Skip to main content
SpringerLink
Log in

Fatty-acid SPECT imaging for assessment of myocardial viability

  • Chapter
Myocardial Viability

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 226))

  • 57 Accesses

Abstract

Because fatty acids are the preferred source of energy substrate by the contracting myocardium, fatty-acid imaging has been viewed with interest in the last four decades as a potential noninvasive means to explore the myocardial metabolism [1,2]. Over the years, a large number of iodine-labeled fatty acids have been tried either experimentally or clinically (Table 1). Yet, the clinical utilization of fatty-acid imaging in the United States has been hampered by the lack of a commercially available product as well as by uncertainties about the intrinsic mechanisms of uptake, concentration and release of different fatty acids by the myocytes. In Japan, the branched fatty acid iodine-123 methyl-pentadecanoic acid (BMIPP) is commercially available and has been used with some frequency.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Evans JR, Gunton RW, Baker RG et al. Use of radioiodinated fatty acid for photoscans of the heart. Circ Res 1965;16:1–10.

    Article  PubMed  CAS  Google Scholar 

  2. Gunton RW, Evans JR, Baker RG, Spears JC, Beanlands DS. Demonstration of myocardial infarction by photoscans of the heart in man. Am J Cardiol 1965;16:482–487.

    Article  PubMed  CAS  Google Scholar 

  3. Visser FC, Westera G, Van Eenige MJ, Van der Wall EE, Den Hollander W, Roos JP. The myocardial elimination rate of radioiodinated heptadecanoic acid. Eur J Nucl Med 1985;10:118–122.

    Article  PubMed  CAS  Google Scholar 

  4. Van der Wall EE, Heidendal GA, den Hollander W, Westera G, Roos JP. I-123 labeled hexadecanoic acid in comparison with thallium-201 for myocardial imaging in coronary heart disease. Eur J Nucl Med 1980:5:401–405.

    Article  PubMed  Google Scholar 

  5. Van der Wall EE, Heidendal GA, den Hollander W, Westera G, Roos JP. Metabolic myocardial imaging with 123-I labeled heptadecanoic acid in patients with angina pectoris. Eur J Nucl Med 1981;6:391–396.

    PubMed  Google Scholar 

  6. Van der Wall EE, Heidendal GA, den Hollander W, Westera G, Roos JP. Myocardial scintigraphy with 123I-labeled heptadecanoic acid in patients with unstable angina pectoris. Postgrad Med J 1983;59 suppl 3:38–40.

    PubMed  Google Scholar 

  7. Otto CA, Brown LE, Wieland DM, Beierwaltes WH. Radioiodinated fatty acids for myocardial imaging: effects of chain length. J Nucl Med 1981;22:613–618.

    PubMed  CAS  Google Scholar 

  8. Machulla HJ, Marsmann M, Dutschka K. 131I-(phenyl)-pentadecanoic acid, a highly promising radioiodinated fatty acid for myocardial studies. I. Development of synthesis and radiophamaceutical quality. Radioaktive Isot Klin Forsch 1980;14:363–367.

    CAS  Google Scholar 

  9. Machulla HJ, Marsmann M, Dutschka K. Radiopharmaceuticals: synthesis of radioiodinated phynyl fatty acics for studying myocardial metabolism. J Radioanal Chem 1980;56:253–258.

    Article  CAS  Google Scholar 

  10. Kulkarni PV, Parkey RW. A new radioiodination method utilizating organothalium intermediate: Radioiodination of phereynypentadecanoic acid (PPA) for potential applications in myocardial imaging. J Nucl Med 1982;23 (6 suppl):p105.

    Google Scholar 

  11. Reske SN, Sauer W, Machulla HJ, Winkler C. 15(p-[123I]iodophenyl) pentadecanoic acid as a tracer of lipid metabolism: comparison with [1-14C] palmitic/acid in murine tissues. J Nucl Med 1984;25:1335–1342.

    PubMed  CAS  Google Scholar 

  12. Reske SN, Sauer W, Machulla HJ, Knust J, Winkler C. Metabolism of 15 (p123I iodophenyl)-pentadecanoic acid in heart muscle and noncardiac tissues. Eur J Nucl Med 1985;10:228–234.

    Article  PubMed  CAS  Google Scholar 

  13. Relias JS, Corbett JR, Kulkarni P et al. Iodine-123 phenylpentadecanoic acid: detection of acute myocardial infarction and injury in dogs using an iodinated fatty acid and single-photon emission tomography. Am J Cardiol 1983;52:1326–1332.

    Article  Google Scholar 

  14. Dudczak R, Schmoliner R, Kletter K, Frischauf H, Angelberger P. Clinical evaluation of 1231-labeled p-phenylpentadecanoic acid (p-IPPA) for myocardial scintigraphy. J Nucl Med Allied Sci 1983;27:267–279.

    PubMed  CAS  Google Scholar 

  15. Wolfe CL, Kennedy PL, Kulkarni P, Jansen DE, Gabliani GI, Corbett JR. Iodine-123 phenylpentadecanoic acid myocardial scintigraphy in patients with left ventricular hypertrophy: alterations in left ventricular distribution and utilization. Am Heart J 1990;119:1338–1347.

    Article  PubMed  CAS  Google Scholar 

  16. Kropp J, Likungu J, Kirchhoff PG et al. Single photon emission tomography imaging of myocardial oxidative metabolism with 15(p-[123]iodophynl) pentadecanoic acid in patients with coronary artery disease and aorto-coronary bypass graft surgery. Eur J Nucl Med 1991;18:467–474.

    Article  PubMed  CAS  Google Scholar 

  17. Kennedy PL, Corbett JR, Kulkarni PV et al. Iodine 123-phenylpentadecanoic acid myocardial scintigraphy: usefulness in the identification of myocardial ischemia. Circulation 1986;74:1007–1015.

    Article  PubMed  CAS  Google Scholar 

  18. Hansen CL, Corbett JR, Pippin JJ et al. Iodine-123 phenylpentadecanoic acid and single-photon emission computed tomography in identifying left ventricular regional metabolic abnormalities in patients with coronary heart disease: comparison with thallium-201 myocardial tomography. J Am Coll Cardiol 1988;12:78–87.

    Article  PubMed  CAS  Google Scholar 

  19. Schad N, Daus HJ, Ciavolella M, Maccio H. Noninvasive functional imaging of regional rate of myocardial fatty acids metabolism. Cardiologia 1987;32:239–247.

    PubMed  CAS  Google Scholar 

  20. Ugolini V, Hansen CL, Kulkarni PV, Jansen DE, Akers MS, Corbett JR. Abnormal myocardial fatty acid metabolism in dilated cardiomyopathic detected by Iodine-123 phenylpentadecanoic acid and tomographic imaging. Am J Cardiol 1988;62:923–928.

    Article  PubMed  CAS  Google Scholar 

  21. Murray G, Schad N, Ladd W et al. Metabolic cardiac imaging in severe coronary disease: assessment of viability with iodine-123I-Iodophenyl-pentadecanoic acid and multicrystal gamma camera, and correlation with biopsy. J Nucl Med 1992;33:1269–1277.

    PubMed  CAS  Google Scholar 

  22. Iskandrian AS, Powers J, Cave V, Wasserleben V, Cassell D, Heo J. Assessment of myocardial viability by dynamic tomographic iodine 123 iodophenylpentadecanoic acid imaging: comparison with rest-redistribution thallium 201 imaging. J Nucl Cardiol 1995;2:101–109.

    PubMed  CAS  Google Scholar 

  23. Verani MS, Taillefer R, Iskandrian AE, Mahmarian JJ, He ZX, for the Multicenter IPPA Viability Trial Investigators. I-123 Iodophenylpentadecanoic Acid (IPPA) single photon emission tomography for the prediction of enhanced left ventricular function after coronary bypass graft surgery. Submitted for publication, 1998.

    Google Scholar 

  24. Knapp FF Jr, Kropp J. Iodine-123-labelled fatty acids for myocardial single-photon emission tomography: current status and future perspectives. Eur J Nucl Med 1995;22:361–381.

    Article  PubMed  CAS  Google Scholar 

  25. Nohara R, Okuda K, Ogino M et al. Evaluation of myocardial viability with iodine-123-BMIPP in a canine model. J Nucl Med 1996;37:1403–1407.

    PubMed  CAS  Google Scholar 

  26. Fujibayashi Y, Yonekura Y, Takemura Y et al. Myocardial accumulation of iodinated beta-methyl-branched fatty acid analogue, iodine-125-15-(p-iodophenyl)-3-(R,S) methylpentadecanoic acid (BMIPP), in relation to ATP concentration. J Nucl Med 1990;31:1818–1822.

    PubMed  CAS  Google Scholar 

  27. Hosokawa R, Nohara R, Fujibayashi Y et al. Myocardial kinetics of iodine-123-BMIPP in canine myocardium after regional ischemia and reperfusion: implications for clinical SPECT. J Nucl Med 1997;38:1857–1863.

    PubMed  CAS  Google Scholar 

  28. Dormehl IC, Hugo N, Rossouw D, White A, Feinendengen LE. Planar myocardial imaging in the baboon model with iodine-123-15-(iodophenyl) pentadecanoic acid (IPPA) and iodine-123-15-(P-Iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP), using time-activity curves for evaluation of metabolism. Nucl Med Biol 1995;22:837–847.

    Article  PubMed  CAS  Google Scholar 

  29. Kurata C, Wakabayashi Y, Shouda S et al. Influence of blood substrate levels on myocardial kinetics of iodine-123-BMIPP. J Nucl Med 1997;38:1079–1084.

    PubMed  CAS  Google Scholar 

  30. Tateno M, Tamaki N, Yukihiro M et al. Assessment of fatty acid uptake in ischemic heart disease without myocardial infarction. J Nucl Med 1996;37:1981–1985.

    PubMed  CAS  Google Scholar 

  31. Fujiwara S, Takeishi Y, Atsumi H, Takahashi K, Tomoike H. Fatty acid metabolic imaging with Iodine-123-BMIPP for the diagnosis of coronary artery disease. J Nucl Med 1997;38:175–180.

    PubMed  CAS  Google Scholar 

  32. Takeishi Y, Fujiwara S, Atsumi H, Takahashi K, Sukekawa H, Tomoike H. Iodine-123-BMIPP imaging in unstable angina: a guide for interventional strategy. J Nucl Med 1997;38:1407–1411.

    PubMed  CAS  Google Scholar 

  33. Taki J, Nakajima K, Matsunari I et al. Assessment of improvement of myocardial fatty acid uptake and function after revascularization using iodine-123-BMIPP. J Nucl Med 1997;38:1503–1510.

    PubMed  CAS  Google Scholar 

  34. Kobayashi H, Kusakabe K, Momose M et al. Evaluation of myocardial perfusion and fatty acid uptake using a single injection of iodine-123-BMIPP in patients with acute coronary syndromes. J Nucl Med 1998;39:1117–1122.

    PubMed  CAS  Google Scholar 

  35. De Geeter F, Franken PR, Knapp FF Jr, Bossuyt A. Relationship between blood flow and fatty acid metabolism in subacute myocardial infarction: a study by means of 99mTc-Sestamibi and 123I-beta-methyl-iodo-phenyl pentadecanoic acid. Eur J Nucl Med 1994;21:283–291.

    Article  PubMed  Google Scholar 

  36. Ito T, Tanouchi J, Kato J et al. Recovery of impaired left ventricular function in patients with acute myocardial infarction is predicted by the discordance in defect size on 123I-BMIPP and 201Tl SPET images. Eur J Nucl Med 1996;23:917–923.

    Article  PubMed  CAS  Google Scholar 

  37. Tamaki N, Tadamura E, Kudoh T et al. Prognostic value of iodine-123 labelled BMIPP fatty acid analogue imaging in patients with myocardial infarction. Eur J Nucl Med 1996;23:272–279.

    Article  PubMed  CAS  Google Scholar 

  38. Taki J, Nakajima K, Matsunari I, bunko H, Takada S, Tonami N. Impairment of regional fatty acid uptake in relation to wall motion and thallium-201 uptake in ischaemic but viable myocardium; assessment with iodine-123-labelled beta-methyl-branched fatty acid. Eur J Nucl Med 1995;22:1385–1392.

    Article  PubMed  CAS  Google Scholar 

  39. Sloof GW, Visser FC, Bax JJ et al. Increased uptake of iodine-123-BMIPP in chronic ischemic heart disease: comparison with fluorine-18-FDG SPECT. J Nucl Med 1998;39:255–260.

    PubMed  CAS  Google Scholar 

  40. Haque T, Furukawa T, Yoshida S et al. Echocardiography and fatty acid single photon emission tomography in predicting reversibility of regional left ventricular dysfunction after coronary angioplasty. Eur Heart J 1998;19:332–341.

    Article  PubMed  CAS  Google Scholar 

  41. Nakata T, Hashimoto A, Kobayashi H et al. Outcome significance of thallium-201 and iodine-123-BMIPP perfusion — metabolism mismatch in preinfarction angina. J Nucl Med 1998;39:1492–1499.

    PubMed  CAS  Google Scholar 

  42. Mori T, Hayakawa M, Hattori K et al. Exercise beta-methyl iodophenyl pentadecanoic acid (BMIPP) and resting thalium delayed single photon emission computed tomography (SPECT) in the assessment of ischemia and viability. Jpn Circ J 1996;60:17–26.

    Article  PubMed  CAS  Google Scholar 

  43. Tadamura E, Kudoh T, Hattori N et al. Impairment of BMIPP uptake precedes abnormalities in oxygen and glucose metabolism in hypertrophic cardiomyopathy. J Nucl Med 1998;39:390–396.

    PubMed  CAS  Google Scholar 

  44. Matsuo S, Nakamura Y, Takahashi M, Mitsunami K, Kinoshita M. Myocardial metabolic abnormalities in hypertrophic cardiomyopathic assessed by iodine-123-labeled beta-methyl-branched fatty acid myocardial scintigraphy and its relation to exercise-induced ischemia. Jpn Circ J 1998;62:167–172.

    Article  PubMed  CAS  Google Scholar 

  45. Shimizu M, Yoshio H, Ino H et al. Myocardial scintigraphic study with 123I 15-(p-iodophenyl)-3(R,S)-methylpentadecanoic acid in patients with hypertrophic cardiomyopathy. Int J Cardiol 1996;54:51–59.

    Article  PubMed  CAS  Google Scholar 

  46. Kudoh T, Tamaki N, Magata Y et al. Metabolism substrate with negative myocardial uptake of iodine-123-BMIPP. J Nucl Med 1997;38:548–553.

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Mario S. Verani
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Nuclear Cardiology, Division Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama, USA

    Ami E. Iskandrian (Director) (Director)

  2. Department of Cardiology, Leiden, University Medical Center, Leiden, The Netherlands

    Ernst E. Van Der Wall

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Verani, M.S. (2000). Fatty-acid SPECT imaging for assessment of myocardial viability. In: Iskandrian, A.E., Van Der Wall, E.E. (eds) Myocardial Viability. Developments in Cardiovascular Medicine, vol 226. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4080-5_6

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-4080-5_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5793-6

  • Online ISBN: 978-94-011-4080-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation