Abstract
Target controlled drug delivery in anesthesiology is not a new concept but in fact is the clinical basis of all drug delivery in anesthetic practice. That is, the clinician determines a desired level of anesthetic necessary (the target), administers the appropriate amount of agent to achieve the desired anesthetic level (the drug delivery), and then titrates subsequent dose administration based on clinical signs used to indicate the level of anesthetic effect (the control). While this appears to be a relatively straightforward task, the complex relationships which relate the dose of drug given to the pharmacologic effect generated and the degree of ambiguity by which anesthetic level is determined create a challenge even with accurate delivery systems and rapidly acting agents.
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Kern, S.E. (1999). Target Controlled Drug Delivery in Anesthesiology. In: Stanley, T.H., Egan, T.D. (eds) Anesthesia for the New Millennium. Developments in Critical Care Medicine and Anesthesiology, vol 34. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4566-4_13
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DOI: https://doi.org/10.1007/978-94-011-4566-4_13
Publisher Name: Springer, Dordrecht
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