Abstract
Autoimmune diseases are mediated by lymphocytes reactive with self-antigens. While autoantibody-producing B cells are an important component of many autoimmune diseases, including autoimmune hepatitis, it is thought that autoreactive T lymphocytes play the key role in the aetiopathogenesis of most if not all autoimmune diseases, be it as helper cells allowing and supporting maturation of autoreactive B cells, or more importantly as critical mediators of autoreactive cell damage directly. Within the T cell compartment the CD4-positive cells seem to play the most important role in autoimmune diseases. While in human autoimmune diseases the evidence for CD4 cells as key mediator is only indirect, various experimental animal models have shown convincingly that CD4 cells induce and transfer the autoimmune disease process.
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Lohse, A.W. (2000). T cell vaccination as potential therapy for autoimmune hepatitis. In: Manns, M.P., Paumgartner, G., Leuschner, U. (eds) Immunology and Liver. Falk Symposium, vol 114. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4000-3_32
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DOI: https://doi.org/10.1007/978-94-011-4000-3_32
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