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Role of the Fibrinolytic and the Coagulation System in the Formation and Disorders of Blood Vessels

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Book cover Multiple Risk Factors in Cardiovascular Disease

Part of the book series: Medical Science Symposia Series ((MSSS,volume 12))

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Abstract

The blood coagulation, the fibrinolytic (or plasminogen/plasmin), and matrix metalloproteinase systems constitute families of proteinases that have been extensively characterized at the structural level. Previous biochemical, genetic, and epidemiologic studies suggested that they determine the balance between the formation and dissolution of blood clots and contribute to the pathogenesis of various cardiovascular disorders such as thrombosis, atherosclerosis, and restenosis. Two recently developed technologies, gene targeting and gene transfer, that allow manipulation of the genetic balance of these proteinase systems in a controllable manner in vivo have allowed more definitive elucidation of the biological role of these systems. This review summarizes the insights that have been obtained from the gene targeting studies and discusses the use of adenovirus-mediated transfer of fibrinolytic genes to study and possibly to develop novel strategies for the treatment of restenosis and thrombosis.

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Authors
  1. Peter Carmeliet
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  2. Désiré Collen
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Editor information

Editors and Affiliations

  1. Cornell University Medical College, 1300 York Avenue, Room F-105, New York, NY, USA

    Antonio M. Gotto Jr.

  2. National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA

    C. Lenfant

  3. Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy

    Rodolfo Paoletti  & A. L. Catapano  & 

  4. Giovanni Lorenzini Medical Foundation, Houston, TX, USA

    A. S. Jackson

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© 1998 Springer Science+Business Media Dordrecht

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Carmeliet, P., Collen, D. (1998). Role of the Fibrinolytic and the Coagulation System in the Formation and Disorders of Blood Vessels. In: Gotto, A.M., Lenfant, C., Paoletti, R., Catapano, A.L., Jackson, A.S. (eds) Multiple Risk Factors in Cardiovascular Disease. Medical Science Symposia Series, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5022-4_5

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  • DOI: https://doi.org/10.1007/978-94-011-5022-4_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6108-7

  • Online ISBN: 978-94-011-5022-4

  • eBook Packages: Springer Book Archive

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