Skip to main content
SpringerLink
Log in

Commentary The polymeric immunoglobulin receptor and the Brambell receptor: non-haematopoietic FcRs, with much to compare

  • Chapter
The Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity

Part of the book series: Immunology and Medicine Series ((IMME,volume 26))

  • 112 Accesses

Abstract

The foregoing chapters cogently summarize the biology and molecular biology of the IgA and IgG transport systems, which play crucial roles in defence against infection. Whereas IgG transmission is confined to the perinatal period and is essential to the survival of newborn animals, the continuous release of IgA into secretions provides mucosae with the first barrier to infection throughout life. The juxtaposition of these chapters is most felicitous, due to the many opportune contrasts and comparisons to be made. Further, the recent confirmation of a long-postulated role of the receptor for IgG transmission in also protecting IgG from catabolism stimulates additional interesting comparisons. These are summarized in Table 7.1.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Brambell FWR, Halliday RAM, Morris IG. Interference by human and bovine serum protein fractions with the absorption of antibodies by suckling rats and mice. Proc R Soc Lond B. 1958; 149: 1–11.

    Article  PubMed  CAS  Google Scholar 

  2. Brambell FWR. The transmission of immunity from mother to young and the catabolism of immunoglobulins. Lancet. 1966;ii: 1087–93.

    Article  CAS  Google Scholar 

  3. Brambell FWR. The Transmission of Passive Immunity from Mother to Young. Amsterdam: North Holland Publishing Co.; 1970.

    Google Scholar 

  4. Brambell FWR, Hemmings WA, Morris IG. A theoretical model of γ-globulin catabolism. Nature. 1964;203: 1352–5.

    Article  PubMed  CAS  Google Scholar 

  5. Junghans RP. Finally The Bramball receptor (FcRB): mediator of transmission of immunity and protection from catabolism for IgG. Immunol Res. 1997; 16: 29–57.

    Article  PubMed  CAS  Google Scholar 

  6. Mostov KE, Kraehenbuhl JP, Blobel G. Receptor-mediated transcellular transport of immunoglobulins: synthesis of secretory component as multiple and larger transmembrane forms. Proc Natl Acad Sci USA. 1980;77: 7257–61.

    Article  PubMed  CAS  Google Scholar 

  7. van de Winkel JGJ, Capel PJA. Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications. Immunol Today. 1993; 14: 215–21.

    Article  PubMed  Google Scholar 

  8. Morton HC, van Egmond M, van de Winkel JGJ. Structure and function of human IgA Fc receptors (FcαR). Crit Rev Immunol. 1996; 16: 423–40.

    PubMed  CAS  Google Scholar 

  9. Pfefferkorn LC, Yeaman GR. Association of IgA-Fc receptors (FcαR) with FcεRI γ 2 subunits in U937 cells. Aggregation induces the tyrosine phosphorylation of γ2. J Immunol. 1994; 153: 3228–36.

    PubMed  CAS  Google Scholar 

  10. Morton HC, van den Herik-Oudijk IE, Vossebeld P et al. Functional association between the human myeloid IgA Fc receptor (CD89) and FcR γchain. Molecular basis for CD89/FcR γchain association. J Biol Chem. 1995; 270: 29781–7.

    Article  PubMed  CAS  Google Scholar 

  11. Saito K, Suzuki K, Matsuda H, Okimura K, Ra C. Physical association of Fc receptor γhomodimer with IgA receptor. J Allergy Clin Immunol. 1995; 96: 1152–60.

    Article  PubMed  CAS  Google Scholar 

  12. Levine B, Harwick JM, Trapp BD, Crawford TO. Antibody-mediated clearance of alphavirus infection from neurons. Science. 1991; 254: 856–60.

    Article  PubMed  CAS  Google Scholar 

  13. Mazanec MB, Kaetzel CS, Lamm ME, Fletcher D. Nedrud JG. Intracellular neutralization of virus by immunoglobulin A antibodies. Proc Natl Acad Sci USA. 1992; 89: 6901–5.

    Article  PubMed  CAS  Google Scholar 

  14. Dietschold B, Kao M, Zheng YM et al. Delineation of putative mechanisms involved in antibody-mediated clearance of rabies virus from the central nervous system. Proc Natl Acad Sci USA. 1992; 89: 7252–6.

    Article  Google Scholar 

  15. Randall TD, Parkhouse RME, Corley JB. J chain synthesis and secretion of hexameric IgM is differently regulated by LPS and IL5. Proc Natl Acad Sci USA. 1992; 89: 962–6.

    Article  PubMed  CAS  Google Scholar 

  16. Matsui K, Nakanishi K, Cohen DJ et al. B cell response pathways regulated by IL5 and IL2. J Immunol. 1989; 142: 2918–23.

    PubMed  CAS  Google Scholar 

  17. Kerr MA. The structure and function of human IgA. Biochem J. 1990; 271: 285–96.

    PubMed  CAS  Google Scholar 

  18. Dive C, Heremans JF. Nature and origin of the proteins of bile. I. A comparative analysis of serum and bile proteins in man. Eur J Clin Invest. 1974; 4: 235–9.

    PubMed  CAS  Google Scholar 

  19. McFarlane AS. The behavior of I131-labeled plasma proteins in vivo. Ann NY Acad Sci. 1957; 70: 19–25.

    Article  PubMed  CAS  Google Scholar 

  20. Blumberg RS, Koss T, Story CM el al. A major histocompatibility complex class 1-related Fc receptor for lgG on rat hepatocytes. J Clin Invest. 1995; 95: 2397–402.

    Article  PubMed  CAS  Google Scholar 

  21. Fernandes FR, Nagao AT, Mayer MP, Zelante F, Carneiro-Sampaio MM. Compensatory levels of salivary IgM anti-Streptococcus mutans antibodies in IgA-deficient patients. J Invest Allergol Clin Immunol. 1995; 5: 151–5.

    CAS  Google Scholar 

  22. Piskurich JF, Blanchard MH, Youngman KR, France JA, Kaetzel CS. Molecular cloning of mouse polymeric lg receptor: Functional regions of the molecule are conserved among five mammalian species. J Immunol. 1995; 154: 1735–47.

    PubMed  CAS  Google Scholar 

  23. Chintalacharuvu KR, Tavill AS, Louis LN, Vaerman JP, Lamm ME, Kaetzel CS. Disulfide bond formation between dimeric immunoglobulin A and the polymeric immunoglobulin receptor during hepatic transcytosis. Hepatology. 1994; 19: 1620–73.

    Google Scholar 

  24. Simister NE, Mostov KE. An Fc receptor structurally related to MHC class I antigens. Nature. 1989; 337: 184–7.

    Article  PubMed  CAS  Google Scholar 

  25. Burmeister WP, Huber AH, Bjorkman PJ. Crystal structure of the complex of rat neonatal Fc receptor with Fc. Nature. 1994;372: 83.

    Google Scholar 

  26. Jefferis R, Lund J, Pound J. Molecular definition of interaction sites on human IgG for Fc receptors (huFc gamma R). Mol Immunol. 1990; 27: 1237–40.

    Article  PubMed  CAS  Google Scholar 

  27. Kim JK, Tsen MF, Ghetie V, Ward ES. Identifying amino acid residues that influence plasma clearance of murine IgG1 fragments by site-directed mutagenesis. Eur J Immunol. 1994; 24: 542–8.

    Article  PubMed  CAS  Google Scholar 

  28. Kim JK, Tsen MF, Ghetie V, Ward ES. Localization of the site of the murine IgG 1 molecule that is involved in binding to the murine intestinal Fc receptor. Eur J Immunol. 1994; 24: 2429–34.

    Article  PubMed  CAS  Google Scholar 

  29. Jones EA, Waldmann TA. The mechanism of intestinal uptake and transcellular transport of IgG in the neonatal rat. J Clin Invest. 1972; 51: 2916–27.

    Article  PubMed  CAS  Google Scholar 

  30. Raghavan M, Gastinel LN, Bjorkman PJ. The class I major histocompatibility complex related Fc receptor shows pH-dependent stability differences correlating with immunoglobulin binding and release. Biochemistry. 1993; 32: 8654–60.

    Article  PubMed  CAS  Google Scholar 

  31. Roberts DM, Guenthert M, Rodewald R. Isolation and characterization of the Fc receptor from the fetal yolk sac of rat. J Cell Biol. 1990;l 11: 1867–76.

    Article  Google Scholar 

  32. Berryman M, Rodewald R. β2-microglobulin co-distributes with the heavy chain of the intestinal IgG-Fc receptor throughout the transepithelial transport pathway of the neonatal rat. J Cell Sci. 1995; 108: 2347–60.

    PubMed  CAS  Google Scholar 

  33. Hemmings WA. Protein selection in the yolk-sac splanchnopleur of the rabbit: the total uptake estimated as loss from the uterus. Proc R Soc B. 1957; 148: 76–83.

    Article  Google Scholar 

  34. Rodewald R. Distribution of immunoglobulin G receptors in the small intestine of the young rat. J Cell Biol. 1980; 85: 18–32.

    Article  PubMed  CAS  Google Scholar 

  35. Neutra MR, Kraehenbuhl JP. Transepithelial transport and mucosal defense. I. The role of M cells. Trends Cell Biol. 1992; 2: 134–8.

    Article  PubMed  CAS  Google Scholar 

  36. Weltzin R, Kraehenbuhl JP, Neutra MR. Monoclonal IgA adheres to luminal surfaces of M cells in Peyer’s patch epithelium. J Cell Biol. 1987; 105: 234a.

    Google Scholar 

  37. Gan YJ, Chodosh J, Morgan A, Sixbey JW. Epithelial cell polarization is a determinant in the infectious outcome of immunoglobulin A-mediated entry by Epstein-Barr virus. J Virol. 1997; 71: 519–26.

    PubMed  CAS  Google Scholar 

  38. Abrahamson DR, Powers A, Rodewald R. Intestinal absorption of immune complexes by neonatal rats: a route of antigen transfer from mother to young. Science. 1979; 206: 567–9.

    Article  PubMed  CAS  Google Scholar 

  39. Peppard JV, Jackson LE, Hall JG, Robertson D. The transfer of immune complexes from the lumen of the small intestine to the bloodstream in sucking rats. Immunology. 1984; 53: 385–93.

    PubMed  CAS  Google Scholar 

  40. Junghans RP, Waldmann TA. Metabolism of Tac (IL2Rα): Physiology of cell surface shedding and renal elimination, and suppression of catabolism by antibody binding. J Exp Med. 1996; 271: 10453–60.

    CAS  Google Scholar 

  41. Junghans RP, Anderson CL. The protection receptor for IgG catabolism is the β2-microglobulin-containing intestinal transport receptor. Proc Natl Acad Sci USA. 1996; 93: 5512–6.

    Article  PubMed  CAS  Google Scholar 

  42. Rodewald R. Selective antibody transport in the proximal small intestine of the young rat. J Cell Biol. 1970; 45: 635–40.

    Article  PubMed  CAS  Google Scholar 

  43. Rodewald R. Intestinal transport of antibodies in the newborn rat. J Cell Biol. 1973; 58: 189–211.

    Article  PubMed  CAS  Google Scholar 

  44. Ghetie V, Hubbard JG, Kim JK, Ysen MF, Lee Y, Ward ES. Abnormally short serum half-lives of IgG in β 2-microglobulin-deficient mice. Eur J Immunol. 1996; 26: 690–6.

    Article  PubMed  CAS  Google Scholar 

  45. Sedmak DD, Rahill BM, Osborne JM et al. In vitro and in vivo expression of the IgG protection receptor, FcRp, by vascular endothelial cells. J Immunol. 1998;in press.

    Google Scholar 

  46. Takahashi I, Nakane PK, Brown WR. Ultrastructural events in the translocation of polymeric IgA by rat hepatocytes. J Immunol. 1982; 128: 1181–7.

    PubMed  CAS  Google Scholar 

  47. Geuze HJ, Slot JW, Strous GJ et al. Intracellular receptor sorting during endocytosis: comparative immunoelectron microscopy of multiple receptors in rat liver. Cell. 1984; 37: 195–204.

    Article  PubMed  CAS  Google Scholar 

  48. Aroeti B, Kosen PA, Kuntz ID, Cohen PE, Mostov KE. Mutational and secondary structural analysis of the basolateral sorting signal of the polymeric immunoglobulin receptor. J Cell Biol. 1993; 123: 1149–60.

    Article  PubMed  CAS  Google Scholar 

  49. Mostov KE. Transepithelial transport of immunoglobulins. Ann Rev Immunol. 1994; 12: 63–84.

    Article  CAS  Google Scholar 

  50. Song W, Bomsel M, Casanova J, Vaerman JP, Mostov KE. Stimulation of transcytosis of the polymeric immunoglobulin receptor by dimeric IgA. Proc Natl Acad Sci USA. 1994; 91: 163–6.

    Article  PubMed  CAS  Google Scholar 

  51. Ahouse JJ, Hagerman CL, Mittal P et al. Mouse MHC class I-like Fc receptor encoded outside the MHC. J Immunol. 1993; 151: 6076–88.

    PubMed  CAS  Google Scholar 

  52. Kandil E, Noguchi M, Ishibashi T, Kasahara M. Structural and phylogenetic analysis of the MHC class I-like Fc receptor gene. J Immunol. 1995; 154: 5907–18.

    PubMed  CAS  Google Scholar 

  53. Waldmann TA, Strober W. Metabolism of immunoglobulins. Progr Allergy. 1969; 13: 1–110.

    CAS  Google Scholar 

  54. Mariani G, Strober W. Immunoglobulin metabolism. In: Metzger H, ed., Fc Receptors and the Action of Antibodies. American Society for Microbiology. 1990: 94–177.

    Google Scholar 

Download references

Authors
  1. R. P. Junghans
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Utrecht University, Utrecht, The Netherlands

    Jan G. J. van de Winkel

  2. Austin Research Institute, Melbourne, Australia

    P. Mark Hogarth

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Junghans, R.P. (1998). Commentary The polymeric immunoglobulin receptor and the Brambell receptor: non-haematopoietic FcRs, with much to compare. In: van de Winkel, J.G.J., Hogarth, P.M. (eds) The Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity. Immunology and Medicine Series, vol 26. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5018-7_7

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-5018-7_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6106-3

  • Online ISBN: 978-94-011-5018-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation