Abstract
Soluble FcγR (sFcγR) were discovered in supernatants of cells of the immune system during the 1970s, and called immunoglobulin G-binding factors. Twenty years later, although the structure and mechanisms of generation of sFcγR have been largely clarified [see References 1–5 for reviews], questions remain regarding their biological role. In this chapter, we will review available evidence showing that these molecules can regulate immune reactions in vitro. The question of their in vivo role will be addressed on the basis of studies performed in various pathological situations and with transgenic animals.
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Sautès, C., Galon, J., Bouchard, C., Astier, A., Teillaud, JL., Fridman, W.H. (1998). Soluble FcγR, a biological perspective. In: van de Winkel, J.G.J., Hogarth, P.M. (eds) The Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity. Immunology and Medicine Series, vol 26. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5018-7_24
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DOI: https://doi.org/10.1007/978-94-011-5018-7_24
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