Abstract
The myocardium is highly metabolically active and rich in reactive oxygen and nitrogen species. Reactive oxygen species (ROS), a byproduct of aerobic metabolism, are handled in the myocardium by soluble and enzymatic antioxidant systems. Oxidative stress can result from abnormally high levels of ROS production or insufficient antioxidant defenses. When the production of ROS exceeds the capacity of antioxidant defense systems, there is an increase in ‘oxidative stress’.
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Sawyer, D.B., Colucci, W.S. (2000). Role of Oxidative Stress, Cytokines, and Apoptosis in Myocardial Dysfunction. In: Tardif, JC., Bourassa, M.G. (eds) Antioxidants and Cardiovascular Disease. Developments in Cardiovascular Medicine, vol 233. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4375-2_13
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