Abstract
Interferon (IFN) therapy for age-related macular degeneration is still controversial. We have already demonstrated that systemic administration of human IFN-β promotes proliferation of the retinal pigment epithelium (RPE) in experimental choroidal neovascularization (CNV) in monkey eyes1. We have now performed quantitative analysis regarding RPE proliferation in the regressive process associated with experimental CNV by IFN-β to clarify the effect of IFN-β in vivo.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Tobe, T., Takahashi, K., Ohkuma, H., Uyama, M. Inhibition of experimental choroidal neovascularization by interferon beta. Invest Ophthalmol Vis Sci. 1995; 36 (suppl): 552.
Uyama, M. Choroidal neovascularization, experimental and clinical study. Acta Soc Ophthalmol Jpn. 1991; 95: 1145–1180.
Brouty-Boye, D., Zetter, B.R. Inhibition of cell motility by interferon. Science. 1980; 208: 516–518.
Friesel, R., Komoriya, A., Maciag, T. Inhibition of endotherial cell proliferation by gamma-interferon. J Cell Biol. 1987; 104: 689–696.
Tsuruoka, N., Sugiyama, M., Tawaragi, Y. et al. Inhibition of in vitro angiogenesis by lymphotoxin and interferon-y. Biochem Biophys Res Commun. 1988; 155: 429–435.
Miller, J.W., Stinson, W.G., Fojkman, J. Regression of experimental iris neovascularization with systemic alpha-interferon. Ophthalmology. 1993; 100: 9–14.
Fung, W.E. Interferon alpha 2a for treatment of age-related macular degeneration. Am J Ophthalmol. 1991; 112: 349–350.
Engler, C.B., Sander, B., Koefoed, P., Larsen, M., Vinding, T., Lund-Anderse, H. Interferon alpha-2a treatment of patients with subretinal neovascular macular degeneration. A pilot investigation. Acta Ophthalmol. 1993; 71: 27–31.
Gilies, M.C., Sarks, J.P., Beaumont, P.E et al. Treatment of choroidal neovascularization in age-related macular degeneration with interferon alfa-2a and alfa-2b. Br J Ophthalmol. 1993; 77: 759–765.
Kirkpatrick, J.N.P., Dick, A.D., Forrester, J.V. Clinical experience with interferon alfa-2a for exudative age-related macular degeneration. Br J Ophthalmol. 1993; 77: 766–770.
Poliner, L.S., Tornambe, P.E., Michelson, P.E., Heitzmann, J.G. Interferon alpha-2a for subfoveal neovascularization in age-related macular degeneration. Ophthalmology. 1993; 100: 1417–1424.
Thomas, M.A., Ibanez, H.E. Interferon alpha-2a in the treatment of subfoveal choroidal neovascularization. Am J Ophthalmol. 1993; 115: 563–568.
Matsui, M. Senile disciform macular degeneration. Jpn J Clin Ophthalmol. 1994; 48: 163–170.
Matsui, M. Applications of interferon in ophthalmological field and its ocular complications. Acta Soc Ophthalmol Jpn. 1994; 98: 511–512.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Iwashita, K., Takahashi, K., Tobe, T., Yamada, H., Uyama, M., Sone, S. (1998). Promotion of retinal pigment epithelial cell proliferation in experimental choroidal neovascularization by human interferon-beta. In: Coscas, G., Piccolino, F.C. (eds) Retinal Pigment Epithelium and Macular Diseases. Documenta Ophthalmologica Proceedings Series, vol 62. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5137-5_14
Download citation
DOI: https://doi.org/10.1007/978-94-011-5137-5_14
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6160-5
Online ISBN: 978-94-011-5137-5
eBook Packages: Springer Book Archive