Advertisement

Contrast agents in cardiac MRI

Chapter
  • 171 Downloads
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 215)

Abstract

In MRI studies, a contrast agent is defined as a substance that, once injected to the patient, modifies selectively the signal intensity of a particular anatomical structure by changing relaxation properties of tissues. Different magnetic substances have been tested, including manganese, gadolinium, dysprosium, and iron oxide, their effects depending on their pharmacokinetic properties and predominant action on proton relaxation.

Keywords

Contrast Agent Myocardial Perfusion Magn Reson Image Echo Planar Imaging Normal Myocardium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Raymond HW, Zwiebel WJ, Swartz JD, eds. Vascular imaging with CT and MR. Semin Ultrasound CT MR 1996; 17: 279–411.Google Scholar
  2. 2.
    Prince MR, Grist TM, Debatin JF, eds. 3D Contrast MR Angiography. New York, Springer; 1997.Google Scholar
  3. 3.
    Brasch RC, Weinmann HJ, Wesbey GE. Contrast-enhanced NMR imaging: animal studies using gadolinium-DTPA complex. Am J Roentgenol AJR 1984; 142: 625–30.CrossRefGoogle Scholar
  4. 4.
    Funari M, Fujita N, Peck WW, Higgins CB. Cardiac tumors: assessment with Gd-DTPA enhanced MR imaging. J Comput Assist Tomogr 1991; 15: 953–8.PubMedCrossRefGoogle Scholar
  5. 5.
    Forsgren G, Nyman R, Glimelius B, Hagberg H, Rehn S, Hemmingsson A. Gd-DTPA-enhanced MR imaging in mediastinal Hodgkin’s disease. Acta Radiol 1994; 35: 564–9.PubMedGoogle Scholar
  6. 6.
    Matsuoka H, Hamada M, Honda T, et al. Morphologic and histologic characterization of cardiac myxomas by magnetic resonance imaging. Angiology 1996; 47: 693–8.PubMedCrossRefGoogle Scholar
  7. 7.
    Semelka RC, Shoenut JP, Wilson ME, Pellech AE, Patton JN. Cardiac masses: signal intensity features on spin-echo, gradient-echo, gadolinium-enhanced spin-echo, and TurboFLASH images. J Magn Reson Imaging 1992; 2: 415–20.PubMedCrossRefGoogle Scholar
  8. 8.
    Saeed M, Wendland MF, Higgins CB. Contrast media for MR imaging of the heart. J Magn Reson Imaging 1994; 4: 269–79.PubMedCrossRefGoogle Scholar
  9. 9.
    Pettigrew R, Oshinski J, Dixon WT. Magnetic resonance imaging techniques for assessing myocardial perfusion. In: Higgins CB, Ingwall JS, Pohost GM, eds. Current and future applications of magnetic resonance in cardiovascular disease. New York: Futura; 1998: 37–52.Google Scholar
  10. 10.
    Crnac J, Schmidt MC, Theissen P, Sechtem U. Assessment of myocardial perfusion by magnetic resonance imaging. Herz 1997; 22: 16–28.PubMedCrossRefGoogle Scholar
  11. 11.
    Manning WJ, Atkinson DJ, Grossman W, Paulin S, Edelman RR. First-pass nuclear magnetic resonance imaging studies using gadolinium-DTPA in patients with coronary artery disease. J Am Coll Cardiol 1991; 18: 959–65.PubMedCrossRefGoogle Scholar
  12. 12.
    Schaefer S, van Tyen R, Saloner D. Evaluation of myocardial perfusion abnormalities with gadolinium-enhanced snapshot MR imaging in humans. Work in progress. Radiology 1992; 185: 795–801.Google Scholar
  13. 13.
    Keijer JT, van Rossum AC, van Eenige MJ, et al. Semiquantitation of regional myocardial blood flow in normal human subjects by first-pass magnetic resonance imaging. Am Heart J 1995; 130: 893–901.PubMedCrossRefGoogle Scholar
  14. 14.
    van Dijkman PR, van der Wall EE, de Roos A, et al. Acute, subacute, and chronic myocardial infarction: quantitative analysis of gadolinium-enhanced MR images. Radiology 1991; 180: 147–51.PubMedGoogle Scholar
  15. 15.
    Holman ER, van Jonbergen HP, van Dijkman PR, van der Laarse A, de Roos A, van der Wall EE. Comparison of magnetic resonance imaging studies with enzymatic indexes of myocardial necrosis for quantification of myocardial infarct size. Am J Cardiol 1993; 71: 1036–40.PubMedCrossRefGoogle Scholar
  16. 16.
    Van Rossum AC, Visser FC, Van Eenige MJ, et al. Value of gadolinium-diethylene-triamine penta-acetic acid dynamics in magnetic resonance imaging of acute myocardial infarction with occluded and reperfused coronary arteries after thrombolysis. Am J Cardiol 1990; 65: 845–51.PubMedCrossRefGoogle Scholar
  17. 17.
    de Roos A, Matheijssen NA, Doornbos J, van Dijkman PR, van Voorthuisen AE, van der Wall EE. Myocardial infarct size after reperfusion therapy: assessment with Gd-DTPA-enhanced MR imaging. Radiology 1990; 176: 517–21.PubMedGoogle Scholar
  18. 18.
    Yokota C, Nonogi H, Miyazaki S, et al. Gadolinium-enhanced magnetic resonance imaging in acute myocardial infarction. Am J Cardiol 1995; 75: 577–81.PubMedCrossRefGoogle Scholar
  19. 19.
    Lima JA, Judd RM, Bazille A, Schulman SP, Atalar E, Zerhouni EA. Regional heterogeneity of human myocardial infarcts demonstrated by contrast-enhanced MRI. Potential mechanisms. Circulation 1995; 92: 1117–25.PubMedCrossRefGoogle Scholar
  20. 20.
    Dendale P, Franken PR, Meusel M, van der Geest R, de Roos A. Distinction between open and occluded infarct-related arteries using contrast-enhanced magnetic resonance imaging. Am J Cardiol 1997; 80: 334–6.PubMedCrossRefGoogle Scholar
  21. 21.
    Dendale P, Franken PR, Block P, Pratikakis Y, De Roos A. Contrast enhanced and functional magnetic resonance imaging for the detection of viable myocardium after infarction. Am Heart J 1998; 135: 875–80.PubMedCrossRefGoogle Scholar
  22. 22.
    Kramer CM, Rogers WJ, Geskin G, et al. Usefulness of magnetic resonance imaging early after acute myocardial infarction. Am J Cardiol 1997; 80: 690–5.PubMedCrossRefGoogle Scholar
  23. 23.
    The clinical role of magnetic resonance in cardiovascular disease. Task Force of the European Society of Cardiology, in collaboration with the Association of European Paediatric Cardiologists. Eur Heart J 1998; 19: 19–39.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1999

Authors and Affiliations

There are no affiliations available

Personalised recommendations