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Antioxidants and Cardiovascular Disease pp 19–46Cite as

Pathogenesis of Atherosclerosis

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 233))

Abstract

Atherosclerosis is the most prevalent disease of modern society. Coronary atherosclerosis and its thrombotic complications are responsible for over one half million deaths annually, and countless other complications, in North America alone. Coronary plaques appear early in ones life, by the end of the second decade asymptomatic atherosclerotic lesions are present in most people. As these lesions grow they may eventually limit blood flow to the myocardium resulting in chronic ischemic syndromes. If progression is rapid as in the case of plaque rupture accompanied by superimposed thrombosis an acute ischemic syndrome such as unstable angina, myocardial infarction, or sudden death may result from the sudden narrowing or occlusion of the artery [1,2].

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  1. Richard Gallo
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  2. Valentin Fuster
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  1. Montreal Heart Institute, Research Center and Department of Medicine, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada

    Jean-Claude Tardif  & Martial G. Bourassa  & 

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Gallo, R., Fuster, V. (2000). Pathogenesis of Atherosclerosis. In: Tardif, JC., Bourassa, M.G. (eds) Antioxidants and Cardiovascular Disease. Developments in Cardiovascular Medicine, vol 233. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4375-2_2

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  • DOI: https://doi.org/10.1007/978-94-011-4375-2_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5881-0

  • Online ISBN: 978-94-011-4375-2

  • eBook Packages: Springer Book Archive

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