Abstract
We have assessed frequencies of micronucleated lymphocytes in 12307 individuals living in 7 towns in the south of the Kuzbass and Altai regions. Among the towns the majority of individuals with significantly high frequencies of micronucleated lymphocytes were detected in towns adjacent to the Semipalatinsk atomic testing ground (SATG). Pollution of the environment was also caused by the activity of metallurgical plants and coal industry in this region. The greatest genome instability was found in the individuals born in the period of intensive testing on the SATG (from 1949 to 1962). Moreover, we have determined that the residents of the towns adjacent to the SATG have significantly high levels of antibodies to potentially oncogenic Epstein-Barr virus. The considerable Epstein-Barr virus contamination among the residents in the radiation polluted zone around the SATG was supposed to be caused by immunodeficiency disorders in these individuals and induce high frequencies of micronucleated cells.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Ilyinskikh, N.N., Adam, A.M., Novitskii, V.V., Ilyinskikh, E.N. and Ilyin, S. (1995) Mutagenic consequences of radiating pollution of Siberia. Siberian Med. University Press (Russia), p.254.
Ilyinskikh, N.N., Eremich, A.V., Ivanchuk, I.I. and Ilyinskikh, E.N. (1997) Micronucleus test of erythrocytes in the blood of the Altai region residents living near the Semipalatinsk atomic proving ground. Mutation Res. (in press).
Shevchenko, V.A., Snigiryova, G.P., Suskov, I.I., Akayeva, E.A., Elisova, T.N., lofa, E.L., Nilova, I.N., Kostina, L.N., Novitskaya, N.N., Sidorova, V.F. and Nazins, E.D. (1995) The cytogenetics effects among the Altai region population exposed to ionizing radiation resulting from Semipalatinsk nuclear tests. Radiation biology. Radioecology 35, 588–596.
llyinskikh, N.N., Eremich, A.V., lvanchuk, I.I. and Ilyinskikh, E.N. (1996) Micronucleus test of erythrocytes and lymphocytes in the blood of the people living in the radiation pollution zone as a result of the accident at the Siberian chemical plant on April 6, 1993. Mutation Res. 361, 173–178.
Ilyinskikh, N.N., Isaeva, T.M., Ivanchuk, I.I. and Ilyinskikh, E.N. (1996) Breaks of chromosomes in the region of oncogenes and circulation of Epstein-Barr virus among the local population that had been subjected to the effects of radiating deposits. Journal of BUON 1, 101–104.
Ilyinskikh, N.N., Novitsky, V.V., Vanchugova, N.N. and Ilyinskikh, I.N. (1992): “Micronucleus test and cytogenetic instability”, Tomsk University Press (Russia), p.272.
Almassy, Z., Krepinsky, A.B., Bianco, A. and Kotels, G.J. (1987) The present state and perspectives of micronucleus assay in radiation protection: A review. Appl. Radial. lsol. 38, 241–249.
Prosser, J.S., Mognet, L.E., Lloid, D.C. and Edwards, A.A. (1989) Radiation induction of micronuclei in human lymphocytes. Mutation Res. 199, 37–45.
Littlefield, J.G., Sayer, A.M. and Frome, E.J. (1989) Comparison of dose-response parameters for radiation-induced acentric fragments and micronuclei observed in cytokinesis-arrested lymphocytes. Mutagenesis 4, 265–270.
Epstein, M.A. (1985) “Herpesviruses” London: Chapman and Hall, p 337.
Hart, J.W. and Engber-Pedersen, H. (1983) Statistics of the mouse bonnemarrow micronucleus test counting, distribution and evaluation of results. Mutation Res : 11 195–198.
SAS Institute Inc. SAS/STATTMUser’s Guide, Version 6. (1989) Fourth Edition. Cary NC: SAS Institute Inc.
Nichols, W.W. (1963) Relationship of viruses, chromosomes and carcinogenesis. Hereditas 50, 53–80.
Ilyinskikh, N.N., Bocharov, Ye F. and Ilyinskikh, I.N. (1982) “Infection mutagenesis”, Novosibirsk: Nauka (Russia), p,185.
Ilyinskikh, N.N., Ilyinskikh, I.N. and Bocharov, Ye F. (1984) “Cytogenetic homeostasis and immunity”, Novosibirsk: Nauka (Russia), p.256.
Dillner, J. (1986) An Epstein-Barr virus determined nuclear antigen partly encoded by the transformation - associated BAM WYN region of EBV DNA: preferential expression in lymphoblastoid cell lines. Proc. Nat. Acad Sci USA 83, 6641–6645.
Petti, L. and Kiefl; E. (1988) A sixth Epstein-Barr virus nuclear protein (EBNA 38) is expressed in latently infected growth - transformated lymphocytes. J. Virol. 62,2173–2178.
Rowe, D.T., Forrel, J.J. and Milled, G. (1987) Novel nuclear antigens recognized by human sera in lymphocytes latently infected by Epstein-Barr virus. Virology 156,153–162.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Ilyinskikh, E.N., Ilyinskikh, N.N., Ilyinskikh, I.N. (1999). Genetic and Oncogenic Consequences of Chemical and Radiation Pollution of the Kuzbass and Altai Regions. In: Peakall, D.B., Walker, C.H., Migula, P. (eds) Biomarkers: A Pragmatic Basis for Remediation of Severe Pollution in Eastern Europe. NATO Science Series, vol 54. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4550-3_6
Download citation
DOI: https://doi.org/10.1007/978-94-011-4550-3_6
Publisher Name: Springer, Dordrecht
Print ISBN: 978-0-7923-5644-8
Online ISBN: 978-94-011-4550-3
eBook Packages: Springer Book Archive