Abstract
There is ever increasing pressure in all pharmaceutical lead discovery laboratories and programs to identify novel bioactive chemical entities more quickly and efficiently. In order to accomplish this, the process of selecting which screening leads to pursue or advance has taken center stage as the most critical task in the discovery process. In programs emphasizing natural products as a source of such lead compounds, this task is complicated by the need to differentiate activity due to: a) commonly recurring classes of “nuisance compounds”, so-called because they provide a non-specific response in a large number of bioassays; b) known secondary metabolites which may or may not occur widely, but which provide a specific response in the assay in question; and c) novel chemical entities which are specifically active in the target assay.
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Cardellina, J.H. et al. (1999). Evolving Strategies for the Selection, Dereplication and Prioritization of Antitumor and HIV-Inhibitory Natural Products Extracts. In: Bohlin, L., Bruhn, J.G. (eds) Bioassay Methods in Natural Product Research and Drug Development. Proceedings of the Phytochemical Society of Europe, vol 43. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4810-8_3
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DOI: https://doi.org/10.1007/978-94-011-4810-8_3
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