Fatty-acid SPECT imaging for assessment of myocardial viability
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Because fatty acids are the preferred source of energy substrate by the contracting myocardium, fatty-acid imaging has been viewed with interest in the last four decades as a potential noninvasive means to explore the myocardial metabolism [1,2]. Over the years, a large number of iodine-labeled fatty acids have been tried either experimentally or clinically (Table 1). Yet, the clinical utilization of fatty-acid imaging in the United States has been hampered by the lack of a commercially available product as well as by uncertainties about the intrinsic mechanisms of uptake, concentration and release of different fatty acids by the myocytes. In Japan, the branched fatty acid iodine-123 methyl-pentadecanoic acid (BMIPP) is commercially available and has been used with some frequency.
KeywordsSingle Photon Emission Compute Tomography Fatty Acid Uptake Pentadecanoic Acid BMIPP Uptake Myocardial Fatty Acid Metabolism
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