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Structural Biology and Functional Genomics pp 53–72Cite as

Left-Handed Z-DNA: Structure and Function

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Part of the book series: NATO Science Series ((ASHT,volume 71))

Abstract

Z-DNA is a high energy conformer of B-DNA that forms in vivo during transcription as a result of torsional strain generated by a moving polymerase. An understanding of the biological role of Z-DNA has advanced with the discovery that the RNA editing enzyme double-stranded RNA adenosine deaminase type I (ADAR1) has motifs specific for the Z-DNA conformation. Editing by ADARI requires a double-stranded RNA substrate. In the cases known, the substrate is formed by folding an intron back onto the exon that is targeted for modification. The use of introns to direc.,processing of exons requires that editing occur before splicing. Recognition of Z-DNA by ADARI may allow editing of nascent transcripts to be initiated immediately after transcription, ensuring that editing and splicing are performed in the correct sequence. Structural characterization of the Z-DNA binding domain indicates that it belongs to the winged helix-turn-helix class of proteins and is similar to the globular domain of histone-I-15

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  1. Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA

    Alan Herbert & Alexander Rich

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  1. Life Sciences Division, Los Alamos National Laboratory, Los Alamos, New Mexico, USA

    E. Morton Bradbury

  2. Agricultural Biotechnology Centre, Gödöllõ, Hungary

    Sándor Pongor

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Herbert, A., Rich, A. (1999). Left-Handed Z-DNA: Structure and Function. In: Bradbury, E.M., Pongor, S. (eds) Structural Biology and Functional Genomics. NATO Science Series, vol 71. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4631-9_3

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  • DOI: https://doi.org/10.1007/978-94-011-4631-9_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-5782-7

  • Online ISBN: 978-94-011-4631-9

  • eBook Packages: Springer Book Archive

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