Abstract
Fatigue can be defined as “that state following a period of mental or bodily activity, characterized by a lessened capacity for work and reduced efficiency of accomplishment, usually accompanied by a feeling of weariness, sleepiness or irritability”1.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Stedman’s Medical Dictionary. Edn. 25. Baltimore: Williams and Wilkins; 1990.
Witt-Sullivan H, Heathcote J, Cauch K, et al. The demography of primary biliary cirrhosis in Ontario, Canada. Hepatology 1990;12:98–105.
Huet P-M, Deslauriers J, Faucher C, Charbonneau J. Fatigue, mental health and depression in patients with primary biliary cirrhosis (PBC). Hepatology 1996;24:A161.
Huet P-M, Deslauriers J. Impact of fatigue on quality of life of patients with primary biliary cirrhosis. Gastroenterology 1996;110:Al215.
Cauch-Dudek K, Abbey S, Stewart DE, Heathcote E.J. Fatigue and quality of life in primary biliary cirrhosis. Hepatology 1995:22:A6.
Wessely S, Powell R. Fatigue syndromes: A comparison of chronic `postural’ fatigue with neuromuscular and affective disorders. J Neurol Neurosurg Psychiatry 1989;42:940–8.
Blakely A, Howard R, Sosich R, Murdoch J, Menkes D, Spears G. Psychological symptoms, personality and ways of coping in chronic fatigue syndrome. Psychol Med 1991;21:347–62.
Jalan R, Gibson H, Lombard MG. Patients with PBC have central but no peripheral fatigue. Hepatology 1996;24:A162.
Demitrack MA, Dale JK, Straus SE, et al. Evidence for impaired activation of the hypothalamic-pituitary-adrenal axis in patients with chronic fatigue syndrome. J Clin Endocrinol Metab 1991;73:1224–34.
Griep E, Boersman J, de Kloet E. Altered reactivity of the hypothalamic-pituitary-adrenal axis in the primary fibromyalgia syndrome. J Rheumatol 1993;20:469–74.
Joseph-Vanderpool JR, Rosenthal NE, Chrousos GP, et al. Abnormal pituitary-adrenal responses to corticotropin-releasing hormone in patients with seasonal affective disorder: Clinical and pathophysiological implications. J Clin Endocrinol Metab 1991;72:1382–7.
Sutton RE, Koob GF, Le Moal M, Rivier J, Vale W. Corticotropin releasing factor produces behavioural activation in rats. Nature 1982;297:331–3.
Koob GF, Bloom FE. Corticotropin-releasing factor and behaviour. Fed Proc 1985;44:259–63.
Bakheit AMO, Behan PO, Dinan TG, Gray CE, O’Keane V. Possible upregulation of hypothalamic 5-hydroxytryptamine receptors in patients with postural fatigue syndrome. Br Med J 1992;304:1010–12.
Goldenberg D, Mayskiy M, Mossey C, Ruthazer R, Schmid C. A randomized double-blind crossover trial of fluoxetine and amitriptylline in the treatment of fibromyalgia. Arthritis Rheum 1996;39:1852–9.
Kent S, Bluthe R-M, Kelly K, Dantzer R. Sickness behaviour as a new target for drug development. Trends Pharmacol Sci 1992;3:24–8.
Tsagarakis S, Gilles G, Rees L, Besser M, Grossman A. Interleukin-1 directly stimulates the release of corticotropin releasing factor from rat hypothalamus. Neuroendocrinology 1989;49:98–101.
Tilg H, Wilmer A, Vogel W, et al. Serum levels of cytokines in chronic liver diseases. Gastorenterology 1991;103:264–74.
Buchwald D, Wener MH, Pearlman T, Kith P. Markers of inflammation and immune activation in chronic fatigue and chronic fatigue syndrome. J Rheum 1991;24:372–6.
Swain MG, Appleyard CB, Wallace JL, Marie M. TNF-a facilitates inflammation-induced glucocorticoid secretion in rats with biliary obstruction. J Hepatol 1997;26:361–8.
Cameron GP, Oakley CL. Ligation of the common bile duct. J Pathol Bacteriol 1932;35:769–98.
Swain MG, Patchev V, Vergalla J, Chrousos GP, Jones EA. Suppression of hypothalamicpituitary-adrenal axis responsiveness to stress in a rat model of acute cholestasis. J Clin Invest 1993;91:1903–8.
Sternberg EM, Glowa JR, Smith MA, et al. Corticotropin-releasing hormone related behavioural and neuroendocrine responses to stress in Lewis and Fischer rats. Brain Res 1992;570:54–60.
Swain MG, Maric M. Defective corticotropin-releasing hormone mediated neuroendocrine and behavioural responses in cholestatic rats: Implications for cholestatic liver disease-related sickness behaviours. Hepatology 1995;22:1560–4.
Bonaz B, Tache Y. Water avoidance stress-induced c-fos expression in the rat brain and stimulation of fecal output: role of corticotropin-releasing factor. Brain Res 1994;641:21–8.
Weiss JM, Simson PG, Hoffman LJ, Abrose MJ, Cooper S, Webster A. Infusion of adrenergic receptor agonists and antagonists into the locus coeruleus and ventricular system of the brain effects on swim-motivated and spontaneous motor activity. Neuropharmacology 1986;25:367–84.
Swain MG, Marie M. Improvement in cholestasis-associated fatigue with a serotonin receptor agonist using a novel rat model of fatigue assessment. Hepatology 1997;25:291–4.
Kent S, Bluthe R-M, Dantzer R, et al. Different receptor mechanisms mediate the pyrogenic and behavioural effects of interleukin I. Proc Natl Acad Sci USA 1992;89:9117–20.
Rothwell NJ, Hopkins SJ. Cytokines and the nervous system Il: Actions and mechanisms of action. TINS 1995;18:130–6.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Swain, M.G. (1998). Fatigue in the primary biliary cirrhosis patient. In: Lindor, K.D., Heathcote, E.J., Poupon, R. (eds) Primary Biliary Cirrhosis. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4884-9_12
Download citation
DOI: https://doi.org/10.1007/978-94-011-4884-9_12
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6047-9
Online ISBN: 978-94-011-4884-9
eBook Packages: Springer Book Archive