Abstract
Hypertension, diabetes, and dyslipidemia have long been noted as risk factors for the development of coronary heart disease (CHD) [1]. It has also been shown that these cardiovascular risk factors may cluster in the same individual. While earlier studies have suggested this clustering is related to increased overall adiposity, more recent attention has focused in the possible role of insulin resistance.
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References
Assmann G, Schulte H. The Prospective Cardiovascular Munster (PROCAM) Study: Prevalence of hyperlipidemia in persons with hypertension and/or diabetes mellitus and the relationship to coronary heart disease. Am Heart J 1988; 116: 1713–24.
Reaven GM. 1988 Banting Lecture: Role of insulin resistance in human disease. Diabetes 1988; 37: 1595–607.
Ferrannini E, Buzzigoli G, Bonadonna R, et al. Insulin resistance in essential hypertension. N Engl J Med 1987; 317: 350–57.
Garg A, Helderman JH, Koffler M, Ayuso R, Rosenstock J, Raskin P. Relationship between lipoprotein levels and in vivo insulin action in normal young white men. Metab Clin Exp 1988; 37: 982–87.
DeFronzo RA. Lilly Lecture 1987. The triumvirate: Beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 1988; 37: 667–87.
Juhan-Vague I, Alessi MC, Vague P. Increased plasma plasminogen activator inhibitor 1 levels. A possible link between insulin resistance and atherothrombosis. Diabetologia 1991; 34: 457–62.
Reaven GM, Chen YD, Jeppesen J, Maheux P, Krauss RM. Insulin resistance in individuals with small, dense lipoprotein particles. J Clin Invest 1993; 92: 141–46.
Haffner SM, Valdez RA, Hazuda HP, Mitchell BD, Morales PA, Stern MP. Prospective analyses of the Insulin Resistance Syndrome (Syndrome X). Diabetes 1992; 41: 715–22.
Laakso M. How good a marker is insulin level for insulin resistance? Am J Epidemiol 1993; 137: 959–65.
Mykkänen L, Haffner SM, Rönnemaa T, Bergman RN, Laakso M. Low insulin sensitivity is associated with a clustering of cardiovascular risk factors. Am J Epidemiol 1997; in press.
Mykkänen L, Kuusisto J, Pyörälä K, Laakso M. Cardiovascular disease risk factors as predictors of type II (non-insulin-dependent) diabetes mellitus in elderly subjects. Diabetologia 1993; 36: 553–59.
Haffner SM, Stern MP, Hazuda HP, Mitchell BD, Patterson JK. Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of clinical diabetes? JAMA 1990a; 263: 2893–98.
McPhillips JB, Barrett-Connor E, Wingard DL. Cardiovascular disease risk factors prior to the diagnosis of impaired glucose tolerance and non-insulin dependent diabetes mellitus in a community of older adults. Am J Epidemiol 1975; 131: 443–53.
Haffner SM, Stern MP, Mitchell BD, Hazuda HP, Patterson JK. Incidence of type II diabetes in Mexican Americans predicted by fasting insulin and glucose levels, obesity, and body fat distribution. Diabetes 1990b; 39: 283–88.
Lillioja S, Mott DM, Spraul M, et al. Insulin resistance and insulin secretory dysfunction as precursors of non-insulin dependent diabetes mellitus. Prospective studies of Pima Indians. N Engl J Med 1993; 329: 1988–92.
Pyörälä K, Savolainen E, Kaukola S, Haapakoski J. Plasma insulin as coronary heart disease risk factor: Relationship to other risk factors and predictive during 9 1/2 year follow-up of the Helsinki Policeman Study population. Acta Med Scand 1985; 701 (Suppl.): 38–52.
Eschwege E, Richard JL, Thibult N, et al. Coronary heart disease mortality in relation to diabetes, blood glucose and plasma-insulin levels: The Paris Prospective Study, 10 years later. Horm Metab Res 1985; 15: 41–46.
Després JP, Lamarche B, Mauriége P, et al. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med 1996; 334: 952–57.
Welin L, Eriksson H, Larsson B, Ohlson LO, Svardsudd K, Tibblin G. Hyperinsulinemia is not a major coronary risk factor in elderly men. The study of men born in 1913. Diabetologia 1992; 35: 766–70.
Ferrara A, Barrett-Connor E, Edelstein SL. Hyperinsulinemia does not increase the risk of fatal cardiovascular disease in elderly men or women without diabetes: The Rancho Bernardo Study, 1984–1991. Am J Epidemiol 1994; 140: 857–69.
Laakso M, Sarlund H, Salonen R, et al. Asymptomatic atherosclerosis and insulin resistance. Arterioscler Throm 1991; 11: 1068–76.
Bressler P, Bailey S, Matsuda M, DeFronzo RA. Insulin resistance and coronary artery disease. Diabetologia 1996; 39: 1345–50.
Howard G, O’Leary DH, Zaccaro D, et al. Insulin sensitivity and atherosclerosis. Circulation 1996; 93: 1809–17.
Wingard DL, Von Muhlen D, Barrett-Connor E, Kritz-Silverstein D. Factor analysis of proposed components of the Insulin Resistance Syndrome. Diabetes 1996;45 (Supp1.2):137A.
Meigs JB, D’Agostino RJ, Cupples LA, Wilson PW, Nathan DM, Singer DE. Evidence that insulin resistance does not verify metabolic cardiovascular disease risk variable clustering: The Framingham Offspring Study. Diabetes 1996;45(Suppl.2): 137A.
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Haffner, S.M. (1998). Clustering of Cardiovascular Risk Factors. In: Gotto, A.M., Lenfant, C., Paoletti, R., Catapano, A.L., Jackson, A.S. (eds) Multiple Risk Factors in Cardiovascular Disease. Medical Science Symposia Series, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5022-4_27
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DOI: https://doi.org/10.1007/978-94-011-5022-4_27
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