Skip to main content
SpringerLink
Log in
Book cover

Multidrug-resistant Tuberculosis pp 191–203Cite as

Treatment of multidrug-resistant tuberculosis in developing countries

  • Chapter

Part of the book series: Resurgent and Emerging Infectious Diseases ((REID,volume 1))

Abstract

Health professionals are only beginning to address the problems of treating multidrug-resistant tuberculosis (MDRTB) in developing countries. Experience both in developed and developing countries has confirmed that MDRTB can be prevented by a good National Tuberculosis Programme (NTP) with mass treatment by reliable regimens [1–4]. However, there is almost no experience in developing countries of mass treatment of MDRTB. Indeed there is very limited experience even in developed countries [2,5–7]. The problem has only recently begun to be widely discussed internationally. This chapter is based on some personal participation in these discussions by one of us (JC), and the other (AVD) has provided personal experience and preliminary results from MDRTB treatment programmes in Rwanda and Bangladesh. Any recommendations must therefore be provisional until more experience is gained in this field.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Chaisson RE, Coberly JS, De Cock K. DOTS and drug resistance: a silver lining to a darkening cloud. Int J Tuberc Lung Dis 1999; 3: 1–3.

    PubMed  CAS  Google Scholar 

  2. Frieden TR, Fujiwara PI, Washko RM, Hamburg MA. Tuberculosis in New York City — turning the tide. N Engl J Med 1995; 333: 229–233.

    Article  PubMed  CAS  Google Scholar 

  3. Weiss SE, Slocum PC, Blais FX, King B, Nunn M, Matney GB, Gomez E, Foresman BH. The effect of directly observed therapy on rates of drug resistance and relapse in tuberculosis. N Engl J Med 1994; 330: 1179–1184.

    Article  Google Scholar 

  4. Kenyon TA, Mwasekaga MJ, Huebner R, Rumisha D, Binkin N, Maganu E. Low levels of drug resistance amidst rapidly increasing tuberculosis and human immunodeficiency co-epidemics in Botswana. Int J Tuberc Lung Dis 1999; 3: 4–11.

    PubMed  CAS  Google Scholar 

  5. Goble M, Iseman MD, Madsen LA, Waite D, Ackerson L, Horsburgh CR. Treatment of 171 patients with pulmonary tuberculosis resistant to isoniazid and rifampicin. N Engl J Med 1993; 328: 527–532.

    Article  PubMed  CAS  Google Scholar 

  6. Iseman M D. Treatment of multidrug resistant tuberculosis. N Engl J Med 1993; 329: 781–791.

    Google Scholar 

  7. Iseman MD, Huitt G. Treatment of multidrug-resistant tuberculosis, Chapter 11, 175–190. In: Bastian I, Portaels F (eds.), Multidrug-resistant tuberculosis. Kluwer Academic Publ., The Netherlands 2000.

    Chapter  Google Scholar 

  8. Maher D, Chaulet P, Spinaci S, Harries A. Treatment of tuberculosis. Guidelines for national programmes. Geneva: WHO, 1997.

    Google Scholar 

  9. Pablos-Mendez A, Laszlo A, Bustreo F et al. Anti-tuberculosis drug resistance in the world. The WHO/IUATLD global project on anti-tuberculosis drug resistance surveillance. WHO, Geneva 1997.

    Google Scholar 

  10. Pablos-Mendez A, Lessnau K. Clinical mismanagement and other factors producing antituberculosis drug resistance, Chapter 5, 59–76. In: Bastian I, Portaels F (eds.), Multidrugresistant tuberculosis. Kluwer Academic Publ, The Netherlands 2000.

    Chapter  Google Scholar 

  11. Crofton J. Multidrug resistance: Danger for the Third World, Chapter 11, 231–233. In: Porter JDH, McAdam KPWJ (eds.), Tuberculosis: Back to the future. Wiley, Chichester UK 1994.

    Google Scholar 

  12. Crofton J, Chaulet P, Maher D. Guidelines for the management of drug-resistant tuberculosis. WHO, Geneva 1997.

    Google Scholar 

  13. Upelkar MW, Shepard DS. Treatment of tuberculosis by private practitioners in India. Tubercle 1991; 72: 284–290.

    Article  Google Scholar 

  14. Mudur G. Private doctors in India prescribe wrong tuberculosis drugs. Br Med J 1998; 317: 904.

    Google Scholar 

  15. Van Deun A, Aung KJM, Chowdhury S, Saha S, Pankaj A, Ashraf A, Rigouts L, Fissette K, Portaels F. Drug-susceptibility of Mycobacterium tuberculosis in a rural area of Bangladesh and its relevance to the national treatment regimens. Int J Tuberc Lung Dis 1999; 3: 143–148.

    PubMed  Google Scholar 

  16. Datta M., Radhamani MP, Selvaraj R, Paramasivan CN, Gopalan BN, Sudeendra CR, Prabhakar R. Critical assessment of smear-positive pulmonary tuberculosis patients after chemotherapy under the district tuberculosis programme. Tubercle Lung Dis 1993; 74: 180–186.

    Article  CAS  Google Scholar 

  17. Mitchison DA. How drug resistance emerges as the result of poor compliance during short course chemotherapy for tuberculosis. Int J Tuberc Lung Dis 1998; 2: 10–15.

    PubMed  CAS  Google Scholar 

  18. Espinal M. Epidemiology of multidrug-resistant tuberculosis in resource-poor countries, Chapter 3, 29–44. In: Bastian I, Portaels F (eds.), Multidrug-resistant tuberculosis. Kluwer Academic Publ., The Netherlands 2000.

    Chapter  Google Scholar 

  19. Chaulet P, Zidouni N. Evaluation of applied strategies of tuberculosis control in the developing world, 601–627. In: Reichman LB, Hershfield ES (eds.), Tuberculosis, a comprehensive international approach. Marcel Dekker Inc, New York 1993.

    Google Scholar 

  20. Crofton J. The prevention and management of drug resistant tuberculosis. Bull Int Union Tuberc Lung Dis 1987; 62: 6–11.

    PubMed  CAS  Google Scholar 

  21. Harkin TJ, Harris HW. Treatment of multidrug resistant tuberculosis, Chapter 70, 843–850. In: Rom W N, Stuart G (eds.), Tuberculosis. Little Brown, New York 1996.

    Google Scholar 

  22. Farmer P, Kim JY. Community-based approaches to the control of multidrug resistant tuberculosis: introducing “DOTS-plus”. Br Med J 1998; 317: 671–674.

    Article  CAS  Google Scholar 

  23. Farmer PE, Shin SS, Bayona J, et al. DOTS-plus, Chapter 19, 285–306. In: Bastian I, Portaels F (eds.), Multidrug-resistant tuberculosis. Kluwer Academic Publ., The Netherlands 2000.

    Chapter  Google Scholar 

  24. WHO. Global tuberculosis control: WHO report 1999. WHO, Geneva 1999.

    Google Scholar 

  25. Blower S, Small P, Hopewell P. Control strategies for tuberculosis epidemics: new models for old problems. Science 1996; 273: 497–500.

    Article  PubMed  CAS  Google Scholar 

  26. .Frieden TR. What should be the response to a reported rise in drug-resistant tuberculosis? (Abstract). Global Congress on Lung Health / 29th World Conference of the IUATLD, Bangkok 23-26 November 1998. Int J Tuberc Lung Dis 1998; 2: S180–181.

    Google Scholar 

  27. Coninx R, Pfyffer GE, Mathieu C, Savina D, Debacker M, Jafarov F, Jabrailov I, Ismailov A, Mirzoev F, de Haller R, Portaels F. Drug resistant tuberculosis in prisons in Azerbaijan: case study. Br Med J 1998; 316: 1423–1425.

    Article  CAS  Google Scholar 

  28. Maher D, Grzemska M, Coninx R, Reyes H. Guidelines for the control of tuberculosis in prisons. WHO and International Committee of the Red Cross, Geneva 1998.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Respiratory Diseases and Tuberculosis, University of Edinburgh, Scotland

    Sir John Crofton (Professor Emeritus)

  2. Mycobacteriology Unit, Institute of Tropical Medicine, Antwerp, Belgium

    Armand Van Deun

Authors
  1. Sir John Crofton
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Armand Van Deun
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Mycobacterium Reference Laboratory, Institute of Medical & Veterinary Science, Adelaide, Australia

    Ivan Bastian

  2. Mycobacteriology Unit, Institute of Tropical Medicine, Antwerp, Belgium

    Françoise Portaels

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Crofton, J., Van Deun, A. (2000). Treatment of multidrug-resistant tuberculosis in developing countries. In: Bastian, I., Portaels, F. (eds) Multidrug-resistant Tuberculosis. Resurgent and Emerging Infectious Diseases, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4084-3_12

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-4084-3_12

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5794-3

  • Online ISBN: 978-94-011-4084-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation