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Safety and Efficacy of Non-Prescription (OTC) Analgesics and NSAIDs pp 77–92Cite as

Therapeutic Considerations from Pharmacokinetics and Metabolism: Ibuprofen and Paracetamol

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Abstract

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID). It exists as two enantiomers (R and S ibuprofen) but only the S form is considered to have the many activities of this class of drug, effects such as analgesic, anti-inflammatory, anti-pyretic and anti-platelet actions. These pharmacological properties have been related to inhibition of prostaglandin H synthase although there is still doubt that all the pharmacological activities of this or other NSAIDs are the result only of inhibition of the synthesis of prostanoids.

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Author information

Authors and Affiliations

  1. School of Physiology and Pharmacology, School of Paediatrics, University of NSW, Sydney, 2052, Australia

    G. G. Graham & M. K. Milligan

  2. Department of Clinical Pharmacology and Toxicology, St Vincent’s Hospital, Darlinghurst, NSW, Australia

    R. O. Day, K. M. Williams & J. B. Ziegler

Authors
  1. G. G. Graham
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  2. M. K. Milligan
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  3. R. O. Day
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  4. K. M. Williams
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  5. J. B. Ziegler
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Editor information

Editors and Affiliations

  1. Division of Biomedical Sciences, School of Science and Mathematics, Sheffield Hallam University, Sheffield, UK

    K. D. Rainsford

  2. M/P Biomedical Consultants, LLC, Mill Valley, CA, USA

    M. C. Powanda

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© 1998 Springer Science+Business Media New York

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Graham, G.G., Milligan, M.K., Day, R.O., Williams, K.M., Ziegler, J.B. (1998). Therapeutic Considerations from Pharmacokinetics and Metabolism: Ibuprofen and Paracetamol. In: Rainsford, K.D., Powanda, M.C. (eds) Safety and Efficacy of Non-Prescription (OTC) Analgesics and NSAIDs. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4878-8_6

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  • DOI: https://doi.org/10.1007/978-94-011-4878-8_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6044-8

  • Online ISBN: 978-94-011-4878-8

  • eBook Packages: Springer Book Archive

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