Abstract
The parent compound imidazole (1) was first synthesized in 1858 by Debus but imidazole derivatives were known before this, e.g. lophine (2,4,5-triphenylimidazole) (2) was synthesized in 1845 by Laurent.
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References
Alworth, W.L., Lu, S-H. and Winkler, M.F. (1971) Biochemistry, 10, 1421–1424.
Bryan, J.K. (1990) Advances in the biochemistry of amino acid biosynthesis, in The Biochemistry of Plants, Vol. 16 (eds B.J. Miflin and P.J. Lea), Academic Press, San Diego, pp. 161–195.
Renz, P. (1970) Riboflavin as precursor in the biosynthesis of the 5,6-dimethylbenzimidazole moiety of vitamin B12. FEBS Letters, 6, 187–189.
Wider Reading
Breslow, R. (1991) How do imidazole groups catalyze the cleavage of RNA in enzyme models and enzymes? Evidence from ‘negative catalysis’. Accounts Chem. Res., 24, 317–320.
Dickerson, R.E. and Geis, I. (1983) Haemoglobin, Benjamin/Cummings, Menlo Park, Calif.
Findlay, D., Herries, D.G., Mathias, A.P., Rabin, B.R. and Ross, C.A. (1961) The active site and mechanism of pancreatic ribonuclease. Nature, 190, 781.
Page, M.I. (ed) (1987) Enzyme Mechanisms, The Royal Society of Chemistry,London.
Sehgal, P.B. and Tamm, I. (1980) Benzimidazoles and their nucleosides. Antibiotics and Chemotherapy, 27, 93–138.
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© 1998 Springer Science+Business Media Dordrecht
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Brown, E.G. (1998). Imidazoles and benzimidazoles. In: Ring Nitrogen and Key Biomolecules. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4906-8_2
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DOI: https://doi.org/10.1007/978-94-011-4906-8_2
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