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The Effect of a Single-Dose Intravenous Vinpocetine on Chronic Stroke Patients. A PET Study

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Positron Emission Tomography: A Critical Assessment of Recent Trends

Part of the book series: NATO ASI Series ((ASHT,volume 51))

Abstract

With the purpose of evaluating the effect of vinpocetine (Cavinton®), given in a single-dose infusion, on the cerebral metabolism and perfusion of chronic stroke patients, we measured in 12 patients with focal cerebrovascular lesions the regional and global cerebral metabolic rates of glucose with positron emission tomography (PET) before and after a single dose intravenous vinpocetine treatment. The global and regional glucose metabolic rates showed no significant changes before and after Vinpocetine treatment, however, the kinetic constants (k1, k2), related to the facilitated transport of glucose through the blood-brain-barrier in both directions, significantly increased in the whole brain. This increase could be observed in the non-affected hemisphere and in the affected hemisphere outside the infarcted area.

The findings indicate that a single-dose vinpocetine treatment significantly improves the transport of glucose through the blood-brain-barrier in both directions (uptake and release of glucose) in the non-affected hemisphere and in the peri-infarct region of the affected hemisphere.

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Author information

Authors and Affiliations

  1. Department of Neuroscience, Karolinska Institute, S-171 77, Stockholm, Sweden

    Balázs Gulyás

  2. Department of Neurology, Debrecen University Medical School, H-4012, Debrecen, Hungary

    László Csiba & Levente Kerényi

  3. Central Laboratory for Nuclear Medicine, Debrecen University Medical School, H-4012, Debrecen, Hungary

    László Galuska

  4. PET Centre, Debrecen University Medical School, H-4012, Debrecen, Hungary

    Lajos Trón

Authors
  1. Balázs Gulyás
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  2. László Csiba
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  3. Levente Kerényi
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  4. László Galuska
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  5. Lajos Trón
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Editor information

Editors and Affiliations

  1. Department of Neuroscience, Karolinska Institute, Stockholm, Sweden

    Balázs Gulyás

  2. Hungarian PET Foundation, Debrecen, Hungary

    Balázs Gulyás

  3. Institute for Medicine, Forschungszentrum Jülich GmbH, Jülich, Germany

    Hans W. Müller-Gärtner

  4. Department of Nuclear Medicine, Heinrich-Heine-University of Düsseldorf, Düsseldorf, Germany

    Hans W. Müller-Gärtner

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© 1998 Springer Science+Business Media Dordrecht

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Gulyás, B., Csiba, L., Kerényi, L., Galuska, L., Trón, L. (1998). The Effect of a Single-Dose Intravenous Vinpocetine on Chronic Stroke Patients. A PET Study. In: Gulyás, B., Müller-Gärtner, H.W. (eds) Positron Emission Tomography: A Critical Assessment of Recent Trends. NATO ASI Series, vol 51. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4996-9_24

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  • DOI: https://doi.org/10.1007/978-94-011-4996-9_24

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6097-4

  • Online ISBN: 978-94-011-4996-9

  • eBook Packages: Springer Book Archive

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