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Hepatolithiasis, cystic dilatation of bile ducts and the variable risk of cholangiocarcinoma. Re-evaluation of an old problem

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Summary

Patients and methods A review of the most recent findings concerning hepatolithiasis, cystic bile duct dilatation and the variable risk of cholangiocarcinoma is reported. In particular, data are reported concerning an Italian series of 107 out of 6745 consecutive patients with bile tract surgery, who had gallstones (GS) within the intrahepatic ducts. Fifteen of them had cystic dilatation of bile ducts (CBDD). All these patients had systematic bile culture and stone analysis by IR spectroscopy. The 107 patients underwent a follow-up period ranging between 1 and 20 years.

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References

  1. Kim M-H, Sekijima J, Lee SP. Primary intraheaptic stones. Am J Gastroenterol 1995; 90: 540–548.

    PubMed  CAS  Google Scholar 

  2. Nakayama F, Soloway RD, Nakama T, Miyazaki K, Ichimiya H, Sheen PC, Ker CG. Hepatolithiasis in East Asia: retrospective study. Dig Dis Sci 1986; 31: 21–26.

    Article  PubMed  CAS  Google Scholar 

  3. Cetta F. Bile infection documented as initial event in the pathogenesis of brown pigment biliary stones. Hepatology 1986; 6: 482–489.

    Article  PubMed  CAS  Google Scholar 

  4. Cetta F. The role of bacteria in pigment gallstone disease. Ann Surg 1991; 213: 315–326.

    Article  PubMed  CAS  Google Scholar 

  5. Cetta F. Do surgical and endoscopic sphincterotomy prevent or facilitate recurrent common duct stone formation? Arch Surg 1993; 128: 329–336.

    Article  PubMed  CAS  Google Scholar 

  6. Cetta F, Lombardo F, Cariati A. The role of the content (decreased level of apolìpoprotein Al) and the container (bile duct stricture, sectorial dilatation of the ducts determining bile stasis) in the pathogenesis of hepatolithiasis, either pigment or cholesterol. Hepatology 1994; 19: 1539–1541.

    Article  PubMed  CAS  Google Scholar 

  7. Cetta F, Lombardo F, Giubbolini M, Malet P. Hepatolithiasis: i) frequency, stone type and composition in a consecutive series of 1350 surgical patients. Gastroenterology 1993; 104: A 355.

    Google Scholar 

  8. Cetta F, Lombardo F, Baldi C, Cappelli A. Hepatolithiasis: a Western experience. Suggestion for pathogenesis. In Bresadola F Ed. “Proceedings 18” Cong. SIRC” New Magazine Publ 1994; 239–246.

    Google Scholar 

  9. Cetta F, Lombardo F, Giubbolini M, Baldi C, Cariati A Classification of gallstones and epidemiologic studies. Dig Dis Sci 1995; 40: 2189–2191.

    Article  PubMed  CAS  Google Scholar 

  10. Matsumoto Y, Fujii H, Yoshioka M, Sekikawa T, Wada T, Yamamoto M, Eguchi H, Sugahara K. Biliary strictures as a cause of primary intrahepatic bile duct stones. World J Surg 1986; 10: 867–875.

    Article  PubMed  CAS  Google Scholar 

  11. Cetta F. Bile stasis due to bile duct stricture precedes, not follows, the formation of primary intrahepatic stones and plays a basic role in their pathogenesis. Am J Gastroenterol 1996; 91: 2451–2452.

    PubMed  CAS  Google Scholar 

  12. Shoda J, He B, Tanaka N, Matsuzaki Y, Yamamori S, Osuga T. Primary dual defect of cholesterol and bile acid metabolism in liver of patients with intrahepatic calculi. Gastroenterology 1995; 108: 1534–1546.

    Article  PubMed  CAS  Google Scholar 

  13. Cetta F, Lombardo F, Giubbolini M, Baldi C, Cariati A, Malet P. Hepatolithiasis and cholesterol and bile acid metabolism. Gastroenterology 1996; 110: 963–970.

    Article  PubMed  CAS  Google Scholar 

  14. Uno K, Tsuchida Y, Kawarasaki H, Ohniya H, Honna T. Development of intrahepatic cholelithiasis long after primary excision of choledochal cysts. J Am Coll Surg 1996; 183: 583–588.

    PubMed  CAS  Google Scholar 

  15. Ando H, Ito T, Kaneko K, Seo T. Congenital stenosis of the intrahepatic bile duet associated with choledochal cysts. J Am Coll Surg 1995; 181: 426–430.

    PubMed  CAS  Google Scholar 

  16. Cetta F, Montalto G, Nuzzo G. Recurrent hepatolithiasis after primary excision of choledochal cysts. J Am Coll Surg 1997; 185: 197–201.

    Article  Google Scholar 

  17. Cetta F, Montalto G, Zuckermann M, Cetta D. Hemobilia, infection, bile stasis and intrahepatic stones in liver transplant recipients. Surgery 1998; 123: 115–117.

    Article  PubMed  CAS  Google Scholar 

  18. Todani T, Watanabe Y, Narusue M, Tabuchi K, Okajima K. Congenital bile duct cysts: classification, operative procedures, and review of thirty-seven cases including cancer arising from choledochal cyst. Am J Surg 1997; 134: 263–269.

    Article  Google Scholar 

  19. Todani T, Tabuchi K, Watanabe Y, Kobayashi T. Carcinoma arising in the wall of congenital bile duct cysts. Cancer 1979; 44: 1134–1141.

    Article  PubMed  CAS  Google Scholar 

  20. Irwin ST, Morison JE. Congenital cyst of the common bile duct containing stones and undergoing cancerous change. Br J Surg 1944; 32: 319–321.

    Article  Google Scholar 

  21. Kasai M, Asakura Y, Taira Y. Surgical treatment of choledochal cyst. Ann Surg 1970; 172: 844–851.

    Article  PubMed  CAS  Google Scholar 

  22. Nagorney DM, McIlrath DC, Adson MA Choledochal cysts in adults. Clinical management. Surgery 1984; 96: 656–663.

    PubMed  CAS  Google Scholar 

  23. Rossi RL, Silverman ML, Braasch JW, Munson JL, Remine SG. Carcinomas arising in cystic conditions of the bile ducts. A clinical and pathologic study. Ann Surg 1987; 205: 377–384.

    Article  PubMed  CAS  Google Scholar 

  24. Dayton MT, Longmire WP, Tompkins RK. Caroli’s disease: A premalignat condition? Am J Surg 1983; 145: 41–48.

    Article  PubMed  CAS  Google Scholar 

  25. Barros JL, Polo JR, Sanabia J, Garcia-Sabrido JL, Gomez-Lorenzo FJ. Congenital cystic dilatation of the intrahepatic bile ducts (Caroli’s disease): report of a case and review of the literature. Surgery 1979; 85: 589–592.

    PubMed  CAS  Google Scholar 

  26. Ribeiro A, Reddy RK, Bernstein D, Jeffers L, Schiff ER. Caroli’s syndrome in twin sisters. Am J Gastroenterol 1996; 91: 1024–1026.

    PubMed  CAS  Google Scholar 

  27. Kimura K, Ohto M, Saisho H, Unozawa T, Tsuciya Y, Morita M, Ebara M, Matsutani S, Okuda K. Association of gallbladder carcinoma and anamalous pancreaticobiliary ductal union. Gastroenterology 1985; 89: 1258–1265.

    PubMed  CAS  Google Scholar 

  28. Kinoshita H, Nagata E, Hirohashi K, Sakai K, Kobaiashi Y. Carcinoma of the gallbladder with an anomalous connection between the choledochus and the pancreatic duct. Cancer 1984; 54: 762–769.

    Article  PubMed  CAS  Google Scholar 

  29. Tomono H, Nimura Y, Aono K, Nakashima I, Iwamoto T, Nakashima N. Point mutation of the c-Ki-ras gene in carcinoma and atypical epithelium associated with congenital biliary dilatation. Am J Gastroenterol 1996; 91: 1211–1214.

    PubMed  CAS  Google Scholar 

  30. Komi N, Tamura T, Miyoshi Y, Kunitomo K, Udaka H, Takehara H. Nationwide surgery of cases of choledochal cysts: analysis of coexistent anomalies, complications, and surgical treatment in 645 cases. Surg Gastroenterol 1984; 3: 69–73.

    PubMed  CAS  Google Scholar 

  31. Baumann R, Wittersheim C, Dron K. Dilatations kystiques congénitales du cholèdoque. Anomalie de la jonction bilio-pancréatique. Hépato-Gastro 1997; 4: 281–286.

    Google Scholar 

  32. Lipsett P, Pitt HA, Colombani PM, Biotnott JK, Cameron JL. Choledochal cyst disease. A changing pattern of presentation. Ann Surg 1994; 220: 644–652.

    Article  PubMed  CAS  Google Scholar 

  33. Chijiiwa K, Koga A. Surgical management and long-term follow-up of patients with choledochal cysts. Am J Surg 1993; 165: 238–242.

    Article  PubMed  CAS  Google Scholar 

  34. Schudamore CH, Hemming AW, Teare JP, Fache JS, Erb SR, Watkinson AF. Surgical management of choledochal cysts. Am J Surg 1994; 167: 497–500.

    Article  Google Scholar 

  35. Hewitt PM, Kridge JEJ, Bormann PC, Terblanche J. Choledochal cysts in adults. Br J Surg 1995; 82: 382–385.

    Article  PubMed  CAS  Google Scholar 

  36. Chaudhary A, Dhar P, Sachdev A, Kumar N, Vij JC, Sarin SK, Broor SL, Sharma SS. Choledochal cysts-difference in children and adults. Br J Surg 1996; 83: 186–188.

    Article  PubMed  CAS  Google Scholar 

  37. Lopez RR, Pinson WM, Campbell JR, Harrison M, Katon RM. Variation in management based on type of choledochal cyst. Am J Surg 1991; 161: 612–615.

    Article  PubMed  CAS  Google Scholar 

  38. Nagorney DM, McIlrath DC, Adson MA Choledochal cysts in adults: clinical management. Ann Surg 1994; 94: 656–663.

    Google Scholar 

  39. Stain SC, Guthrie CR, Yellin AE, Donovan AJ. Choledochal cyst in the adult. Ann Surg 1983; 52: 2086–2088.

    Google Scholar 

  40. Todani T, Watanabe Y, Toki A, Urushihara N. Carcinoma related to choledochal cysts with internal drainage operations. Surg Gynecol Obstet 1987; 164: 61–64.

    PubMed  CAS  Google Scholar 

  41. Benhidjeb T., Munster B., Ridwelski K., Rudolph B., Mau H., Lippert H.: Cystic dilatation of the common bile duct: surgical treatment and long-term results. Br. J. Surg. 1994; 81: 433–436.

    Article  PubMed  CAS  Google Scholar 

  42. Takiff H., Stone M., Fonkalsrud E.W.: Choledochal cysts: results of primary surgery and need for reoperation in young patients. Am. J. Surg. 1985; 150: 141–145.

    Article  PubMed  CAS  Google Scholar 

  43. Yamaguchi M.: Congenital choledochal cysts. Analysis of 1.433 patients in the Japanese literature. Am. J. Surg. 1980; 140: 653–657.

    Article  PubMed  CAS  Google Scholar 

  44. Ando H., Ito T., Kaneko K., Seo T., Ito F.: Intrahepatic bile duct stenosis causing intrahepatic calculi formation following excision of a choledochal cyst. J. Am. Coll. Surg. 1996; 183: 56–60.

    PubMed  CAS  Google Scholar 

  45. Ando H., Kaneko K., Ito T., Watanabe Y., Seo T., Harada T., Ito F., Nagaya M., Sugito T.: Complete excision of the intrapancreatic portion of choledochal cysts. J. Am. Coll. Surg. 1996; 183: 317–321.

    PubMed  CAS  Google Scholar 

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© 1999 Springer Science+Business Media Dordrecht

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Cetta, F., Montalto, G., Baldi, C., Zuckermann, M., Nuzzo, G. (1999). Hepatolithiasis, cystic dilatation of bile ducts and the variable risk of cholangiocarcinoma. Re-evaluation of an old problem. In: Zanella, E. (eds) Advances in Abdominal Surgery. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4469-8_7

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  • DOI: https://doi.org/10.1007/978-94-011-4469-8_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5914-5

  • Online ISBN: 978-94-011-4469-8

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