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Kinetic Considerations in the Selection of an Inhaled Anesthetic

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Anesthesia for the New Millennium

Part of the book series: Developments in Critical Care Medicine and Anesthesiology ((DCCA,volume 34))

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Abstract

Kinetic profiles of many new anesthetic drugs permit a more rapid and precise adjustment of effect, including a more rapid recovery of normal function. Desflurane and, to a lesser extent, sevoflurane fit this mold. These newest inhaled anesthetics differ kinetically from isoflurane and halothane because of their lower solubility in blood (Table), a feature produced by halogenation solely with fluorine [CHF2-O-CHF-CF3 (desflurane); CH2F-O-CH-(CF3)2 (sevoflurane)]. Tissue/gas partition coefficients approximately double from desflurane to sevoflurane to isoflurane to halothane (Table).

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Authors
  1. Edmond I. Eger II
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Editors and Affiliations

  1. Department of Anesthesiology, The University of Utah Medical School, Salt Lake City, Utah, USA

    Theodore H. Stanley  & Talmage D. Egan  & 

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© 1999 Springer Science+Business Media Dordrecht

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Eger, E.I. (1999). Kinetic Considerations in the Selection of an Inhaled Anesthetic. In: Stanley, T.H., Egan, T.D. (eds) Anesthesia for the New Millennium. Developments in Critical Care Medicine and Anesthesiology, vol 34. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4566-4_21

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  • DOI: https://doi.org/10.1007/978-94-011-4566-4_21

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5935-0

  • Online ISBN: 978-94-011-4566-4

  • eBook Packages: Springer Book Archive

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