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Transposable Elements and Genome Evolution pp 239–248Cite as

Sectorial mutagenesis by transposable elements

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Part of the book series: Georgia Genetics Review 1 ((GEGR,volume 1))

Abstract

Transposable elements (TEs) generate insertions and cause other mutations in the genomic DNA. It is proposed that during co-evolution between TEs and eukaryotic genomes, an optimal path of the insertion mutagenesis is determined by the surviving TEs. These TEs can become semi-permanently established, chromatin-regulated ‘source’ or ‘mutator genes’, responsible for targeting insertion mutations to specific chromosomal regions. Such mutations can manifest themselves in non-random distribution patterns of interspersed repeats in eukaryotic chromosomes. In this paper we discuss specific models, examples and implications of optimized mutagenesis in eukaryotes.

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  1. Genetic Information Research Institute, 1170 Morse Avenue, Sunnyvale, CA, 94089-1605, USA

    Jerzy Jurka & Vladimir V. Kapitonov

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  1. Jerzy Jurka
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  2. Vladimir V. Kapitonov
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John F. McDonald

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Jurka, J., Kapitonov, V.V. (2000). Sectorial mutagenesis by transposable elements. In: McDonald, J.F. (eds) Transposable Elements and Genome Evolution. Georgia Genetics Review 1, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4156-7_24

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  • DOI: https://doi.org/10.1007/978-94-011-4156-7_24

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