose, lactate and glutamine measurement. These biosensors have been connected via flow-injection analysis (FIA) devices and applied to batch cultures of hybridoma cells and also perfusion systems using recombinant BHK cells for the production of IL-2. It has been shown that these biosensors allow direct feedback control of the concentrations of the main nutrients.
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© 1998 Springer Science+Business Media Dordrecht
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Renneberg, R., Barford, J.P., Tse, S.M. (1998). The Use Of Biosensors in Control of Fed-Batch Processes — Opportunities and Limitations. In: Nagai, K., Wachi, M. (eds) Animal Cell Technology: Basic & Applied Aspects. Animal Cell Technology: Basic & Applied Aspects, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5161-0_35
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DOI: https://doi.org/10.1007/978-94-011-5161-0_35
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