Abstract
While acknowledging the importance of receptors for immunoglobulin constant regions (FcR) in regulation of the development and function of the immune system, most immunologists, and more broadly most biologists, are somewhat intimidated by this subdiscipline. This is the result of a number of factors, including FcR isoform multiplicity, general low affinity, ubiquity and frequent expression of more than one FcR isoform by individual cells. All of these factors conspire to make FcR function appear extremely complex. The reviews in this section provide a refreshing summation of our current knowledge of immunoregulatory function of FcR, and do much to demystify the discipline. Provided in the following paragraphs is an effort to integrate some of the concepts presented in the individual reviews and provide some additional information to make the treatise more seamless.
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Cambier, J.C. (1998). Commentary on FcR regulation of development and function of the immune system. In: van de Winkel, J.G.J., Hogarth, P.M. (eds) The Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity. Immunology and Medicine Series, vol 26. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5018-7_19
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DOI: https://doi.org/10.1007/978-94-011-5018-7_19
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