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Abstract

Atrial fibrillation is the most common sustained cardiac arrhythmia encountered in clinical practice. It accounts for more than 300,000 hospital admissions annually in the Unit ed States [1]. The prevalence of atrial fibrillation increases with age, (e.g., 0.5% at age 50–59 years and up to 9% at 80–89 years) [2], and, in addition, it increases with the de velopment of cardiac and non-cardiac conditions such as rheumatic heart disease, hypertension, atherosclerotic heart disease, cardiomyopathy, pericarditis, and hyperthyroidism. [3–5]. Atrial fibrillation is also noted to be more prevalent in men than in women [6].

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References

  1. American Heart Association. Heart and Stroke Facts: Statistical Supplement. pg 14, 1996.

    Google Scholar 

  2. Vaziri SM, Larson MG, et al.: Echocardiographic predictors of nonrheumatic atrial fibrillation: the Framingham Heart Study. Circulation 89:724–730, 1994.

    PubMed  CAS  Google Scholar 

  3. Kannel WB, Abbott RD, Savage DD, McNamara PM: Epidemiologic features of chronic atrial fibrillation: the Framingham study. N Engl J Med 306:1018–1022, 1982.

    PubMed  CAS  Google Scholar 

  4. Benjamin EJ, Levy D, Vaziri SM, et al.: Independent risk factors for atrial fibrillation in a populationbased cohort. The Framingham Heart Study. JAMA 271:840–844, 1994.

    PubMed  CAS  Google Scholar 

  5. Wolf PA, Benjamin EJ, Belanger AJ, et al.: Secular trends in the prevalence of atrial fibrillation: The Framingham Study. Am Heart J 131:790–795, 1996.

    PubMed  CAS  Google Scholar 

  6. Feinberg WM, Blackshear JL, Laupacis A, et al.: Prevalence, age distribution and gender in patients with atrial fibrillation; analysis and implications. Arch Intern Med 155:469–473, 1995.

    PubMed  CAS  Google Scholar 

  7. Pritchett E: Management of atrial fibrillation. N Engl J Med 326:1264–1271, 1992.

    PubMed  CAS  Google Scholar 

  8. Sohara H, Amitani S, et al.: Atrial fibrillation activates platelets and coagulation in a time-dependent manner: a study in patients with paroxysmal atrial fibrillation. J Am Coll Cardiol 29:106–112, 1997.

    PubMed  CAS  Google Scholar 

  9. Carson PE, Johnson GR, Dunkman WB, et al.: The influence of atrial fibrillation on prognosis in mild to moderate failure. The V-HeFT Studies. The V-HeFT VA Cooperative Studies Group. Circulation 87:VI–102–VI–110, 1993.

    Google Scholar 

  10. Middlekauff HR, Stevenson WG, Stevenson LW: Prognostic significance of atrial fibrillation in advanced heart failure. A study of 390 patients. Circulation 84:40–48, 1991.

    PubMed  CAS  Google Scholar 

  11. Wolf PA, Kannel WB, McGee DL, et al.: Duration of atrial fibrillation and imminence of stroke: the Framingham study. Stroke 14:664–667, 1983.

    PubMed  CAS  Google Scholar 

  12. Wolf PA, Abbott RD, Kannel WB: Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke 22:983–988, 1991.

    PubMed  CAS  Google Scholar 

  13. Wolf PA, Abbott RD, Kannel WB: Atrial fibrillation: a major contributor to stroke in the elderly. The Framingham Study. Arch Intern Med 147:1561–1564, 1987.

    PubMed  CAS  Google Scholar 

  14. Sherman DG, Goldman L, Whiting RB, et al.: Thromboembolism in patients with atrial fibrillation. Arch Neurol 41:708–710, 1984.

    PubMed  CAS  Google Scholar 

  15. Lev M, McMillan JB. Aging changes in the heart. In: Bourne GH, ed. Structural Aspects of Aging. London: Pittman Medical, 325–349: 1961.

    Google Scholar 

  16. McMillan JB, Lev M: The aging heart: Endocardium. J Gerontol 14:268–283, 1959.

    Google Scholar 

  17. McMillan JB, Lev M. The aging heart. Myocardium and epicardium. In: Shock NW, ed. Biologic Aspects of Aging. New York, NY: Columbia University Press, 1963–1973: 1962.

    Google Scholar 

  18. Frustaci A, Chimenti C, Bellocci F, et al.: Histological substrate of atrial biopsies in patients with lone atrial fibrillation. Circulation 96:1180–1184, 1997.

    PubMed  CAS  Google Scholar 

  19. Probst P, Goldschlager N, Selzer A: Left atrial size and atrial fibrillation in mitral stenosis: factors influencing their relationship. Circulation 48:1282–1287, 1973.

    PubMed  CAS  Google Scholar 

  20. Thiedmann KU, Ferrans VJ: Left atrial ultrastructure in mitral valvular disease. Am J Pathology 89:575–604, 1977.

    Google Scholar 

  21. Cushing EH, Feil H, Stanton EJ, Wartman WB: Infarction of cardiac auricles (atria): clinical, pathological, and experimental studies. Br Heart J 4:417–434, 1942.

    Google Scholar 

  22. Soderstrom N: Myocardial infarction and mural thrombosis in the atria of the heart. Acta Med Scand Suppl:217, 1948.

    Google Scholar 

  23. Cameron A, Schwartz MJ, Kronmal RA, Kosinski AS: Prevalence and significance of atrial fibrillation in coronary artery disease (CASS registry). Am J Cardiol 61:714–717, 1988.

    PubMed  CAS  Google Scholar 

  24. Kannel WB, Abbott RD, Savage DD, McNamara PM: Coronary heart disease and atrial fibrillation: the Framingham Study. Am Heart J 106:389–396, 1983.

    PubMed  CAS  Google Scholar 

  25. James TN: Pericarditis and the sinus node. Arch Intern Med 110:305–311, 1962.

    PubMed  CAS  Google Scholar 

  26. Spodick DH: Arrhythmias during acute pericarditis; a prospective study in 100 consecutive cases. JAMA 5:39–41, 1976.

    Google Scholar 

  27. Ohtani K, Yutani C, Nagatta S, et al.: High prevalence of atrial fibrosis in patients with dilated cardiomyopathy. J Am Call Cardiol 25:1162–1169, 1995.

    CAS  Google Scholar 

  28. Dubrey S, Pollak A, Skinner M, Falk RH: Atrial thrombi occurring during sinus rhythm in cardiac amyloidosis: evidence for atrial electromechanical dissociation. Br Heart J 74:541–544, 1995.

    PubMed  CAS  Google Scholar 

  29. Sung RJ, Castellanos A, et al.: Mechanisms of spontaneous alternation between reciprocating tachycardia and atrial flutter-fibrillation in the Wolff-Parkinson-White syndrome. Circulation 56:409–416, 1977.

    PubMed  CAS  Google Scholar 

  30. Hurwitz JL, German LD, et al.: Occurrence of atrial fibrillation in patients with paroxysmal supraventricular tachycardia due to atrioventricular nodal reentry. Pacing Clin Electrophysiol 13:705–710, 1990.

    PubMed  CAS  Google Scholar 

  31. Goette A, Honeycutt C, Langberg JJ: Electrical remodeling in atrial fibrillation. Time course and mechanisms. Circulation 94:2968–2974, 1996.

    PubMed  CAS  Google Scholar 

  32. Sanfilippo AJ, Abascal VM, Sheehan M, et al.: Atrial enlargement as a consequence of atrial fibrillation. A prospective echocardiographic study (Abstract). Circulation 92:1–114, 1995.

    Google Scholar 

  33. Wijffels MC, Kirchhof CJ, Dorland R, Allessie MA: Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats. Circulation 92:1954–1968, 1995.

    PubMed  CAS  Google Scholar 

  34. Wijffels MC, Kirchhof CJ, Dorland R, et al.: Electrical remodeling due to atrial fibrillation in chronically instrumented conscious goats: roles of neurohumoral changes, ischemia, atrial stretch, and high rate of electrical activation. Circulation 96:3710–3720, 1997.

    PubMed  CAS  Google Scholar 

  35. Morillo CA, Klein GJ, et al.: Chronic rapid atrial pacing. Structural, functional, and electrophysiological characteristics of a new model of sustained atrial fibrillation. Circulation 91:1588–1595, 1995.

    PubMed  CAS  Google Scholar 

  36. Sun H, Gaspo R, Leblanc N, Nattel S: Cellular mechanisms of atrial contractile dysfunction caused by sustained atrial tachycardia. Circulation 98:719–727, 1998.

    PubMed  CAS  Google Scholar 

  37. Yue L, Feng J, Gaspo R, et al.: Ionic remodeling underlying action potential changes in a dog model of atrial fibrillation. Circulation Research 81:512–525, 1997.

    PubMed  CAS  Google Scholar 

  38. Shinbane JS, Wood MA, Jensen DN, et al.: Tachycardia-induced cardiomyopathy: a review of animal models and clinical studies. J Am Coll Cardiol 29:709–715, 1997.

    PubMed  CAS  Google Scholar 

  39. Ausma J, Wijffels M, van Eys G, et al.: Dedifferentiation of atrial cardiomyocytes as a result of chronic atrial fibrillation. Am J Pathol 151:985–997, 1997.

    PubMed  CAS  Google Scholar 

  40. Ausma J, Wijffels M, Thone F, et al.: Structural changes of atrial myocardium due to sustained atrial fibrillation in the goat. Circulation 96:3157–3163, 1997.

    PubMed  CAS  Google Scholar 

  41. Asher CR, Chung MR, Eagle KA, et al.: Atrial fibrillation following cardiac surgery. In: Falk R, Podrid P, eds. Atrial fibrillation mechanisms and management. 2nd ed: Lippincott-Raven, 183–204.: 1997.

    Google Scholar 

  42. Hogue CW, Domitrovich PP, Stein PK, et al.: RR interval dynamics before atrial fibrillation in patients after coronary artery bypass graft surgery. Circulation 98:429–434, 1998.

    PubMed  Google Scholar 

  43. Andrews TC, Reimold SC, Berlin JA, Antman EM: Prevention of supraventricular arrhythmias after coronary artery bypass surgery. Circulation 84:111236–111244, 1991.

    Google Scholar 

  44. Kaiman JM, Munawar M, Howes LG, et al.: Atrial fibrillation after coronary artery bypass grafting is associated with sympathetic activation. Ann Thorac Surg 60:1707–1715, 1995.

    Google Scholar 

  45. Klein L, Levy GS: New perspectives on thyroid hormone, catecholamines, and the heart. Am J Med 76:167, 1984.

    PubMed  CAS  Google Scholar 

  46. Garrey WE: The nature of fibrillary contraction of the heart-its relation to tissue mass and form. Am J Physiol 33:397–414, 1914.

    Google Scholar 

  47. Moe GK, Abildskov JA: Experimental and laboratory reports: Atrial fibrillation as a self-sustaining arrhythmia independent of focal discharge. Am Heart J 58:59–70, 1959.

    PubMed  CAS  Google Scholar 

  48. Moe GK, Rheinboldt WC, et al.: A computer model of atrial fibrillation. Am Heart J 67:200, 1964.

    PubMed  CAS  Google Scholar 

  49. Scherf D: Studies on auricular tachycardia caused by aconitine administration. Proc Soc Exp Biol Med 64:233–239, 1947.

    PubMed  CAS  Google Scholar 

  50. Jais P, Haissaguerre M, Shah DC, et al.: A focal source of atrial fibrillation treated by discrete radiofrequency ablation. Circulation 95:572–576, 1997.

    PubMed  CAS  Google Scholar 

  51. Mines GR: On dynamic equilibrium in the heart. J Physiol (London) 46:349–383, 1913.

    CAS  Google Scholar 

  52. Allessie MA, Bonke FI, Schopman FJ: Circus movement in rabbit atrial muscle as a mechanism of tachycardia. III. The “leading circle” concept: a new model of circus movement in cardiac tissue without the involvement of an anatomical obstacle. Circ Res 41:9–18, 1977.

    PubMed  CAS  Google Scholar 

  53. Task Force of the Working Group on Arrhythmias of the European Society of Cardiology: The Sicilian Gambit: A new approach to the classification of antiarrhythmic drugs based on their actions on arrhythmogenic mechanisms. Circulation 84:1831–1851, 1991.

    Google Scholar 

  54. Lai WT, Huycke EC, Keung EC, et al.: Electrophysiologic manifestations of the excitable gap of orthodromic atrioventricular reciprocating tachycardia demonstrated by single extra-stimulation. Am J Cardiol 63:545–555, 1989.

    PubMed  CAS  Google Scholar 

  55. Lai WT, Lee CS, Sheu SH, et al.: Electrophysiological manifestations of the excitable gap of slow-fast AV nodal reentrant tachycardia demonstrated by single extrastimulation. Circulation 92:66–76, 1995.

    PubMed  CAS  Google Scholar 

  56. Waldo AL, MacLean WA, Karp RB, et al.: Entrainment and interruption of atrial flutter with atrial pacing: studies in man following open heart surgery. Circulation 56:737–745, 1977.

    PubMed  CAS  Google Scholar 

  57. Hoffman BF, Cranefield PF: Electrophysiology of the Heart. 1st ed. New York: McGraw-Hill, 1960.

    Google Scholar 

  58. Spach MS, Starmer CF: Altering the topology of gap junctions as a major therapeutic target for atrial fibrillation. Cardiovasc Res 30:336–344, 1995.

    Google Scholar 

  59. Alessi R, Nusynowitz M, Abildskov JA, Moe GK: Nonuniform distribution of vagal effects on the atrial refractory period. American Journal of Physiology 194:406–410, 1958.

    PubMed  CAS  Google Scholar 

  60. Coumel P: Autonomic influences in atrial tachyarrhythmias. J Cardiovasc Electrophysiol 7:999–1007, 1998.

    Google Scholar 

  61. Gaspo R, Bosch RF, Bou-Abboud E, Nattel S: Tachycardia-induced changes in Na+ current in a chronic dog model of atrial fibrillation. Circ Res 81:1045–1052, 1997.

    PubMed  CAS  Google Scholar 

  62. Gaspo R, Bosch RF, Talajic M, Nattel S: Functional mechanisms underlying tachycardia-induced sustained atrial fibrillation in a chronic dog model. Circulation 96:4027–4035, 1997.

    PubMed  CAS  Google Scholar 

  63. Tieleman RG, De Langen C, Van Gelder IC, et al.: Verapamil reduces tachycardia-induced electrical remodeling of the atria. Circulation 95:1945–1953, 1997.

    PubMed  CAS  Google Scholar 

  64. Van Wagoner DR, Pond AL, McCarthy PM, et al.: Outward K+ current densities and Kvl.5 expression are reduced in chronic human atrial fibrillation. Circ Res 80:772–781, 1997.

    PubMed  Google Scholar 

  65. Jayachandran V, Zipes DP, Sih HJ, et al.: Atrial ischemia mimics electrophysiologic changes of electrical remodeling which are prevented by blockade of the Na+/H+ exchanger with HDE642 (abstract). Circulation 98(suppl):1–210, 1998.

    Google Scholar 

  66. Jayachandran V, Winkle W, Sih HJ, et al.: Chronic atrial fibrillation from rapid atrial pacing is associated with reduced atrial blood flow: A positron emission tomography study (abstract). Circulation 98(suppl): 1–209, 1998.

    Google Scholar 

  67. Brugada R, Tapscott T, Czernuszewicz GZ, et al.: Identification of a genetic locus for familial atrial fibrillation. New Engl J Med 336:905–911, 1997.

    PubMed  CAS  Google Scholar 

  68. Gould WL: Auricular fibrillation: Report on a familial tendency 1920-1956. Arch Intern Med 100:916–926, 1957.

    CAS  Google Scholar 

  69. Wolff L: Familial atrial fibrillation. New Engl J Med 229:396–400, 1943.

    Google Scholar 

  70. Keating M, Atkinson D, Dunn C, et al.: Linkage of a cardiac arrhythmia, the long QT syndrome, and the Harvey ras-1 gene. Science 252:704–706, 1991.

    PubMed  CAS  Google Scholar 

  71. Sung RJ, Myerburg RJ, Castellanos A: Electrophysiological demonstration of concealed conduction in the human atrium. Circulation 58:940–946, 1978.

    PubMed  CAS  Google Scholar 

  72. Hewlett AW, Wilson FN: Coarse auricular fibrillation in man. Arch Intern Med 15:786–793, 1915.

    Google Scholar 

  73. Evans W, Swann P: Lone auricular fibrillation. Br Heart J 16:189–194, 1954.

    PubMed  CAS  Google Scholar 

  74. Friedlander RD, Levine SA: Auricular fibrillation and flutter without evidence of organic heart disease. New Engl J Med 211:624, 1934.

    Google Scholar 

  75. Phillips E, Levine SA: Auricular fibrillation without other evidence of heart failure. Am J Med 7:478–489, 1949.

    PubMed  CAS  Google Scholar 

  76. Prinzmetel M, Rakita L, Bordaus JL, et al.: The nature of spontaneous auricular fibrillation in man. JAMA 157:1175–1182, 1955.

    Google Scholar 

  77. Brill IC: Auricular fibrillation with congestive failure and no other evidence of organic heart disease. Am Heart J 13:175–182, 1937.

    Google Scholar 

  78. Flaker GC, Fletcher KA, Rothbart RM, et al.: Clinical and echocardiographic features of intermittent atrial fibrillation that predict recurrent atrial fibrillation. Am J Cardiol 76:355–358, 1995.

    PubMed  CAS  Google Scholar 

  79. Coumel P, Attuel P, Lavallee J, et al.: The atrial arrhythmia syndrome of vagal origin. Arch Mal Coeur Vaiss 71:645–656, 1978.

    PubMed  CAS  Google Scholar 

  80. Coumel P. Neural aspects of paroxysmal atrial fibrillation. In: Falk RH, Podrid PJ, eds. Atrial Fibrillation: Mechanisms and Management. New York, NY: Raven Press, 109–125: 1992.

    Google Scholar 

  81. Waxman MB, Cameroon D, Wald RW. Role of the autonomic nervous system in atriat arrhythmias. In: DiMarco JP, Prystowsky EN, eds. Atrial Arrhythmias: State of the Art. Armonk, NY: Futura Publishing Co.: 1995.

    Google Scholar 

  82. Botteron GW, Smith JM: Quantitative assessment of the spatial organization of atrial fibrillation in the intact human heart. Circulation 93:513–518, 1996.

    PubMed  CAS  Google Scholar 

  83. Capucci A, Biffi M, Boriani G, et al.: Dynamic electrophysiological hehavior of human atria during paroxysmal atrial fibrillation. Circulation 92:1193–1202, 1995.

    PubMed  CAS  Google Scholar 

  84. Huagui L, Hare J, Mughal K, et al.: Distribution of atrial electrogram types during atrial fibrillation: Effect of rapid atrial pacing and intercaval junction ablation. J Am Coll Cardiol 27:1713–1721, 1996.

    Google Scholar 

  85. Konings KT, Kirchhof CJ, Smeets JR, et al.: High-density mapping of electrically induced atrial fibrillation in humans. Circulation 89:1665–1680, 1994.

    PubMed  CAS  Google Scholar 

  86. Kumagai K, Khrestian C, Waldo AL: Simultaneous multisite mapping studies during induced atrial fibrillation in the sterile pericarditis model. Insights into the mechanism of its maintenance. Circulation 95:511–521, 1997.

    PubMed  CAS  Google Scholar 

  87. Wells JL, Jr., Karp RB, Kouchoukos NT, et al.: Characterization of atrial fibrillation in man: studies following open heart surgery. Pacing Clin Electrophysiol 1:426–438, 1978.

    PubMed  Google Scholar 

  88. Grimm RA, Stewart WJ, Black IW, et al.: Should all patients undergo transesophageal echocardiography before electrical conversion of atrial fibrillation. J Am Coll Cardiol 23:533–541, 1994.

    PubMed  CAS  Google Scholar 

  89. Manning WJ, Silverman DI, et al.: Temporal dependence of the return of atrial mechanical function on the mode of cardioversion of atrial fibrillation to sinus rhythm. Am J Cardiol 75:624–626, 1995.

    PubMed  CAS  Google Scholar 

  90. Manning WJ, Silverman DI, Katz SE, et al.: Impaired left atrial mechanical function after cardioversion: relation to the duration of atrial fibrillation. J Am Coll Cardiol 23:1535–1540, 1994.

    PubMed  CAS  Google Scholar 

  91. Klein AL, Grimm RA, Black IW, et al.: Cardioversion guided by transesophageal echocardiography: the ACUTE pilot study; a randomized controlled trial. Ann Intern Med 126:200–209, 1997.

    PubMed  CAS  Google Scholar 

  92. Daniel WG, Erbel R, Kasper W, et al.: Safety of transesophageal echocardiography. A multicenter survey of 10,419 examinations. Circulation 83:817–821, 1991.

    PubMed  CAS  Google Scholar 

  93. Ayers GM, Alferness CA, Ilina M, et al.: Ventricular proarrhythmic effects of ventricular cycle length and shock strength in a sheep model of transvenous atrial defibrillation. Circulation 89:413–422, 1994.

    PubMed  CAS  Google Scholar 

  94. Hou ZY, Chang MS, Chen CY, et al.: Acute treatment of recent-onset atrial fibrillation and flutter with a tailored dosing regimen of intravenous amiodarone. EurHeart J 16:521–528, 1995.

    CAS  Google Scholar 

  95. Santini M, Pandozi C, Gentilucci G, et al.: Intra-atrial defibrillation of human atrial fibrillation. J Cardiovasc Electrophysiol 9(suppl):S170–S176, 1998.

    PubMed  CAS  Google Scholar 

  96. Schmitt C, Alt E, Plewan A, et al.: Low-energy intracardiac cardioversion after failed conventional external cardioversion of atrial fibrillation. J Am Coll Cardiol 28:994–999, 1996.

    PubMed  CAS  Google Scholar 

  97. Capucci A, Boriani G, Botto GL, et al.: Conversion of recent-onset atrial fibrillation by a single oral loading dose of propafenone or flecainide. Am J Cardiol 74:503–505, 1994.

    PubMed  CAS  Google Scholar 

  98. Boriani G, Biffi M, Capucci A, et al.: Oral propafenone to convert recent-onset atrial fibrillation in patients with and without underlying heart disease. Ann Intern Med 126:621–625, 1997.

    PubMed  CAS  Google Scholar 

  99. Hondeghem LM, Snyders DJ: Class III antiarrhythmic agents have a lot of potential buta long way to go. Reduced effectiveness and dangers of reverse use dependence. Circulation 81:696–790, 1990.

    Google Scholar 

  100. Kirchhof PF, Fabritz L, Franz MR: Postrepolarization refractoriness versus conduction slowing caused by class I antiarrhythmic drugs. Circulation 97:2567–2574, 1998.

    PubMed  CAS  Google Scholar 

  101. Noma A: ATP-regulated K+ channels in cardiac muscle. Nature 305:147–148, 1983.

    PubMed  CAS  Google Scholar 

  102. Sakmann B, Noma A, Trautwein W: Acetylcholine activation of single muscarinic K+ channels in isolated pacemaker cells of the mammalian, heart. Nature 303:250–253, 1983.

    PubMed  CAS  Google Scholar 

  103. Sung RJ, Tan HL, Karagounis L, et al.: Intravenous sotalol for the termination of supraventricular tachycardia and atrial fibrillation and flutter: a multicenter, randomized, double-blind, placebo-controlled study. Sotalol Multicenter Study Group. Am Heart J 129:739–748, 1995.

    PubMed  CAS  Google Scholar 

  104. Yang T, Snyders DJ, Roden DM: Ibutilide, a methanesulfonamilide antiarrhythmic, is a potent blocker of the rapidly-activating delayed rectifier K+ current (Ikr) in AT-1 cells: concentration, time-, voltage-, and use dependent effects. Circulation 91:1799–1806, 1995.

    PubMed  CAS  Google Scholar 

  105. Lee KS: Ibutilide, a new compound with potent class III antiarrhythmic activity, activates a slow inward Na current in guinea pig ventricular cells. J Pharmacol Exp Ther 262:99–108, 1992.

    PubMed  CAS  Google Scholar 

  106. Ellenbogen KA, Stambler BS, Wood MA, et al.: Efficacy of intravenous ibutilide for rapid termination of atrial fibrillation and atrial flutter: a dose-response study. J Am Coll Cardiol 28:130–136, 1996.

    PubMed  CAS  Google Scholar 

  107. Anderson JL: Long-term safety and efficacy of flecainide in the treatment of supraventricular tachyarrhythmias: the United States experience. American Journal of Cardiology 70:11A–18A, 1992.

    PubMed  CAS  Google Scholar 

  108. Aliot E, Denjoy I, et al.: Comparison of the safety and efficacy of flecainide versus propafenone in hospital out-patients with symptomatic atrial fibrillation/flutter. American Journal of Cardiology 77:66A–71A, 1996.

    PubMed  CAS  Google Scholar 

  109. Chun SH, Sager PT, et al.: Long-term efficacy of amiodarone for the maintenance of normal sinus rhythm in patients with refractory atrial fibrillation or flutter. Am J Cardiol 76:47–50, 1995.

    PubMed  CAS  Google Scholar 

  110. Szyska A, Paluszkiewicz P, Baszynska H: Prophylactic treatment after electroconversion of atrial fibrillation in patients after cardiac surgery — a controlled two year follow-up study (Abstract). J Am Coll Cardiol 21:A–201, 1993.

    Google Scholar 

  111. Crijns HJ, Van Gelder IC, Van Gilst WH, et al.: Serial antiarrhythmic drug treatment to maintain sinus rhythm after electrical cardioversion for chronic atrial fibrillation or atrial flutter. Am J Cardiol 68:335–341, 1991.

    PubMed  CAS  Google Scholar 

  112. Gold RL, Haffajee CI, Charos G, et al.: Amiodarone for refractory atrial fibrillation. Am J Cardiol 57:124–127, 1986.

    PubMed  CAS  Google Scholar 

  113. Juul-Moller S, Edvardsson AN, Rehnqvist-Ahlberg N: Sotalol versus quinidine for the maintenance of sinus rhythm after direct current cardioversion of atrial fibrillation. Circulation 82:1932–1939, 1990.

    PubMed  CAS  Google Scholar 

  114. Middlekauff HR, Wiener I, Stevenson WG: Low-dose amiodarone for atrial fibrillation. Am J Cardiol 72:75F–81F, 1993.

    PubMed  CAS  Google Scholar 

  115. Zehender M, Hohnloser S, Muller B: Effects of amiodarone versus quinidine and verapamil in patients with chronic atrial fibrillation: results of a comparative study and a 2 year follow-up. J Am Coll Cardiol 19:1054–1059, 1992.

    PubMed  CAS  Google Scholar 

  116. Roy D, Talajic M. The Canadian trial of atrial fibrillation: preliminary results. American College of Cardiology 48th Annual Scientific Sessions. New Orleans, 1999.

    Google Scholar 

  117. Sung RJ: Low-dose amiodarone should not be the first-line treatment for atrial fibrillation. Cardiovasc Drugs Ther 8:773–774, 1994.

    PubMed  CAS  Google Scholar 

  118. Rosenqvist M: Atrial pacing for sick sinus syndrome. Clin Cardiol 13:43–47, 1990.

    PubMed  CAS  Google Scholar 

  119. Rosenqvist M, Brandt J, Schuller H: Long-term pacing in sinus node disease: effects of stimulation mode on cardiovascular morbidity and mortality. Am Heart J 116:16–22, 1988.

    PubMed  CAS  Google Scholar 

  120. Andersen HR, Thuesen L, Bagger JP, et al.: Prospective randomised trial of atrial versus ventricular pacing in sick sinus syndrome. Lancet 344:1523–1528, 1994.

    PubMed  CAS  Google Scholar 

  121. Attuel P, Pellerin D, Mugica J, Coumel P: DDD pacing: an effective treatment modality for recurrent atrial arrhythmias. Pacing Clin Electrophysiol 11:1647–1654, 1988.

    PubMed  CAS  Google Scholar 

  122. Murgatroyd FD, Nitzsche R, Slade AK, et al.: A new pacing algorithm for overdrive suppression of atrial fibrillation. Chorus Multicentre Study Group. Pacing Clin Electrophysiol 17:1966–1973, 1994.

    PubMed  CAS  Google Scholar 

  123. Saksena S, Prakash A, Hill M, et al.: Prevention of recurrent atrial fibrillation with chronic dual site right atrial pacing. J Am Coll Cardiol 28:687–694, 1996.

    PubMed  CAS  Google Scholar 

  124. Saksena S, Delfaut P, Prakash A, et al.: Multisite electrode pacing for prevention of atrial fibrillation. J Cardiovasc Electrophysiol 9(suppl):S155–S162, 1998.

    PubMed  CAS  Google Scholar 

  125. The Cardiac Arrhythmia Suppression Trial (CAST) Investigators: Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. N Engl J Med 321:406–412, 1989.

    Google Scholar 

  126. Pritchett EL, Wilkinson WE: Mortality in patients treated with flecainide and encainide for supraventricular arrhythmias. Am J Cardiol 67:976–980, 1991.

    PubMed  CAS  Google Scholar 

  127. Goldman S, Probst P, Selzer A, Cohn K: Inefficacy of “therapeutic” serum levels of digoxin in controlling the ventricular rate in atrial fibrillation. Am J Cardiol 35:651–655, 1995.

    Google Scholar 

  128. Ellenbogen KA, Dias VC, Plumb VJ, et al.: A placebo-controlled trial of continuous intravenous diltiazem infusion for 24-hour heart rate control during atrial fibrillation and atrial flutter: A multicenter study. J Am Coll Cardiol 18:891–897, 1991.

    PubMed  CAS  Google Scholar 

  129. Heywood JT, Graham B, Marais GE, Jutzy KR: Effects of intravenous diltiazem on rapid atrial fibrillation accompanied by congestive heart failure. Am J Cardiol 67:1150–1152, 1991.

    PubMed  CAS  Google Scholar 

  130. Waxman HL, Myerburg RJ, Appel R, Sung RJ: Verapamil for control of ventricular rate in paroxysmal supraventricular tachycardia and atrial fibrillation or flutter: a double-blind randomized cross-over study. Ann Intern Med 94:1–6, 1981.

    PubMed  CAS  Google Scholar 

  131. Garratt C, Antoniou A, Ward D, Camm AJ: Misuse of verapamil in pre-excited atrial fibrillation. Lancet 1:367–369, 1989.

    PubMed  CAS  Google Scholar 

  132. McGovern B, Garan H, Ruskin JN: Precipitation of cardiac arrest by verapamil in patients with Wolff-Parkinson-White syndrome. Ann Intern Med 104:791–794, 1986.

    PubMed  CAS  Google Scholar 

  133. Byrd RC, Sung RJ, Marks J, Parmley WW: Safety and efficacy of esmolol (ASL-8052: an ultrashort-acting beta-adrenergic blocking agent) for control of ventricular rate in supraventricular tachycardias. J Am Coll Cardiol 3:394–399, 1984.

    PubMed  CAS  Google Scholar 

  134. Feld GK, Chen PS, Nicod P, et al.: Possible atrial proarrhythmic effects of class 1C antiarrhythmic drugs. Am J Cardiol 66:378–383, 1990.

    PubMed  CAS  Google Scholar 

  135. Falk RH: Proarrhythmia in patients treated for atrial fibrillation or flutter. Ann Intern Med 117:141–150, 1992.

    PubMed  CAS  Google Scholar 

  136. Murdock CJ, Kyles A, Yeung-Lai-Wah JA, et al.: Atrial flutter in patients treated for atrial fibrillation with propafenone. Am J Cardiol 66:755–757, 1990.

    PubMed  CAS  Google Scholar 

  137. Crijns HJ, van Gelder IC, Lie KI: Supraventricular tachycardia mimicking ventricular tachycardia during flecainide treatment. Am J Cardiol 62:1303–1306, 1988.

    PubMed  CAS  Google Scholar 

  138. Minardo JD, Heger JJ, Miles WM, et al.: Clinical characteristics of patients with ventricular fibrillation during antiarrhythmic drug therapy. N Engl J Med 319:257–262, 1988.

    PubMed  CAS  Google Scholar 

  139. Ruskin JN, McGovern B, Garan H, et al.: Antiarrhythmic drugs: a possible cause of out-of-hospital cardiac arrest. N Engl J Med 309:1302–1306, 1983.

    PubMed  CAS  Google Scholar 

  140. Stanton MS, Prystowsky EN, et al.: Arrhythmogenic effects of antiarrhythmic drugs: a study of 506 patients treated for ventricular tachycardia or fibrillation. J Am Coll Cardiol 14:209–215; 1989.

    PubMed  CAS  Google Scholar 

  141. Koller BS, Karasik PE, Solomon AJ, Franz MR: Relation between repolarization and refractoriness during programmed electrical stimulation in the human right ventricle. Implications for ventricular tachycardia induction. Circulation 91:2378–2384, 1995.

    PubMed  CAS  Google Scholar 

  142. Herre JM, Titus C, Oeff M, et al.: Inefficacy and proarrhythmic effects of flecainide and encainide for sustained ventricular tachycardia and ventricular fibrillation. Ann Intern Med 113:671–676, 1990.

    PubMed  CAS  Google Scholar 

  143. Josephson ME: Antiarrhythmic agents and the danger of proarrhythmic events. Ann Intern Med 111:101–103, 1989.

    PubMed  CAS  Google Scholar 

  144. Morganroth J: Risk factors for the development of proarrhythmic events. Am J Cardiol 59:32E–37E, 1987.

    PubMed  CAS  Google Scholar 

  145. Coromilas J, Saltman AE, Waldecker B, et al.: Electrophysiological effects of flecainide on anisotropic conduction and reentry in infarcted canine hearts. Circulation 91:2245–2263, 1995.

    PubMed  CAS  Google Scholar 

  146. Restivo M, Yin H, Caref EB, et al.: Reentrant arrhythmias in the subacute infarction period: The proarrhythmic effect of flecainide acetate on functional reentrant circuits. Circulation 91:1236–1246, 1995.

    PubMed  CAS  Google Scholar 

  147. Wellens HJ, Sie HT, Smeets JLRM, et al.: Surgical treatment of atrial fibrillation. J Cardiovasc Electrophysiol 9(suppl):S151–S154, 1998.

    PubMed  CAS  Google Scholar 

  148. Cox JL, Schuessler RB, Lappas DG: An 8.5 year clinical experience with surgery for atrial fibrillation. Annals of Surgery 224:267–275, 1996.

    PubMed  CAS  Google Scholar 

  149. Kawaguchi AT, Kosakai Y, Sasako Y, et al.: Risks and benefits of combined maze procedure for atrial fibrillation associated with organic heart disease. J Am Coll Cardiol 28:985–990, 1996.

    PubMed  CAS  Google Scholar 

  150. Sandoval N, Velasco VM, Orjuela H, et al.: Concomitant mitral valve surgery or atrial septal defect surgery and the modified Cox-maze procedure. Am J Cardiol 77:591–596, 1996.

    PubMed  CAS  Google Scholar 

  151. Chua YL, Schaff HV, Orszulak TA, et al.: Outcome of mitral valve repair in patients with pre-operative atrial fibrillation: Should the maze procedure be combined with mitral valvuloplasty? J Thorac Cardiovasc Surg 107:408–415, 1994.

    PubMed  CAS  Google Scholar 

  152. Beukema WP, Hauw ST, Misier ARR, et al.: Radiofrequency modified maze in patients undergoing valve surgery (abstract). PACE 21:11–869, 1998.

    Google Scholar 

  153. Caccitolo JA, Jensen DN, Schaff HV, Mehra R: Can linear radiofrequency ablation lesions replace surgical incisions during open-heart atrial maze procedures? (abstract). PACE 21:111–804, 1998.

    Google Scholar 

  154. Melo J, Adragao P, Neves J, et al.: Radiofrequency pulmonary veins isolation during mitral valve surgery to prevent atrial fibrillation: assessment of one year results (abstract). PACE 21:11–88, 1998.

    Google Scholar 

  155. Langberg JJ, Chin M, Schamp DJ, et al.: Ablation of the atrioventricular junction with radiofrequency energy using a new electrode catheter. Am J Cardiol 67:142–147, 1991.

    PubMed  CAS  Google Scholar 

  156. Fitzpatrick AP, Kourouyan HD, Siu A, et al.: Quality of life and outcomes after radiofrequency His-bundle catheter ablation and permanent pacemaker implantation: impact of treatment in paroxysmal and established atrial fibrillation. Am Heart J 131:499–507, 1996.

    PubMed  CAS  Google Scholar 

  157. Feld GK: Radiofrequency catheter ablation versus modification of the AV node for control of rapid ventricular response in atrial fibrillation. J Cardiovasc Electrophysiol 6:217–228, 1995.

    PubMed  CAS  Google Scholar 

  158. Fleck RP, Chen PS, Boyce K, et al.: Radiofrequency modification of atrioventricular conduction by selective ablation of the low posterior septal right atrium in a patient with atrial fibrillation and a rapid ventricular response. Pacing Clin Electrophysiol 16:377–381, 1993.

    PubMed  CAS  Google Scholar 

  159. Feld GK, Fleck RP, Fujimura O, et al.: Control of rapid ventricular response by radiofrequency catheter modification of the atrioventricular node in patients with medically refractory atrial fibrillation. Circulation 90:2299–2307, 1994.

    PubMed  CAS  Google Scholar 

  160. Williamson BD, Man KC, Daoud E, et al.: Radiofrequency catheter modification of atrioventricular conduction to control the ventricular rate during atrial fibrillation. N Engl J Med 331:910–917, 1994.

    PubMed  CAS  Google Scholar 

  161. Morady F, Hasse C, Strickberger SA, et al.: Long-term follow-up after radiofrequency modification of the atrioventricular node in patients with atrial fibrillation. J Am Coll Cardiol 29:113–121, 1997.

    PubMed  CAS  Google Scholar 

  162. Duckeck W, Engelstein ED, et al.: Radiofrequency current therapy in atrial tachyarrhythmias: modulation versus ablation of atrioventricular nodal conduction. Pacing Clin Electrophysiol 16:629–636, 1993.

    PubMed  CAS  Google Scholar 

  163. Swartz JF, Pellersels G, Silvers J, et al.: A catheter-based curative approach to atrial fibrillation in humans (abstract). Circulation Suppl:1–335, 1994.

    Google Scholar 

  164. Gaita F, Riccardi R, et al.: Atrial mapping and radiofrequency catheter ablation in patients with idiopathic atrial fibrillation. Circulation 97:2136–2145, 1998.

    PubMed  CAS  Google Scholar 

  165. Haissaguerre M, Gencel L, Fischer B, et al.: Successful catheter ablation of atrial fibrillation. J Cardiovasc Electrophysiol 5:1045–1052, 1994.

    PubMed  CAS  Google Scholar 

  166. Haissaguerre M, Shah DC, Jais P, Clementy J: Role of catheter ablation for atrial fibrillation. Curr Opin Cardiol 12:18–23, 1997.

    PubMed  CAS  Google Scholar 

  167. Haissaguerre M, Jais P, Shah DC, et al.: Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N Engl J Med 339:659–666, 1998.

    PubMed  CAS  Google Scholar 

  168. Young, C, Lauer, MR, et al.: unpublished.

    Google Scholar 

  169. Timmermans C, S. L, Tavenier R, and The Worldwide Metrix Investigators: Ambulatory use of the Metrix automatic implantable atrial defibrillator to treat episodes of atrial fibrillation. PACE 21:811, 1998.

    Google Scholar 

  170. Ayers GM, Griffin JC: The future role of defibrillators in the management of atrial fibrillation. Curr Opin Cardiol 12:12–17, 1997.

    PubMed  CAS  Google Scholar 

  171. Barold HS, Wharton JM: Ventricular fibrillation resulting from synchronized internal atrial defibrillation in a patient with ventricular preexcitation. J Cardiovasc Electrophysiol 8:436–440, 1997.

    PubMed  CAS  Google Scholar 

  172. Nathan H, Eliakim M: The junction between the left atrium and the pulmonary veins. An anatomic study of human hearts. Circulation 34:412–422, 1966.

    PubMed  CAS  Google Scholar 

  173. Natale A, Pisano E, Santarelli P, et al.: First experience with a novel through-the-balloon ultrasound ablation catheter for pulmonary vein isolation in patients with atrial fibrillation. Pacing Clin Electrophysiol 23(Pt II):587, 2000.

    Google Scholar 

  174. Haissaguerre M, Shah D, Jais P, et al.: Circular multipolar pulmonary vein catheter for mapping guided minimal ablation of atrial fibrillation. Pacing Clin Electrophysiol 23(Pt II):574, 2000.

    Google Scholar 

  175. Roman-Gonzalez J, Asirvatham S, Johnson SB, et al.: Circumferential lesion creation in the pulmonary veins with a novel tandem balloon ablation catheter in dogs: 6-month follow up. Pacing Clin Electrophysiol 23(Pt II):567, 2000.

    Google Scholar 

  176. Fried NM, Lardo AC, Berger RD, et al.: Circumferential lesions in pulmonary veins using an Nd:YAG laser and fiberoptic balloon catheter. Pacing Clin Electrophysiol 23(Pt II):567, 2000.

    Google Scholar 

  177. Matsudaira K, Nakagawa H, Yamanashi WS, et al.: Effect of blood flow lesion size during cryo-catheter ablation. Pacing Clin Electrophysiol 23(Pt II):741, 2000.

    Google Scholar 

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Sung, R.J., Lauer, M.R. (2000). Atrial Fibrillation. In: Fundamental Approaches to the Management of Cardiac Arrhythmias. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4371-4_14

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