Abstract
In this paper, we develop a simple four parameter population balance model of in vivo neutrophil formation following bone marrow rescue therapy. The model is used to predict the number and type of neutrophil progenitors required to abrogate the period of severe neutropenia that normally follows a bone marrow transplant. The estimated total number of 5 billion neutrophil progenitors is consistent with the value extrapolated from a human trial. The model provides a basis for designing ex vivo expansion protocols.
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Abbreviations
- HDT:
-
high dose theraphy
- BMT:
-
bone marrow transplantation
- G-CSF:
-
Granulocyte-Colony Stimulating Factor
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© 1998 Springer Science+Business Media Dordrecht
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Nielsen, L.K., Bender, J.G., Miller, W.M., Papoutsakis, E.T. (1998). Population balance model of in vivo neutrophil formation following bone marrow rescue therapy. In: Betenbaugh, M.J., Chalmers, J.J., Arathoon, R., Chaplen, F.W.R., Mastrangelo, A.J. (eds) Cell Culture Engineering VI. Current Applications of Cell Culture Engineering, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4786-6_17
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DOI: https://doi.org/10.1007/978-94-011-4786-6_17
Publisher Name: Springer, Dordrecht
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