Abstract
Background. Relevant advantages and disadvantages of crossover/self-controlled and parallel-group studies are discussed.
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References
Moser LE. Statistical concepts fundamental to investigators. N Engl J Med 1985; 312: 890–897.
Sitthi-Amorn C, Poshyachinda V. Bias. Lancet 1993; 342(II): 286–288.
Griso JA. Making comparisons. Lancet 1993; 324(II): 157–160.
Cleophas TJ, Bailar JC. Statistical concepts fundamental to investigations [letter]. N Engl J Med 1985; 313: 1026.
Harrison DG. Clinical testing of beta-adrenergic blockade in angina pectoris, in Morselli P.O., et al. (ed.): Laboratoires d’Etudes et de Recherches Synthelabo. Vol 1, New York, Raven Press 1983; 243–250.
Brown BW. The crossover experiment for clinical trials. Biometrics 1980; 36: 69–79.
Cleophas TJ. Testing Crossover studies for carryover effects. Angiology 1989; 40: 287–293.
Van Lier HJ, Cleophas TJ. The crossover design in cardiovascular research, Abstract Book, Annual Meeting. International College of Angiology, Montreux, Switzerland, ed. by the International College of Angiology, Roslyn. N.Y., 1987; p 41.
Willan AR, Pater JL. Carryover and the two-period clinical trial. Biometrics 1986; 42: 593–599.
Hills M, Armitage P. The two-period crossover trial. Br J Clin Pharmacol 1979; 8: 7–20.
Barker M, Hew RJ, Huitson A, Poloniecki J. The two period crossover trial. Bias 1982; 9: 67–112.
Cleophas TJ. Underestimation of treatment effect in crossover trials. Angiology 1990; 41: 855–864.
Cleophas TJ. (atCrossover studies: a modified analysis with more power). Clin Pharmacol Ther 1993; 53: 515–520.
Cleophas TJ. A simple method for the estimation of interaction bias in crossover studies. J Clin Pharmacol 1990; 30: 1036–1040.
Cleophas TJ. The performance of the two-stage analysis of two-period crossover trials [letter]. Stat Med 1991; 10: 489–495.
Cleophas TJ, Niemeyer MG. Carryover effects in cardiovascular crossover studies: the standard and the clinical analysis. Angiology 1993; 44: 271–279.
Cleophas TJ. Interaction biases in two-period crossover studies: a modified analysis to test with more sensitivity. Biom J 1993; 35: 181–191.
Pocock SJ, Hughes MD, Lee RJ. Statistical problems in the reporting of clinical trials. N Engl J of Med 1987; 317: 426–432.
Packer M. Combined beta-adrenergic and calcium entry blockade in angina pectoris. N Engl J Med 1989; 320: 709–718.
Fleiss JL. A critique of recent research on the two-treatment crossover design. Controll Clin Trials 1989; 10: 237–244.
Grieve AP. A bayesian analysis of the two-period crossover design for clinical trials. Biometrics 1985; 41: 979–990.
Freeman PR. The performance of the two-stage analysis of two-treatment, two-period crossover trials. Stat Med 1989; 8: 1421–1432.
Jones B, Kennard MG. Design and Analysis of Crossover Trials. New York: Routledge, Chapman & Hall, 1989.
Prescott RJ. The comparison of success rates in crossover trials in the presence of an order effect. Appi Stat 30: 9–15, 1981.
Cornfield J, O’Neill RT. Minutes of the food and drug administation, biostatistics and epidemiology Advisory Committee meeting, June 23, 1976.
Strathers AD, Dollery CT. Therapeutic approaches. In “Handbook of Hypertension”. Doyle AE, ed., Elsevier, Amsterdam, 1984, 2–3.
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Cleophas, T.J. (1999). Fundamental Issues of Choosing the Right Type of Trial. In: Human Experimentation. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4663-0_2
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DOI: https://doi.org/10.1007/978-94-011-4663-0_2
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