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Cancer of the Anus and the Anal Canal

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Selected Topics in Clinical Oncology

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Abstract

The anal region is divided into an anal canal and a perianal (skin) region or anal margin. The separation is clinically important, as will be discussed further. The boundary however is a matter of extensive discussion in the literature, adding to some confusion in the reporting of the results of treatment.

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References

  • Aliai A., Kurtz J.M., Piparci G., Marti M.C., Miralbell R., Popowski Y., Egeli R., Chemoradiotherapy versus radiotherapy alone for anal cancer: a retrospective comparison, Int.J.Radiat.Oncol. Biol. Phys. 27:59–66 (1993).

    Article  Google Scholar 

  • Aliai A.S., Mermillod B., Roth A.D., Marti M.C., Kurtz J.M., The impact of treatment factors on local control in T2-T3 anal carcinomas treated by radiotherapy with or without chemotherapy. Cancer 78: 2329–2335 (1997).

    Google Scholar 

  • Aliai A.S., Mermillod B., Roth A.D., Marti M.C., Kurtz J.M., Impact of clinical and therapeutic factors on major late complications after radiotherapy with or without concomitant chemotherapy for anal carcinoma, Int.J.Radiat.Oncol.Biol.Phys. 39: 1099–1105 (1997).

    Article  Google Scholar 

  • Aliai A.S., Laurencet F.M., Reymond M.A., Kurtz J.M., Marti M. C. Effectiveness of surgical salvage therapy for patients with locally uncontrolled anal carcinoma after sphincter-conserving treatment, Cancer 86: 405–409 (1999).

    Article  Google Scholar 

  • Bartelink H., Roelofsen F., Eschwege F., Rougier P., Boset J.F., Gonzalez-Gonzalez D., Peiffert D., Van Glabbeke M., Pierart M. Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer, J.Clin.Oncol. 15: 2040–2049 (1997).

    PubMed  CAS  Google Scholar 

  • Basser R.L., Smith J.G., Worotniuk V., Guiney M.J., Conservative management of squamous cell carcinoma of the anal canal, Austr. N.Z.J.Surg. 64: 754–758 (1994).

    Article  CAS  Google Scholar 

  • Beahrs O.H., Wilson S.M., Carcinoma of the anus, Ann.Surg. 184: 422–428 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Bedenne L., Janoray I., Arveux P., Horiot J.C., Janoray P., Ledorze C., Altwegg T., Faivre J., Le cancer épidermoïde du canal anal dans le département de la Côte d’Or, Gastroentérol. Clin. Biol. 15: 130–136 (1991).

    Google Scholar 

  • Cho D. Y., Wang Y.C., Chen J.T., Intradural metastasis to the cau-da equina from carcinoma of the anus. Spine 20: 2341–2344 (1995).

    Article  PubMed  CAS  Google Scholar 

  • Constantinou E.C., Daly W.D., Fung C.Y., Willett C.G., Kaufman D.S., De Laney T.F., Time-dose considerations in the treatment of anal cancer, Int.J.Radiat.Oncol.Biol.Phys. 39: 651–657 (1997).

    Article  PubMed  CAS  Google Scholar 

  • Cummings B.J., The place of radiation therapy in the treatment of carcinoma of the anal canal, Canc.Treatm.Rev. 9: 125–147 (1982).

    Article  CAS  Google Scholar 

  • Cummings B.J., Keane T.J., O’Sullivan B., Wong C.S., Catton C.N. Epidermoid anal cancer: treatment by radiation alone or by radiation and 5-FiuoroUracil with and without mitomycin C., Int.J.Radiat. Oncol.Biol.Phys. 21: 1115–1125 (1991).

    Article  PubMed  CAS  Google Scholar 

  • Cummings B.J., Anal Canal (Radiation Oncology of), Chapter 47 in ‘Principles and Practice of Radiation Oncology, Perezet Brady, editors, second edition, 1992.

    Google Scholar 

  • Cummings B.J., Keane T.J., O’Sullivan B., Wong C.S., Catton C.N. Mitomycin in anal canal carcinoma, Oncology 50(suppl.1): 63–69 (1993).

    Article  PubMed  Google Scholar 

  • Cutuli B., Fenton J., Labib A., Bataini J.P., Mathieu G., Anal margin carcinoma: 21 cases treated at the Institut Curie by exclusive conservative radiotherapy, Radioth.Oncol. 11: 1–6 (1988).

    Article  CAS  Google Scholar 

  • Czech J.M., Lichtor T.R., Carney J.A., Van Heerden J.A., Neoplasms metastatic to the thyroid gland, Surg.Gyn.Obst. 155: 503–505 (1982).

    PubMed  CAS  Google Scholar 

  • Dalby J.E., Pointon R.S., The treatment of anal carcinoma by interstitial irradiation, Am.J.Roentgenol. 85: 515–520 (1961).

    CAS  Google Scholar 

  • Davidson N.G., Yong P.P., Brain metastasis from basaloid carcinoma of the anal canal 8 years after abdominoperineal resection, Eur.J.Surg.Oncol. 17: 227–230 (1991).

    PubMed  CAS  Google Scholar 

  • Doci R., Zucali R., La Monica G., Meroni E., Kenda R., Eboli M., Lozza L., Primary chemoradiation therapy with fluorouracil and cisplatin for cancer of the anus: results in 35 consecutive patients, J.Clin.Oncol. 14: 3121–3125 (1996).

    PubMed  CAS  Google Scholar 

  • Elias D., Lasser P., Comment to Gérard J.P. et al., Le traitement actuel des cancers du canal anal, Ann.Chirurg. 49: 363–372 (1995).

    Google Scholar 

  • Eschwege F., Lasser P., Chavy A., Wibault P., Kae J., Rougier P., Bognel C., Squamous cell carcinoma of the anal canal: treatment by external beam irradiation, Radioth.Oncol. 3: 145–150 (1985).

    Article  CAS  Google Scholar 

  • Fenger C., Anal neoplasia and its precursors: facts and controversies, Sem.Diagn.Pathol. 8: 190–201 (1991).

    CAS  Google Scholar 

  • Flam M., John M., Pajak T.F., Petrelli N., Myerson R., Doggert S., Quivey J, Rotman M., Kerman H., Coia L., Role of mitomycin in combination with FluoroUracil and radiotherapy and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal, J.Clin.Oncol. 14: 2527–2539 (1996).

    PubMed  CAS  Google Scholar 

  • Friberg B., Svensson C., Goldman S., Glimelius, The Swedish national care programme for anal carcinoma: Implementation and overall results, Acta Oncol. 37: 25–32 (1998).

    Article  PubMed  CAS  Google Scholar 

  • Frisch M., Melbye M., Risk factors for anal cancer, J.Irish Coll. Phys.Surg. 24: 198–200 (1995).

    Google Scholar 

  • Frisch M., Glimelius B., Van den Brule A., Wohlfarhrt J., Meijer C.J., Walboomers J.M., Goldman S., Svensson C., Adami H.O., Melbye M., Sexually transmitted infection as a cause of anal cancer, New Engl.J.Med. 337: 1350–1358 (1997).

    Article  PubMed  CAS  Google Scholar 

  • Frisch M., Glimelius B., Van den Brule A.J., Wohlfart J., Meijer C.J., Walboomers J.M., Adami H.O., Benign anal lesions, inflammatory bowel disease and risk for high risk human papillomavirus-positive and-negative anal carcinoma, Brit.J.Cancer 78: 1534–1538 (1998).

    Article  PubMed  CAS  Google Scholar 

  • Frisch M., Glimelius B., Wohlfart J., Adami H.O., Melbye M., Tobacco smoking as a risk factor in anal carcinoma: an antiestrogenic mechanism?, J.Nat.Cane.Inst. 91: 708–715 (1999).

    Article  CAS  Google Scholar 

  • Fuchshuber P.R., Rodriguez-Bigas M., Weber T., Petrelli N.J., Anal and perianal epidermoid cancers, J.Am.Coll.Surg. 185: 494–505 (1997).

    PubMed  CAS  Google Scholar 

  • Garofalo M., Martin C.A., Eng T.T., Donnenfeld H., Smith F.B., Masdeu J.C., Neurologic complications of cloacogenic carcinoma, Am.J.Gastroenterol. 85: 1189–1190 (1990).

    PubMed  Google Scholar 

  • Gerald J.P., Ayzac L., Hun D., Romestaing P., Coquard R., Ardiet J.M., Mornex F., Treatment of anal canal carcinoma with high dose radiation therapy and concomitant fluorouracil-cisplatinum. Long term results in 95 patients, Radiother.Oncol 46: 249–256 (1998).

    Article  Google Scholar 

  • Gerard J.P., Mauro F., Thomas L., Castelain B., Mazeron J.J., Ardiet J.M., Peiffert D., Treatment of squamous cell anal carcinoma with pulsed dose rate brachytherapy, Radioth.Oncol. 51: 129–131 (1999).

    Article  CAS  Google Scholar 

  • Gerard J.P., Morignat E., Romestaing P., Mornex F., Ardiet J.M., Ayzac L., Roy P., La radiothérapie du cancer du canal anal, Ann. Chirurg. 52: 17–23 (1998).

    CAS  Google Scholar 

  • Ghavamzadeh M., Widgren S., Les carcinomes du canal anal Schweiz.Med.Woch. 109: 646–652 (1979).

    CAS  Google Scholar 

  • Gordon P.H., Squamous cell carcinoma of the anal canal, Surg. Clin. No Am. 68: 1391–1399 (1988).

    CAS  Google Scholar 

  • Grabenbauer G., Panzer M., Hültenschmidt B., Döker R., Huber K., Kuhne-Velte H.J., Hutter M., Rühl U., Budach V., Wendt T., Sauer R., Prognostische Faktoren nach simultaner Radiochemotherapie des Analkarzinoms in einer multizentrischen Serie von 139 Patienten, Strahlenther.Onkol. 170: 391–399 (1994).

    PubMed  CAS  Google Scholar 

  • Greenall M.J., Quan S.H., Stearns M.W., Urmacher C., De Cosse J.J., Epidermoid cancer of the anal margin, Am.J.Surg. 149: 95–101 (1985).

    Article  PubMed  CAS  Google Scholar 

  • Heselmeyer K., duManoir S., Biegen B., Friberg B., Svensson C., Schröck E., Veldman T., Shah K., Auer G., Ried T., A recurrent pattern of chromosome aberrations and immunophenotypic appearance defines anal squamous cell carcinomas, Brit.J.Cancer 76: 1271–1278 (1997).

    Article  PubMed  CAS  Google Scholar 

  • Indinnimeo M., Reale M.G., Cicchini C., Stazi A., Fiori E., Izzo P., CEA, TPA, Ca19.9, SCC and CYFRA at diagnosis and in the follow-up of anal canal tumors, Int. Surg. 82: 275–279 (1997).

    PubMed  CAS  Google Scholar 

  • Jensen S.L., Hagen K., Harling H., Shokouh-Amiri M.H., Nilsen O. V., Long-term prognosis after radical treatment for squamous-cell carcinoma of the anal canal and anal margin, Dis.Col.Rect. 31:273–278 (1988).

    Article  CAS  Google Scholar 

  • John M.J., Flam M., Lovalvo L., Mowry P.A., Feasibility of non-surgical definitive management of anal canal carcinoma, Int.J.Ra-diat.Oncol.Biol.Phys. 13: 299–303 (1987).

    Article  CAS  Google Scholar 

  • John M., Flam M., Palma N., Ten-year results of chemoradiation for anal cancer: focus on late morbidity, Int. J.Radiat.Oncol. Biol. Phys. 34:65–69 (1996).

    Article  PubMed  CAS  Google Scholar 

  • John M., Pajak T., Flam M., Hoffman J., Markoe A., Wolkow H., Paris K., Dose escalation in chemoradiation for anal cancer, Cancer J.Sci.Am. 2: 205–211 (1996).

    PubMed  CAS  Google Scholar 

  • Krüger H., Dietrich G., Butters M., Rühl U., Walker S., Analdrü-senkarzinom mit osteoblastischer Metastasierung, Dtsch.Med. Wschr. 123: 1065–1068 (1998).

    Article  PubMed  Google Scholar 

  • LaishVaturi A., Gutman H., Cancer of the anus (review), Oncol. Reports 5: 1525–1529 (1998).

    CAS  Google Scholar 

  • Löhnert M., Doniec J.M., Kovacs G., Schröder J., Dohrmann P., New method of radiotherapy for anal cancer with three-dimensional tumor reconstruction based on endoanal ultrasound and ultrasound-guided afterloading therapy, Dis.Colon Rect. 41: 169–176 (1998).

    Article  Google Scholar 

  • Lopez M.J., Myerson R.J., Shapiro S.J., Fleshman J.W., Fry R.D., Halverson J.D., Kogdner I.J., Monafo W.W., Squamous cell carcinoma of the anal canal, Am.J.Surg. 162: 580–584 (1991).

    Article  PubMed  CAS  Google Scholar 

  • Martensori J.A., Lipsitz S.R., Wauger H., Kaplan E.H., Otteman L.A., Schlichter L.M., Mansour E.G., Talamonti M.S., Benson A.B. Initial results of a phase II-trial of high dose radiation therapy, 5-fluorouracii and cispiatin for patients with anal cancer, Int.J.Radiat. Oncol.Biol.Phys. 35: 749–754 (1996).

    Google Scholar 

  • Melbye M., Rabkin C., Frisch M., Biggar R.J., Changing patterns of anal cancer incidence in the United States 1940-1989, Am.J.Epidemiol. 139:772–780 (1994).

    PubMed  CAS  Google Scholar 

  • Mendenhall W.M., Sombeck M.D., Speer T.W., Marsh R.D., Carroll R.R., Copeland E.M., Current management of squamous cell carcinoma of the anal canal, Surg.Oncol. 3: 135–146 (1994).

    Article  PubMed  CAS  Google Scholar 

  • Mendenha W.M., Zlotecki R.A., Vauthey J.N., Copeland E.M., Squamous cell carcinoma of the anal margin treated with radiotherapy, Surg.Oncol. 5: 29–35 (1996).

    Article  Google Scholar 

  • Miller E.J., Quan S.H., Thaler H.T., Treatment of squamous cell carcinoma of the anal canal, Cancer 67: 2038–2041 (1991).

    Article  PubMed  CAS  Google Scholar 

  • Mitchell E.P., Carcinoma of the anal region, Sem.Oncol. 15: 146–153 (1988).

    CAS  Google Scholar 

  • Myerson R.J., Shapiro S.J., Lacey D., Lopez M., Birnbaum E., Fleshman J., Fry R., Kodner I., Carcinoma of the anal canal, Am.J. Clin.Oncol. 18:32–39 (1995).

    Article  PubMed  CAS  Google Scholar 

  • Myerson R.J., Kamell L.H., Menck H.R., The National Cancer Data Base Report on carcinoma of the anus, Cancer 97: 805–815 (1997).

    Article  Google Scholar 

  • Mullerid M., Salmon R.J., Girodet J., Zafrani B., Dutnllaux B., Recurrent deletions of chromosome 11q and 3p in anal canal carcinoma, Int.J.Cancer 39: 595–598 (1987).

    Article  Google Scholar 

  • NgYingKin N. Y., Pigneux J., Auvray H., Brunet R., Thomas L., Denepoux R., Our experience of conservative treatment of anal canal carcinoma combining external irradiation and interstitial implant, Int.J.Radiat.Oncol.Biol.Phys. 14: 253–259 (1988).

    Article  CAS  Google Scholar 

  • Nigro N.D., An evaluation of combined therapy for squamous cell cancer of the anal canal, Dis.Col.Rect. 27: 763–766 (1984).

    Article  CAS  Google Scholar 

  • Nigro N.D., Multidisciplinary management of cancer of the anus. World J.Surg. 11: 446–451 (1987).

    Article  PubMed  CAS  Google Scholar 

  • Palevsky J.M., Holly E.A., Ralston M.L., Arthur S.P., Jay N., Berry J.M., DaCosta MM, Botts R., Darragh T.M., Anal squamous intra-epithelial lesions in HIV-positive and HIV-negative homosexual and bisexual men, J.Acq.Imm.Def.Syndr.Hum.Retrovir. 17: 320–326 (1998).

    Article  Google Scholar 

  • Panzer M., Sutter T., Wendt T., Jauch K.W., Radiochemotherapie mit und ohne Radikaloperation bei Analkarzinom, Tumordiagn. u.Ther. 14: 157–174 (1993).

    Google Scholar 

  • Papillon J., Chassrd J.L., Respective roles of radiotherapy and surgery in the management of the epidermoid carcinoma of the anal margin, Dis.Col.Rect. 35: 422–429 (1992).

    Article  CAS  Google Scholar 

  • Paradis P., Douglass H.O., Holyoke E.D., The clinical importance of a staging system for carcinoma of the anus, Surg.Gyn.Obst. 141: 411–416 (1975).

    PubMed  CAS  Google Scholar 

  • Peddada A.V., Smith D.E., Rao A.R., Frost D.B., Kagan A.R., Chemotherapy and low-dose radiotherapy in the treatment of HIV-in-fected patients with carcinoma of the anal canal, Int.J.Radiat.On-col. Biol.Phys. 37: 1101–1105 (1997).

    Article  CAS  Google Scholar 

  • Peiffert D., Bey P., Pernot M., Hoffstetter S., Marchal C., Beckendorf V., Guillemin F., Conservative treatment by irradiation of epidermoid carcinomas of the anal margin, Int.J.Radiat.Oncol. Biol.Phys. 39:57–66 (1997).

    Article  PubMed  CAS  Google Scholar 

  • PinnaPintor M., Northover J.M., Nicholls R.J., Squamous cell carcinoma of the anus at one hospital from 1948 to 1984, Brit.J.Surg. 76:806–810 (1989).

    Article  Google Scholar 

  • Poletti P.A., Halfon A., Marti M.C., Papillomavirus and anal carcinoma (in female patients), Int.J.Colorect.Dis. 13: 108–111 (1998).

    Article  CAS  Google Scholar 

  • Rich T.A., Ajani J.A., Morrison W.H., Ota D., Levin B., Chemoradiation therapy for anal cancer: radiation plus continuous infusion of 5-fluorouracil with or without cispiatin, Radiother.Oncol. 27:209–215 (1993).

    Article  PubMed  CAS  Google Scholar 

  • Salmon R.J., Fenton J., Asselain B., Mathieu G., Girodet J., Durand J.C., Decroix Y., Pilleron J.P., Rousseau J., Treatment of epidermoid anal canal cancer, Am.J.Surg. 147: 43–48 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Sandhu A.P., Symonds R.P., Robertson A.G., Reed N.S., MacNee S.G., Paul J., Interstitial iridium-192 implantation combined with external radiotherapy in anal cancer: ten years experience, Int. J.Radiat.Oncol.Biol.Phys. 40: 575–581 (1988).

    Article  Google Scholar 

  • Scherrer A., Reboul F., Martin D., Dupuy J.C., Menu Y., CT of malignant anal canal tumors, Radiographics 10: 433–453 (1990).

    PubMed  CAS  Google Scholar 

  • Schlienger M., Krzisch C., Pene F., Marin J.L., Gindrey-Vie B., Mauban S., Barthelemy N., Habrand J.L., Socie G., Epidermoid carcinoma of the anal canal treatment results and prognostic variables in a series of 242 cases, Int.J.Radiat.Oncol.Biol.Phys. 17: 1141–1148 (1989).

    Article  PubMed  CAS  Google Scholar 

  • Schneider I.H., Grabenbauer G.G., Reck T., Köckerling F., Sauer R., Gall F.P., Combined radiation and chemotherapy for epidermoid carcinoma of the anal canal, Int.J.Colorect.Dis. 7: 192–196 (1992).

    Article  CAS  Google Scholar 

  • Shepherd N.A., Scholefield J.H., Love S.B., England J., Northover J.M., Prognostic factors in anal squamous carcinoma, Histopathology 16: 545–555 (1990).

    Article  PubMed  CAS  Google Scholar 

  • Smith D.E., Shah K., Rao A.R., Frost D.B., Latino F., Anderson P.J., Peddada A.V., Kagan A.R., Cancer of the anal canal: treatment with chemotherapy and low-dose radiation therapy, Radiology 191: 569–572 (1994).

    PubMed  CAS  Google Scholar 

  • Svensson C., Goldman S., Friberg B., Radiation treatment of epidermoid cancer of the anus, Int. J.Radiat.Oncol.Biol.Phys. 27: 67–73 (1993).

    Article  PubMed  CAS  Google Scholar 

  • Svensson C., Goldman S., Friberg B., Glimelius B., Induction chemotherapy and radiotherapy in loco-regionally advanced epidermoid carcinoma of the anal canal, Int. J.Radiat.Oncol.Biol.Phys. 41: 863–867 (1998).

    Article  PubMed  CAS  Google Scholar 

  • Tanum G., Tveit K., Karlsen K.O., Diagnosis of anal carcinoma: doctor’s finger still the best?, Oncology 48: 383–386 (1991).

    Article  PubMed  CAS  Google Scholar 

  • Tanum G.. Tveit K., Karlsen K.O., Hauer-Jensen M., Chemotherapy and radiation therapy for anal carcinoma, Cancer 67: 2462–2466 (1991).

    Article  PubMed  CAS  Google Scholar 

  • Tilston P., Anal human papillomavirus and anal cancer, J.Clin.Pathol. 50:625–634 (1997).

    Article  PubMed  CAS  Google Scholar 

  • Touboul E., Schlienger M., Buffat L., Ozsahin M., Belkacemi Y., Pene F., Balosso J., Lefkopoulos D., Conservative versus nonconservative treatment of epidermoid carcinoma of the anal canal for tumors longer than or equal to 5 centimeters, Cancer 75: 786–793 (1995).

    Article  PubMed  CAS  Google Scholar 

  • Touboul E., Schlienger M., Buffat L., Lefkopoulos D., Yao X.G., Parc R., Tiret E., GFallot D., Malafosse M., Laugier A., Epidermoid carcinoma of the anal margin: 17 cases treated with curative-intent radiation therapy, Radither.Oncol. 34: 195–202 (1995).

    Article  CAS  Google Scholar 

  • UKCCCR Anal cancer trial Working Party (Northover J.M.), Epidermoid anal cancer: results from the UKCCCR randomized trial of radiotherapy alone versus radiotherapy, 5-FluoroUracil and mitomycin, Lancet 348: 1049–1054 (1996).

    Article  Google Scholar 

  • Van Damme J.P., Bonte J.P., Vascular anatomy in abdominal surgery, Geor Thieme Verlag, Stuttgart 1990.

    Google Scholar 

  • Wade D.S., Herrera L., Castillo N.B., Petrelli N.J., Metastases to the lymph nodes in epidermoid carcinoma of the anal canal studied by a cleanng technique, Surg.Gyn.Obst. 169: 238–242 (1989).

    PubMed  CAS  Google Scholar 

  • Wagner J.P., Mahe M.A., Romestaing P., Rocher F.P., Beiger C., Trillet-Lenoir V., Gerard J.P., Radiation therapy in the conservative treatment of carcinoma of the anal canal, Int.J.Radiat.On-col.Biol.Phys. 29: 17–23 (1994).

    Article  CAS  Google Scholar 

  • Williams G.R., Talbot I.C., Anal carcinoma: a histological review, Histopathology 25: 507–516 (1994).

    Article  PubMed  CAS  Google Scholar 

  • Witzigmann H., Sagasser J., Meyer F.M., Witte J., Therapie des Analcarcinoms, Chirurg 65: 344–351 (1994).

    PubMed  CAS  Google Scholar 

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Debois, J.M. (2000). Cancer of the Anus and the Anal Canal. In: Selected Topics in Clinical Oncology. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4100-0_18

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  • DOI: https://doi.org/10.1007/978-94-011-4100-0_18

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