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Caspase-10 mutations in the autoimmune lymphoproliferative syndrome type II

  • Chapter
Immunology and Liver

Part of the book series: Falk Symposium ((FASS,volume 114))

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Abstract

Apoptosis plays an essential role in maintaining homeostasis in lymphocytes. Antigen-provoked apoptosis of lymphocytes, or propricidal regulation, can be mediated by Fas (CD95/APO-1), tumour necrosis factor receptor (TNFR) and related molecules1-5. Other death ligands such as TRAIL and its corresponding death receptors DR4 and DR5 are expressed in immune cells, but their physiological functions are not well understood6-11. Recent experiments suggest that the fate of specialized antigen-presenting cells is also regulated during immune responses. Ingulli et al. (1997) have shown that antigen-bearing dendritic cells directly interact with antigen-specific T cells resulting in T cell activation and disappearance of the dendritic cells12. Because dendritic cells are potent stimulators of B cells and T cells, their turnover may be essential for regulating immune responses13. However, currently little is known about how this process is regulated.

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Authors
  1. J. Wang
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  2. M. J. Lenardo
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Editor information

Editors and Affiliations

  1. Abt. Gastroenterologie/Hepatologie Zentrum Innere Medizin, Medizinische Hochscule Hannover, Carl-Neuberg Str. 1, D-30625, Hannover, Germany

    M. P. Manns

  2. Medizinische Klinik II, Klinikum Grosshadern der LMU München, Marchioninistr. 15, D-81377, München, Germany

    G. Paumgartner

  3. Abt. Gastroenterologie Zentrum der Innere Medizin, Klinikum der Johann-Wolfgang-Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, D-60596, Frankfurt, Germany

    U. Leuschner

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© 2000 Springer Science+Business Media Dordrecht

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Wang, J., Lenardo, M.J. (2000). Caspase-10 mutations in the autoimmune lymphoproliferative syndrome type II. In: Manns, M.P., Paumgartner, G., Leuschner, U. (eds) Immunology and Liver. Falk Symposium, vol 114. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4000-3_4

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  • DOI: https://doi.org/10.1007/978-94-011-4000-3_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5768-4

  • Online ISBN: 978-94-011-4000-3

  • eBook Packages: Springer Book Archive

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