Abstract
The persistent generation and transmission of strains of Mycobacterium tuberculosis resistant to the first-line antituberculosis agents have been documented in a large number of settings [1]. In these regions, effective strategies for both the prevention and the treatment of drug-resistant tuberculosis (TB) are required, and delays in their implementation will likely prove costly. Such a strategy must successfully prevent further transmission of new infections through rendering individual patients first, non-infectious, and eventually, cured. Indeed, MDRTB control can only be achieved when all the sources currently fuelling this quietly advancing epidemic are quelled. A central tenet of modern TB control is that treatment is prevention [2]. As with drug-susceptible TB, effective therapy for infectious cases is the only acceptable strategy to curtail further spread of drug-resistant strains of M. tuberculosis, and the only likely way to defuse what some have termed a “time-bomb” [3,4].
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Farmer, P.E., Shin, S.S., Bayona, J., Kim, J.Y., Furin, J.J., Brenner, J.G. (2000). Making DOTS-Plus work. In: Bastian, I., Portaels, F. (eds) Multidrug-resistant Tuberculosis. Resurgent and Emerging Infectious Diseases, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4084-3_19
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DOI: https://doi.org/10.1007/978-94-011-4084-3_19
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