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Coupling of Electron Transfer and Protein Dynamics

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Biological Electron Transfer Chains: Genetics, Composition and Mode of Operation

Part of the book series: NATO ASI Series ((ASIC,volume 512))

Abstract

Electron transfer (ET) reaction with participation of special proteins is the key process of functioning of biological systems. Till recently the high effectiveness and specific features of ET in proteins have been described solely by allowing for a protein’s static structure but their molecular dynamics has not been taken into account. However, according to the Marcus theory [1] the dynamic properties of medium constitute one of the most important parameters that govern the effectiveness of electron transfer in condensed media. The dynamic properties of proteins differ appreciably from the analogous parameters of liquids and solids. The local structural adjustment of the active center or the conformational transition of the entire protein globule during the catalytic act is a unique property of enzymes enabling them to optimize and control the chemical process. The aim of this paper is to critically analyze the existing models of long-range ET reactions in proteins. To correct the revealed discrepancies we propose a model, taking into account the molecular dynamics of proteins with a broad distribution of the relaxation times.

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Authors and Affiliations

  1. Institute of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region, 142432, Russia

    A. I. Kotelnikov, V. R. Vogel, A. V. Pastuchov, V. L. Voskoboinikov & E. S. Medvedev

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  1. A. I. Kotelnikov
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  2. V. R. Vogel
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  3. A. V. Pastuchov
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  4. V. L. Voskoboinikov
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  5. E. S. Medvedev
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Editors and Affiliations

  1. Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands

    G. W. Canters  & E. Vijgenboom  & 

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Kotelnikov, A.I., Vogel, V.R., Pastuchov, A.V., Voskoboinikov, V.L., Medvedev, E.S. (1998). Coupling of Electron Transfer and Protein Dynamics. In: Canters, G.W., Vijgenboom, E. (eds) Biological Electron Transfer Chains: Genetics, Composition and Mode of Operation. NATO ASI Series, vol 512. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5133-7_3

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  • DOI: https://doi.org/10.1007/978-94-011-5133-7_3

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