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Pancreatic islet cell-transplantation

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Advances in Abdominal Surgery

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Summary

Pancreatic islet cell-transplantation is currently used in major transplant centers as an alternative to total pancreas transplant, in the surgical treatment of insulin-dependent diabetes mellitus. Pancreatic islet cell transplantation was first considered in the past century, but the first satisfactory results were obtained in 1990, after Ricordi had developed an automated procedure for islet isolation from the surrounding parenchyma. While developing an effective isolation technique, several islet purification procedures have been tested, the most effective of which has been found to be the one based on the use of Ficoll solutions with different density gradients. The transplanted cells must necessarily be introduced into a heterotopic site, the best one so far identified being the liver. Almost all clinically successful islet cell-transplantationshave been obtained by means of intraportal islet embolization. Pancreatic islet cells can be transplanted in association with other organs, and the best results have been obtained with simultaneous kidney-islet celltransplantation. We shall present an overview on this subject based on our experience as well as on the experience of the most important centers included in the International Registry.

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Authors and Affiliations

  1. Department of Surgery and Anesthesiology, 1st Surgical Clinics, University of Bologna, Bologna, Italy

    Domenico Marrano, Vincenzo Maria Greco & Andrea Conti

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  1. Domenico Marrano
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  2. Vincenzo Maria Greco
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  3. Andrea Conti
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Editors and Affiliations

  1. Department of Surgery, University of Rome “Tor Vergata”, Rome, Italy

    Everardo Zanella (Professor of Surgery and Chairman) (Professor of Surgery and Chairman)

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© 1999 Springer Science+Business Media Dordrecht

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Marrano, D., Greco, V.M., Conti, A. (1999). Pancreatic islet cell-transplantation. In: Zanella, E. (eds) Advances in Abdominal Surgery. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4469-8_20

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  • DOI: https://doi.org/10.1007/978-94-011-4469-8_20

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5914-5

  • Online ISBN: 978-94-011-4469-8

  • eBook Packages: Springer Book Archive

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