Abstract
The frequency and types of chromosome aberrations in lymphocyte culture of peripheral blood of 24 cosmonauts have been studied. It has been ascertained that the yields of aberrant cells and of chromosome-type aberrations increase after long-term space missions. Proceeding from the linear-quadratic relationship between the effect on dose of high-energy protons, a calibration curve has been obtained after exposure of blood samples in vitro. There was a good agreement between individual doses of space radiation and appropriate doses of 9-GeV protons. It has been concluded that relatively low doses of space radiation result in instability of genome, which, in its turn, may be a cause of an increase in risks of development of the long-term consequences.
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© 1999 Springer Science+Business Media Dordrecht
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Fedorenko, B.S., Petrov, V.M., Druzhinin, S.V. (1999). Chromosome Damages in Cosmonauts’ Blood Lymphocytes as a Measure of Radiation Effect. In: Baumstark-Khan, C., Kozubek, S., Horneck, G. (eds) Fundamentals for the Assessment of Risks from Environmental Radiation. NATO Science Series, vol 55. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4585-5_25
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DOI: https://doi.org/10.1007/978-94-011-4585-5_25
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