Abstract
During recent decades, the availability of assays to measure drug concentrations has resulted in a proliferation of pharmacokinetic studies. On occasion these studies provide tremendous insight into clinical problems. In this session, I will review some basic principles and study designs of pharmacokinetic and pharmacodynamic modeling and explain how these principles can facilitate clinical practice.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Fisher DM, Castagnoli K, Miller RD: Vecuronium kinetics and dynamics in anesthetized infants and children. Clin Pharmacol Ther 1985; 37:402–6
Sheiner LB, Stanski DR, Vozeh S, Miller RD, Ham J: Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine. Clin Pharmacol Ther 1979; 25:358–71
VanderVeen F, Bencini A: Pharmacokinetics and pharmacodynamics of org nc45 in man. Br J Anaesth 1980; 52:37S–41S
Fahey MR, Morris RB, Miller RD, Nguyen T-L, Upton RA: Pharmacokinetics of Org NC45 (Norcuron) in patients with and without renal failure. Br J Anaesth 1981; 53:1049–53
Hughes MA, Glass PS, Jacobs JR: Context-sensitive half-time in multicompartment pharmacokinetic models for intravenous anesthetic drugs. Anesthesiology 1992; 76:334–41
Chauvin M, Sandouk P, Scherrmann JM, Farinotti R, Strumza P, Duvaldestin P: Morphine pharmacokinetics in renal failure. Anesthesiology 1987; 66:327–31
Homer TD, Stanski DR: The effect of increasing age on thiopental disposition and anesthetic requirement. Anesthesiology 1985; 62:714–24
Stanski DR, Maitre PO: Population pharmacokinetics and pharmacodynamics of thiopental: the effect of age revisited. Anesthesiology 1990; 72:412–22
Vuyk J, Hennis PJ, Burm AG, de Voogt JW, Spierdijk J: Comparison of midazolam and propofol in combination with alfentanil for total intravenous anesthesia. Anesth Analg 1990; 71:645–50
Vuyk J, Lim T, Engbers FH, Burm AG, Vletter AA, Bovill JG: Pharmacodynamics of alfentanil as a supplement to propofol or nitrous oxide for lower abdominal surgery in female patients. Anesthesiology 1993; 78:1036–45
Fisher DM, O’Keeffe C, Stanski DR, Cronnelly R, Miller RD, Gregory GA: Pharmacokinetics and pharmacodynamics of d-tubocurarine in infants, children, and adults. Anesthesiology 1982; 57:203–8
Fisher DM, Canfell PC, Spellman MJ, Miller RD: Pharmacokinetics and pharmacodynamics of atracurium in infants and children. Anesthesiology 1990; 73:33–7
Singleton MA, Rosen JI, Fisher DM: Plasma concentrations of fentanyl in infants, children and adults. Can J Anaesth 1987; 34:152–5
Bragg P, Fisher DM, Shi J, Donati F, Meistelman C, Lau M, Sheiner LB: Comparison of twitch depression of the adductor pollicis and the respiratory muscles. Pharmacodynamic modeling without plasma concentrations. Anesthesiology 1994; 80:310–9
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Fisher, D.M. (1999). Is Pharmacokinetics Relevant?. In: Stanley, T.H., Egan, T.D. (eds) Anesthesia for the New Millennium. Developments in Critical Care Medicine and Anesthesiology, vol 34. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4566-4_7
Download citation
DOI: https://doi.org/10.1007/978-94-011-4566-4_7
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-5935-0
Online ISBN: 978-94-011-4566-4
eBook Packages: Springer Book Archive