Abstract
The activity of the autonomic nervous system exerts a pervasive influence on cardiovascular health. For many major forms of cardiovascular disease, evidence has been accrued to implicate neurogenic factors either as acute triggers or as longterm catalysts or both. Among the most prominent conditions with an underlying neural component exacerbating cardiovascular dysfunction are hypertension, heart failure, coronary artery disease, and arrhythmias (1). The underlying mechanisms are multifactorial and complex. There are both direct and intermediary factors responsible for the adverse influence of disturbed autonomic activity on cardiovascular health. These range from perturbations in hemodynamic function, particularly elevated arterial blood pressure, and direct effects of neurotransmitters on the myocardium and vascular endothelium.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Braunwald E, ed. Heart Disease: A Textbook of Cardiovascular Medicine, 5th edition. W.B. Saunders: Philadelphia, 1997.
Lown B, Verrier RL. Neural activity and ventricular fibrillation. N Engl J Med 1976;294:1165–1170.
Verrier RL, Mittleman MA. Life-threatening cardiovascular consequences of anger in patients with coronary heart disease. In: Deedwania PC, Tofler GH, eds. Triggers and Timing of Cardiac Events. Cardiology Clinics 1996;14:289–307.
Verrier RL, Hagestad EL, Lown B. Delayed myocardial ischemia induced by anger. Circulation 1987;75:249–254.
Nearing BD, Huang AH, Verrier RL. Dynamic tracking of cardiac vulnerability by complex demodulation of the T-wave. Science 1991;252:437–440.
Nearing BD, Oesterle SN, Verrier RL. Quantification of ischaemia-induced vulnerability by precordial T-wave alternans analysis in dog and human. Cardiovasc Res 1994;28:1440–1449.
Mittleman MA, Maclure M, Sherwood JB, et al. Triggering of acute myocardial infarction onset by episodes of anger. Circulation 1995;92:1720–1725.
Verrier RL, Nearing BD, MacCallum G, Stone PH. T-wave alternans during ambulatory ischemia in patients with coronary heart disease. Annals of Nominvasive Electrocardiology 1996;1:113–120.
De Ferrari GM, Vanoli E, Schwartz PJ. Cardiac vagal activity, myocardial ischemia, and sudden death. In Zipes DP, Jalife J, eds: Cardiac Electrophysiology: From Cell to Bedside. New York, WB Saunders, 1995, pp. 422–434.
Kleiger RE, Miller JP, Bigger JT Jr, et al. The Multicenter Post-Infarction Research Group. Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol 1987;59:256–262.
La Rovere MT, Bigger JT Jr, Marcus FI, Mortara A, Schwartz PJ. Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators. Lancet 1998;351:478–484.
Pantridge JF. Autonomic disturbance at the onset of acute myocardial infarction. In Schwartz PJ, Brown AM, Malliani A, Zanchetti A, eds. Neural Mechanisms in Cardiac Arrhythmias. New York, Raven Press, 1978.
Verrier RL. Physiology of electrical alternans. Cardiac Electrophysiology Review 1997;3:383–388.
Rosenbaum DS, Jackson LE, Smith JM, et al. Electrical alternans and vulnerability to ventricular arrhythmia. N Engl J Med 1994;330:235–241.
Verrier RL. Central nervous system modulation of cardiac rhythm. In Rosen MR, Palti Y, eds. Lethal Arrhythmias Resulting from Myocardial Ischemia and Infarction. Boston, Kluwer Academic Publishers, 1988.
Verrier RL, Kovach JA. Primary role of beta-adrenergic receptors in arrhythmogenesis during sympathetic nervous system activation. In Podrid PJ, Kowey PR, eds. Cardiac Arrhythmias: Mechanism, Diagnosis and Management. Baltimore, Williams & Wilkins, 1995.
Verrier RL. Behavioral stress, myocardial ischemia, and arrhythmias. In Zipes DP, Jalife J, eds. Cardiac Electrophysiology: From Cell to Bedside. New York, WB Saunders, 1990.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2000 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Verrier, R.L. (2000). Role of the Autonomic Nervous System in Cardiovascular Diseases. In: Osterhues, HH., Hombach, V., Moss, A.J. (eds) Advances in Noninvasive Electrocardiographic Monitoring Techniques. Developments in Cardiovascular Medicine, vol 229. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4090-4_6
Download citation
DOI: https://doi.org/10.1007/978-94-011-4090-4_6
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-5796-7
Online ISBN: 978-94-011-4090-4
eBook Packages: Springer Book Archive