Abstract
The retinal pigment epithelium (RPE) has a major role in maintaining the homeostasis and visual activity of the retina. Various pharmacological agents are known to affect the pigment epithelial cells primarily1,2 or to affect the neurosensory retina and damage the RPE secondarily3–5. When the physiological functions of the pigment epithelium are altered the overlying retina is also affected, resulting in a decrease of visual function.
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Lee, K.P., Valentine, R. Pathogenesis and reversibility of retinopathy induced by 1,4-bis (4-aminophenoxy)-2-phenylbenezene (2-phenyl-APB-144) in pigmented rats. Arch Toxicol. 1991; 65: 292–303.
Heywood, R., Gopinath, C. Morphological assessment of visual dysfunction. Toxicol Pathol. 1990; 18: 204–217.
Lasansky, A., DeRobertis, E. Submicroscopic changes in visual cells of rabbit induced by iodoacetate. J Biophys Biochem Cytol. 1959; 5: 245–261.
Gregory, M.H., Rutty, D.A., Wood, R.D. Differences in the retinotoxic action of chloroquine and phenothiazine derivatives. J Pathol. 1970; 102: 139–150.
Bellhorn, R.W., Bellhorn, M., Friedman, A.H., Henkind, P. Urethane-induced retinopathy in pigmented rats. Arch Ophthalmol. 1973; 12: 65–76.
Kuwabara, T, Ishikawa, Y., Kaiser-Kupfer, M.I. Experimental model of gyrate atrophy in animals. Ophthalmology. 1981; 88: 331–334.
Ishikawa, Y., Kuwabara, T., Kaiser-Kupfer, M.I. Toxic effects of ornithine and its related compound on the retina. Adv Exp Med Biol. 1982; 153: 371–378.
Marmor, M.F. Retinal detachment from hyperosmotic intravitreal injection. Invest Ophthalmol Vis Sci. 1979; 18: 1237–1244.
Uyama, M., Itagaki, T., Takahashi, K., Yamagishi, K., Ohkuma, H. Experimental ornithineinduced retinopathy. In: Zingirian, M. (ed). Retinal Pigment Epithelium. Amsterdam: Kugler & Ghedini, 1989: 45–52.
Takeuchi, M., Itagaki, T., Takahashi, K., Uyama, M.. Retinal degeneration after intravitreal injection of ornithine: 1: Early change after administration. Acta Soc Ophthalmol Jpn. 1990; 94: 1012–1023.
Takeuchi, M., Itagaki, T., Ohkuma, H., Takahashi, K., Uyama, M. Retinal degeneration after intravitreal injection of ornithine: 2: Late change after administration. Acta Soc Ophthalmol Jpn. 1992; 96: 161–168.
Takeuchi, M., Itagaki, T., Takahashi, K., Ohkuma, H., Uyama, M. Changes in the intermediate stage of retinal degeneration after intravitreal injection of ornithine. Acta Soc Ophthalmol Jpn. 1993; 97: 17–28.
Abler, A.S., Chang, C.J., Fu, J., Tso, M.O.M. Photic injury triggers apoptosis of photoreceptor cells. ARVO abstracts. Invest Ophthalmol Vis Sci. 1994; 35: 1517.
Cook, B., Lewis, G.P. Apoptotic photoreceptor degeneration in experimental retinal detachment. Invest Ophthalmol Vis Sci. 1995; 36: 990–996.
Tso, M.O.M., Zhang, C., Abler, A.S. Apoptosis leads to photoreceptor degeneration in inherited retinal dystrophy of RCS rats. Invest Ophthalmol Vis Sci. 1994; 35: 2693–2699.
Chang, G.Q., Hao, Y., Wong, F. Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. Neuron. 1993; 11: 595–605.
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© 1998 Springer Science+Business Media Dordrecht
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Maeda, H., Ogata, N., Yi, X., Takeuchi, M., Ohkuma, H., Uyama, M. (1998). Selective damage on retinal pigment epithelium causes photoreceptor cell death by apoptosis. In: Coscas, G., Piccolino, F.C. (eds) Retinal Pigment Epithelium and Macular Diseases. Documenta Ophthalmologica Proceedings Series, vol 62. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5137-5_6
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DOI: https://doi.org/10.1007/978-94-011-5137-5_6
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