Technetium-99m-labeled perfusion tracers for the detection of myocardial viability

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 226)


Technetium-99m(Tc-99m)-labeled myocardial perfusion tracers offer several advantages over thallium-201 for the diagnosis and evaluation of coronary artery disease. However, because of the results of some early human studies, concerns were advanced about their usefulness and reliability for the detection of viable hibernating myocardium. The majority of the experimental data and the more recent clinical reports have greatly reduced these concerns, so that the use of Tc-99m-labeled myocardial perfusion tracers for the issue of viability detection should be probably considered a reasonable alternative to the other established methods. The largest experience has been collected about Tc-99m-sestamibi and will be thoroughly examined in the following sections. Promising data, which are briefly reported as well, are now becoming available about the other currently used Tc-99m-labeled perfusion tracer, Tc-99m-tetrofosmin.


Myocardial Viability Chronic Coronary Artery Disease Perfusion Tracer Nitrate Administration Viability Detection 
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