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Leukotriene receptors

  • Chapter
Leukotrienes

Abstract

Drugs which selectively inhibit the formation or action of leukotrienes (LT) have been introduced as a new therapy in asthma. Despite the ongoing delineation of the molecular biology of the enzymes in the LT pathways, corresponding information about the receptors for LTs is sparse. Knowledge of LT receptors is mainly derived from studies of functional responses. The drugs which have been developed as antagonists of tissue receptors for cysteinyl-leukotrienes (cys-LTs) were discovered by classical strategies such as screening of new chemical entities in functional or ligand-binding assays. This chapter will review our current understanding of LT receptors.

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  1. S.-E. Dahlén
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Editors and Affiliations

  1. Merck Frosst Canada, Inc., Pointe-Claire-Dorval, Quebec, Canada

    Ian Rodger

  2. The William Harvey Research Institute, Saint Bartholomew’s Hospital Medical College, London, UK

    Jack Botting

  3. Asthma and Allergy Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

    Sven-Erik Dahlén

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Dahlén, SE. (1998). Leukotriene receptors. In: Rodger, I., Botting, J., Dahlén, SE. (eds) Leukotrienes. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4880-1_2

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  • DOI: https://doi.org/10.1007/978-94-011-4880-1_2

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