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Neutrophil-Endothelial Cells Cooperation in the Handling of Leukotrienes: Role in Coronary Inflammation

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Book cover Multiple Risk Factors in Cardiovascular Disease

Part of the book series: Medical Science Symposia Series ((MSSS,volume 12))

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Abstract

Sulphido-peptide leukotrienes (cys-LT, LTC4, D4 and E4), are products of the 5-lipoxygenase (5-LO) pathway of arachidonic acid (AA) metabolism and are intimately involved in the genesis of inflammatory responses, due to their vasopermeant properties that cause plasma extravasation and diapedesis of white cells into perivascular tissues [1]. The generation of cys-LT exhibits remarkable cellular specificity; polymorphonuclear leukocytes (PMNL) generate predominantly the unstable epoxide LTA4 which is then transformed to leukotriene B4 (LTB4) [2], whereas mast cells and eosinophils show preferential generation of cys-LT.

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Authors
  1. Carola Buccellati
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  2. Giuseppe Rossoni
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  3. Albino Bonazzi
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  4. Simona Zarini
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  5. Manlio Bolla
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  6. Jacques Maclouf
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  7. Giancarlo Folco
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  8. Angelo Sala
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Editor information

Editors and Affiliations

  1. Cornell University Medical College, 1300 York Avenue, Room F-105, New York, NY, USA

    Antonio M. Gotto Jr.

  2. National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA

    C. Lenfant

  3. Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy

    Rodolfo Paoletti  & A. L. Catapano  & 

  4. Giovanni Lorenzini Medical Foundation, Houston, TX, USA

    A. S. Jackson

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© 1998 Springer Science+Business Media Dordrecht

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Buccellati, C. et al. (1998). Neutrophil-Endothelial Cells Cooperation in the Handling of Leukotrienes: Role in Coronary Inflammation. In: Gotto, A.M., Lenfant, C., Paoletti, R., Catapano, A.L., Jackson, A.S. (eds) Multiple Risk Factors in Cardiovascular Disease. Medical Science Symposia Series, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5022-4_28

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  • DOI: https://doi.org/10.1007/978-94-011-5022-4_28

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6108-7

  • Online ISBN: 978-94-011-5022-4

  • eBook Packages: Springer Book Archive

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